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Entree, Vegetarian, Kid Friendly, Sponsored |290 calories per serving|25 minute recipe

Grape Grilled Cheese

This content was last updated on June 18, 2021

Research shows that eating a mostly plant-based diet with whole grains, vegetables, fruits and beans plays a big role in preventing cancer and contributing to a healthier life. Plant foods are high in the types of fiber, nutrients and natural compounds that may help to prevent cancer. Colorful grapes—green, red, purple—are a naturally sweet addition to a plant forward diet; they contain resveratrol and a variety of other plant compounds that have been studied for their possible role in reducing cancer risk. Adding grapes, including bright red, candy flavored Gummyberry grapes, to this easy grilled cheese sandwich is a fun, fresh and flavorful way to gets kids and adults excited about eating more plants!

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  • 2 tsp. extra-virgin olive oil
  • 1 small onion, cut into ½-inch dice (about 1 cup)
  • 1 cup red grapes, cut into half or quarters
  • 1/2 cup fresh basil leaves, roughly chopped
  • Pinch of kosher salt
  • Pinch of black pepper
  • Zest of half a lemon, optional
  • 8 thin slices part-skim mozzarella cheese*
  • 8 slices 100% whole-grain bread
  • Nonstick cooking spray
Makes 4 servings (1 sandwich). Per serving: 290 calories, 11 g total fat (4.5 g saturated fat, 0 g trans fat), 20 mg cholesterol, 37 g carbohydrates, 15 g protein, 6 g dietary fiber, 450 mg sodium, 12 g sugar, 0 g added sugar.


  1. Heat oil in large nonstick skillet over medium heat. Add onion and cook, stirring often, until softened, 5 minutes.
  2. Reduce heat to medium low. Add grapes, basil and salt and pepper, to taste. Cook, stirring occasionally, until warmed through, 2 minutes. Add lemon zest, if using. Place grape mixture in bowl. Remove skillet from heat and carefully wipe clean with paper towels.
  3. Top 4 bread slices with 1 slice cheese each. Top evenly with grape mixture, remaining 4 cheese slices and another slice of bread to make a sandwich.
  4. Spray skillet generously with nonstick cooking spray. Heat skillet over medium heat. Add sandwiches to skillet, press down with spatula, and cook until bottoms are golden, about 3 minutes. Adjust heat to medium low if bread browns too quickly. Spray tops of bread with additional cooking spray. Carefully flip each sandwich, and cook until bottoms are golden and cheese is melted, 2 to 3 more minutes.
  5. Slice, and let sandwiches cool down to warm before serving.


Serve with a variety of colorful grapes on the side.

*May use reduced-fat Cheddar cheese (4 oz.) in place of part-skimmed mozzarella

Written for AICR and Divine Flavor by  Liz Weiss, MS, RDN LIZ’S HEALTHY TABLE who is an award-winning author, blogger, podcaster and nutrition expert.

Sponsored By

This recipe contains cancer fighting foods:

This recipe was specially crafted to support cancer prevention and survival. It adheres to AICR's Cancer Prevention Recommendations. Learn more about our recipe guidelines.

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July 7, 2023

I have had osteoarthritis for 27 years and I’m trying to make better choices in my diet. These recipes such as Grilled Cheese Sandwiches (my favorite), Chinese Chicken Salad, etc, can be healthy just by swapping out a few ingredients. They are also easy to prepare, which I appreciate since standing is painful. I will definitely be trying a few of these recipes.

Patricia Coldiron


June 21, 2021

I’ve never cooked grapes before and this was awesome! My husband loved it too! Can’t wait to make again.

Faron Moreno