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Research Projects > 2008 Grantees

Transcriptional Attenuation Induced by Sodium Butyrate and Vitamin D3 in Colon Cancer Cells

Project Description

Vitamin D and sodium butyrate, generated by the fermentation of dietary fiber are both regulators of colon maturation and gene expression. They regulate gene expression through a process called transcriptional attenuation. Since the mechanisms of transcriptional attenuation are largely unknown this study sought to examine and characterize the candidate genes for transcriptional attenuation using a novel, custom built microarray analysis to understand the nature and regulatory mechanisms recruited by two nutritional factors that coordinate colonic cell maturation.

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