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Entree, Seafood |410 calories per serving|40 minute recipe

Sheet-Pan Salmon with Roasted Fall Vegetables

This content was last updated on September 30, 2020

This delicious one-pan meal is a great staple recipe that comes together quickly, and it’s packed with cancer-fighting ingredients. The salmon is rich in heart-healthy omega-3 fatty acids, while also being low in saturated fat. Butternut squash and Brussels sprouts add color and flavor to the meal along with a hearty dose of cancer-protective fiber. Soy sauce, ginger and a touch of maple syrup tie in the flavors for this one-pan meal.

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  • 2 Tbsp. low sodium soy sauce
  • 1 Tbsp. sesame oil
  • 1 Tbsp. maple syrup
  • 1 Tbsp. fresh lime juice
  • 1/4 tsp. red pepper flakes
  • 1 clove garlic, minced plus 3 whole cloves, smashed
  • 2 Tbsp. freshly grated ginger
  • 4 5oz. skin-on salmon filets
  • 1 small butternut squash, peeled and cubed (around 2 lbs.)
  • 1 lb. Brussels sprouts, ends trimmed and halved (or quartered, if large)
  • 1 Tbsp. extra-virgin olive oil
  • 1/4 tsp. freshly ground black pepper
  • 1 tsp. sesame seeds, for garnish
Makes 4 servings. Per serving: 410 calories, 16 g total fat (2.5 g saturated fat, 0 g trans fat), 80 mg cholesterol, 34 g carbohydrates, 34 g protein, 8 g dietary fiber, 390 mg sodium, 8 g sugar, 3 g added sugar.


  1. Preheat oven to 425°F.
  2. In baking dish, stir together soy sauce, sesame oil, maple syrup, lime juice, red pepper flakes, 1 clove minced garlic and ginger. Place salmon in marinade, skin side up.
  3. Place squash and Brussels sprout in a single layer on baking sheet. Add olive oil and pepper and toss to coat. Place smashed garlic cloves among the vegetables. Roast vegetables for 15 minutes.
  4. Remove from oven and stir, pushing vegetables aside in 4 spots to leave openings for each salmon filet. Place salmon on pan skin side down in the open spaces. Pour any remaining marinade over salmon and return pan to oven for another 12 minutes or until salmon flakes easily with a fork.
  5. Garnish salmon with sesame seeds and serve immediately.


  • You may substitute sweet potatoes for butternut squash and honey for maple syrup (or omit the sweetener entirely).
  • This recipe can also be adapted for different types of fish and vegetable. Less hearty vegetables such as asparagus or green beans will not require as long a cook time.

This recipe contains cancer fighting foods:

This recipe was specially crafted to support cancer prevention and survival. It adheres to AICR's Cancer Prevention Recommendations. Learn more about our recipe guidelines.

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Sheet Pan Salmon with Roasted Veggies

November 6, 2023

Very good and healthy dish. I made it with trout and it still had very good flavor. Loved the sweet and spicy flavor together and also The garlic added in. The recipe made plenty for four people.