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Corporate Champions who partner with the American Institute for Cancer Research stand at the forefront of the fight against cancer

The Continuous Update Project (CUP) is an ongoing program that analyzes global research on how diet, nutrition and physical activity affect cancer risk and survival.

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Whether you are a healthcare provider, a researcher, or just someone who wants to learn more about cancer prevention, we’re here to help.

AICR has pushed research to new heights, and has helped thousands of communities better understand the intersection of lifestyle, nutrition, and cancer.

Read real-life accounts of how AICR is changing lives through cancer prevention and survivorship.

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AICR champions research that increases understanding of the relationship between nutrition, lifestyle, and cancer.

AICR’s resources can help you navigate questions about nutrition and lifestyle, and empower you to advocate for your health.

AICR is committed to putting what we know about cancer prevention into action. To help you live healthier, we’ve taken the latest research and made 10 Cancer Prevention Recommendations.

July 15, 2016 | 2 minute read

Study: Lose weight through diet alone, or with exercise, cut cancer- promoting substances

AICR’s evidence shows that having too much body fat increases risk for eleven cancers. But researchers are looking at whether losing weight, once overweight, would lead to lower risk for these cancers. Now a new study from researchers at Fred Hutchinson Cancer Research Center shows how weight loss – through diet alone or diet and exercise – might change pro-cancer substances in the body.

The 12-month controlled trial of 439 healthy, postmenopausal women with overweight/obesity included 4 randomized groups: calorie restriction diet; moderate activity (goal of 3.75 hours per week), diet and exercise, and no intervention. Researchers wanted to see if these lifestyle changes would affect four substances in the body (biomarkers) that influence formation of blood vessels needed for tumor growth. Fat cell growth also requires a greater blood supply, so these biomarkers are also associated with increasing fat tissue.

After 12 months, women in the exercise group lost 2.4% of their body weight; diet only reduced by 8.5% and those exercising and dieting lost 10.8% of their weight. And the more they lost, the more their biomarkers were reduced.

Women who exercised and dieted lost more weight. The women in the exercise only group did not have significant change in biomarker levels.

This may mean losing weight can lower cancer risk. Lower levels of these substances in the body may make it more difficult for cancer cells and tumors to grow because they aren’t able to get the nutrients they need from blood.

While this study suggests that weight loss in people with overweight and obesity may reduce cancer risk, we need more work to understand the role of these biomarkers, say the study’s authors. And although headlines emphasize weight loss through diet as key in this study, AICR’s evidence shows that getting at least 30 minutes daily of moderate physical activity lowers risk for colorectal, endometrial and breast cancers.

, Study: Lose weight through diet alone, or with exercise, cut cancer- promoting substances

This study was conducted by researchers at Fred Hutchinson Cancer Research Center and supported by grants from the National Cancer Institute and the Breast Cancer Research Foundation.

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