When you include the American Institute for Cancer Research in your estate plans, you make a major difference in the fight against cancer.

Corporate Champions who partner with the American Institute for Cancer Research stand at the forefront of the fight against cancer

The Continuous Update Project (CUP) is an ongoing program that analyzes global research on how diet, nutrition and physical activity affect cancer risk and survival.

A major milestone in cancer research, the Third Expert Report analyzes and synthesizes the evidence gathered in CUP reports and serves as a vital resource for anyone interested in preventing cancer.

Whether you are a healthcare provider, a researcher, or just someone who wants to learn more about cancer prevention, we’re here to help.

AICR has pushed research to new heights, and has helped thousands of communities better understand the intersection of lifestyle, nutrition, and cancer.

Read real-life accounts of how AICR is changing lives through cancer prevention and survivorship.

We bring a detailed policy framework to our advocacy efforts, and provide lawmakers with the scientific evidence they need to achieve our objectives.

AICR champions research that increases understanding of the relationship between nutrition, lifestyle, and cancer.

AICR’s resources can help you navigate questions about nutrition and lifestyle, and empower you to advocate for your health.

AICR is committed to putting what we know about cancer prevention into action. To help you live healthier, we’ve taken the latest research and made 10 Cancer Prevention Recommendations.

April 28, 2014 | 3 minute read

Analysis: Obesity Links to Earlier Mortality for Breast Cancer Survivors

A new study involving the emerging research on lifestyle’s role in breast cancer survivorship suggests that obesity — both before and after a breast cancer diagnosis — is associated with earlier death from cancer or other causes, compared to women at a healthy weight. , Analysis: Obesity Links to Earlier Mortality for Breast Cancer Survivors

The paper was published yesterday in the Annals of Oncology. It adds to a complex and relatively new area of research: what survivors can do to lengthen life and stay healthy.

In a major report on breast cancer survivorship due this Fall, World Cancer Research Fund International’s Continuous Update Project (CUP) expert panel will consider this latest paper as it works to shape official recommendations for cancer survivors. AICR is the US member of World Cancer Research Fund International.

The Annals of Oncology paper was written by a team of scientists involved in the CUP, including Anne McTiernan, MD, PhD, Director of the Prevention Center at the Fred Hutchinson Cancer Research Center. The paper found that “increased body size is significantly related to survival after a diagnosis of breast cancer…” said Dr. McTiernan. But the findings are not proof, she says, more research is needed.

“With regard to purposefully losing weight—we really do need randomized clinical trials before we can definitively say what effect that will have on survival,” says McTiernan, referring to a rigorous method of study considered among the highest levels of proof.

The new paper analyzed the 82 studies that had investigated survival in women with breast cancer and BMI, a measure of body fatness. The studies included approximately 213,000 breast cancer survivors, of which 41,477 of the women died. Sllightly over half died from breast cancer.

The analysis found that women who are obese and develop breast cancer are 41 percent more likely to die earlier than women who are in the normal weight range before diagnosis. Mortality from breast cancer was 35 percent higher for obese women. The increased risk of earlier death was seen for both pre- and post-menopausal cancers. Being overweight also linked to a modest increased risk of an earlier death.

Women who were obese 12 months after diagnosis also had an increased risk of death compared to those at a normal weight.

As the authors of the new paper conclude, these findings are limited by the challenges and limitations of the individual studies. For example, most studies did not adjust for other conditions [comorbidities] and assess intentional weight loss. Another possible limitation the article notes: obese women commonly under-dose their chemotherapy, which may contribute to their increased mortality.

For now, says McTiernan: “I would suggest that [most survivors] try not to gain weight through their treatments, and try to be as physically active as they can tolerate.

“And women should follow as healthy a diet as possible… eat more vegetables and fruits, and lower amounts of high-calorie deserts and sweets. There’s no guarantee these eating styles will improve survival, but they might help women keep their weight stable.”

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