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Research Projects > 1994 Grantees

Regulation of Colonocyte Growth and Differentiation

Project Description

Dr. Barnard investigated the mechanism by which butyrate exerts rapid and potent effects on growth and maturation of colon epithelial cells. This effect appears to be mediated through a key growth-regulating gene, c-myc. Dr. Barnard’s studies sought to increase our understanding of the molecular mechanisms by which butyrate affects c-myc as well as the degree of maturation of the colon epithelial cells.

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