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Research Projects > 1996 Grantees

NPM-RAR, vitamin A, retinoic acid, actue promyelocytic leukemia

Project Description

Based on preliminary results that showed that the specific fusion protein (NPM-RAR) inhibits differentiation of myeloid cells, Dr. Redner continued his investigations into the mechanism whereby NPM-RAR might alter vitamin A signaling and may compete with retinoic acid receptors for binding to a family of proteins which are essential to retinoic acid receptor function.

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