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The Annual AICR Research Conference is the most authoritative source for information on diet, obesity, physical activity and cancer.

The Continuous Update Project (CUP) is an ongoing program that analyzes global research on how diet, nutrition and physical activity affect cancer risk and survival.

A major milestone in cancer research, the Third Expert Report analyzes and synthesizes the evidence gathered in CUP reports and serves as a vital resource for anyone interested in preventing cancer.

AICR has pushed research to new heights, and has helped thousands of communities better understand the intersection of lifestyle, nutrition, and cancer.

Read real-life accounts of how AICR is changing lives through cancer prevention and survivorship.

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AICR champions research that increases understanding of the relationship between nutrition, lifestyle, and cancer.

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AICR is committed to putting what we know about cancer prevention into action. To help you live healthier, we’ve taken the latest research and made 10 Cancer Prevention Recommendations.

Research Projects > 2004 Grantees

Mechanisms of Retinoid Regulation of Anti-Apoptotic Proteins Survivin and Bcl-2

Project Description

These investigations focused on the mechanisms by which the vitamin A derivative, retinoic acid, inhibits the expression of two anti-apoptotic proteins in human estrogen-dependent breast cancer cell lines and thereby promotes apoptosis of the cells. It also examined whether downregulation of expression of the respective genes by retinoic acid improves the cytotoxicity of several chemotherapeutic agents.

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