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Research Projects > 1994 Grantees

Mechanism of Action of Indole-3-Carbinol, a Dietary Chemopreventive Agent in Breast Cancer

Project Description

Dr. Tiwari demonstrated that indole-3-carbinol, a chemopreventive agent present in cruciferous vegetables, reduces the incidence and multiplicity of spontaneous mammary tumors in mice. Dr. Tiwari extended his studies, using estrogen responsive and non-responsive human breast cancer cells, to characterize the novel mechanism of action of indole-3-carbinol in conjunction with estrogen receptors or estradiol responsive factors.

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