Project Description
Dr. Tiwari demonstrated that indole-3-carbinol, a chemopreventive agent present in cruciferous vegetables, reduces the incidence and multiplicity of spontaneous mammary tumors in mice. Dr. Tiwari extended his studies, using estrogen responsive and non-responsive human breast cancer cells, to characterize the novel mechanism of action of indole-3-carbinol in conjunction with estrogen receptors or estradiol responsive factors.