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Research Projects > 2008 Grantees

Interaction Between Vitamin A and Phosphatidylinositol 3-kinase in Colorectal Tumor Metastasis

Project Description

This study tested the hypothesis that retinol (vitamin A) inhibits the metastasis of cancer cells through a unique post-translational mechanism involving inactivation of phosphatidylinositol 3-kinase (PI3K) enzyme. First, the effect was observed in mice consuming diets with vitamin A, and then it examined how vitamin A interacts with PI3K at the molecular level.

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