Project Description
Conjugated linoleic acid (CLA), a family of fatty acids, occurring in dairy products and ruminant meat is a potent inhibitor of mammary carcinogenesis in rats. This study focused on elucidation of the mechanisms for the tumourigenesis stimulatory effects of t10,c12-CLA on erbB2/her2/neu overexpressing mammary epithelium in mice. It investigated the role of stromal-epithelium interactions, the possible role of IGF-1/insulin receptor mediated signal route, and examined the PI3K/AKT/mTOR/CXC4 signal pathway.
