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Research Projects > 1994 Grantees

acute promyelocytic leukemia, retinoic acid, vitamin A, abnormal fusion protein

Project Description

Based on the observation that Acute Promyelocytic Leukemia (APL) can be reversed by treatment with retinoic acid, a natural derivative of vitamin A, Dr. Redner investigated the molecular mechanism underlying the success of this therapy in APL. He sought to determine whether a specific abnormal fusion protein (NPM-RAR) interferes with the function of the normal retinoic acid receptor protein.

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