This study will examine the role of centralized obesity and inflammation in prostate cancer progression. Men with high-grade prostatic intraepithelial neoplasia (HGPIN), which is a marker of prostate cancer susceptibility, will be identified and followed for conversion from HGPIN to prostate cancer. Body composition measurements and blood inflammatory markers will be collected. Study results will provide a comprehensive assessment of immune system regulation associated with centralize fat deposition and conversion from HGPIN to prostate cancer. It aims to elucidate the biological foundation to mediating pathways of prostate cancer progression and potential anti-inflammatory prevention strategies.