Untitled design (65)

AICR champions research that increases understanding of the relationship between nutrition, lifestyle, and cancer.

40 years of progress

Fighting for a better future

Are you ready to make a difference? Join our team and help us advance research, improve cancer education and provide lifesaving resources.

By joining TeamAICR, you’re not just running a race, you’re taking action and working toward a cancer-free future.

Make progress happen with a few simple clicks. Use popular platforms like Facebook to support cancer research and get your friends involved in our mission.

When you include the American Institute for Cancer Research in your estate plans, you make a major difference in the fight against cancer.

Corporate Champions who partner with the American Institute for Cancer Research stand at the forefront of the fight against cancer

40 Years of Progress: Transforming Cancer. Saving Lives.

Innovative Projects Made Possible by Your Generosity

Cancer Update Program – unifying research on nutrition, physical activity and cancer.

AICR champions research that increases understanding of the relationship between nutrition, lifestyle, and cancer.

Read real-life accounts of how AICR is changing lives through cancer prevention and survivorship.

We bring a detailed policy framework to our advocacy efforts, and provide lawmakers with the scientific evidence they need to achieve our objectives.

AICR’s resources can help you navigate questions about nutrition and lifestyle, and empower you to advocate for your health.

Research Projects > 2007 Grantees

Detoxification of the Dietary Carcinogen N-hydroxy-PhIP: Variability in Human Colon and Relevance for Colon Cancer

Project Description

PhIP is a carcinogen formed from a chemical reaction in meat cooked at high temperature, causing colon cancer in rats through conversion to its hydroxylamine metabolite (NHOH-PhIP). This study examined the cellular mechanism by which NHOH-PhIP can be detoxifed by involvement of cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5), while single nucleotide polymorphisms (SNPs) account for variability in response.

Leave a Reply

Your email address will not be published. Required fields are marked *

More News & Updates