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The AICR Lifestyle & Cancer Symposium addresses the most current and consequential issues regarding diet, obesity, physical activity and cancer.

The Annual AICR Research Conference is the most authoritative source for information on diet, obesity, physical activity and cancer.

The Continuous Update Project (CUP) is an ongoing program that analyzes global research on how diet, nutrition and physical activity affect cancer risk and survival.

A major milestone in cancer research, the Third Expert Report analyzes and synthesizes the evidence gathered in CUP reports and serves as a vital resource for anyone interested in preventing cancer.

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AICR has pushed research to new heights, and has helped thousands of communities better understand the intersection of lifestyle, nutrition, and cancer.

Read real-life accounts of how AICR is changing lives through cancer prevention and survivorship.

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AICR champions research that increases understanding of the relationship between nutrition, lifestyle, and cancer.

AICR’s resources can help you navigate questions about nutrition and lifestyle, and empower you to advocate for your health.

AICR is committed to putting what we know about cancer prevention into action. To help you live healthier, we’ve taken the latest research and made 10 Cancer Prevention Recommendations.

Research Projects > 2007 Grantees

Detoxification of the Dietary Carcinogen N-hydroxy-PhIP: Variability in Human Colon and Relevance for Colon Cancer

Project Description

PhIP is a carcinogen formed from a chemical reaction in meat cooked at high temperature, causing colon cancer in rats through conversion to its hydroxylamine metabolite (NHOH-PhIP). This study examined the cellular mechanism by which NHOH-PhIP can be detoxifed by involvement of cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5), while single nucleotide polymorphisms (SNPs) account for variability in response.

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