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Research Projects > 2007 Grantees

Detoxification of the Dietary Carcinogen N-hydroxy-PhIP: Variability in Human Colon and Relevance for Colon Cancer

Project Description

PhIP is a carcinogen formed from a chemical reaction in meat cooked at high temperature, causing colon cancer in rats through conversion to its hydroxylamine metabolite (NHOH-PhIP). This study examined the cellular mechanism by which NHOH-PhIP can be detoxifed by involvement of cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5), while single nucleotide polymorphisms (SNPs) account for variability in response.

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