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Grapes

This content was last updated on January 29, 2020

The Cancer Research

Research is investigating effects of proanthocyanidin compounds from grape seeds and skins. Laboratory studies suggest that they, or compounds gut microbes produce from them, may influence expression of genes related to cancer development. Much work is needed to understand whether this has practical applications in eating habits to reduce cancer risk.

Interpreting the data

After a systematic review of the global scientific literature, AICR/WCRF analyzed how fruits and their nutrients affect the risk of developing cancer.

  • Evidence categorized as “convincing” or “probable” means there is strong research showing a causal relationship to cancer—either decreasing or increasing the risk. The research must include quality human studies that meet specific criteria and biological explanations for the findings.
  • A convincing or probable judgement is strong enough to justify recommendations.
  • There is probable evidence that fruit and non-starchy vegetables combined DECREASE the risk of:
    • cancers of the aerodigestive tract (mouth, pharynx, nasopharynx, larynx, esophagus, lung, stomach, and colorectal cancers)

• Evidence categorized as “limited suggestive” means results are generally consistent in overall conclusions, but it’s rarely strong enough to justify recommendations to reduce risk of cancer.

Limited evidence suggests that fruits may DECREASE the risk of:

  • Lung cancer (in people who smoke or used to smoke tobacco) and squamous cell esophageal cancer

Ongoing Areas of Investigation

  • Laboratory Research
    • Much of the research related to grapes in eating habits to reduce cancer risk involves resveratrol, since grapes are one of a few major food sources. In cell culture studies, resveratrol inhibits all stages of development and progression of various cancers: skin, colorectal, breast, prostate, liver, lung and others. In isolated cells, resveratrol is a powerful antioxidant, directly scavenging free radicals that could damage DNA and stimulating cells’ own antioxidant enzymes. Limited studies in mice and rats show some effects reducing inflammation and cancer development and metastasis, though less consistently.
    • In cell and animal studies, anthocyanins influence cell signaling in ways that increase antioxidant, anti-inflammatory and carcinogen-deactivating enzymes. They inhibit cancer cells’ growth and ability to spread, and activate signaling that leads to self-destruction of abnormal cells.
    • In cell and animal studies, phenolic acids increase cells’ antioxidant and anti-inflammatory defenses against damage that could lead to cancer. Emerging evidence in animal studies suggests they may also improve glucose metabolism and decrease insulin resistance, and alter the gut microbiota (microbes living in the colon), creating an environment in the body less likely to support cancer.
    • In cell and animal studies, flavonols and flavan-3-ols influence gene expression and cell signaling in ways that increase antioxidant, anti-inflammatory and carcinogen-deactivating enzymes. They inhibit cancer cells’ growth and ability to spread, and activate signaling that leads to self-destruction of abnormal Flavonols and flavan-3-ols dial down expression of oncogenes (genes that have potential to cause increased cell growth that can lead to cancer) and increase expression of tumor suppressor genes.
    • In cell studies, proanthocyanidins are antioxidants that seem to influence gene expression to decrease growth of cancer cells and increase their self-destruction. However, this may not reflect effects when they are consumed in food, especially in parts of the body other than the gut.
  • Human Studies

    People who eat more fruit have lower risk of a wide range of cancers. This probably reflects combined protection from many different nutrients and compounds they contain, and how they support overall healthful eating patterns.

    Human clinical trials of resveratrol are very limited. Interpretation of results is complicated, because some studies used grape extracts without noting resveratrol concentrations. And once absorbed, resveratrol is quickly metabolized to other compounds, and excreted. Overall, the absorption and effects of resveratrol seem to vary with the amount consumed, the composition of foods eaten at the same time, and individual differences in the gut microbiota.

    Human studies of how grapes might influence cancer risk are extremely limited. One small, short-term trial showed daily grape juice can decrease free radicals and DNA damage. Women in two case-control studies who consumed the most grapes or resveratrol from grapes had less breast cancer; however, resveratrol from wine was not protective. In a small pilot study, giving colon cancer patients grape powder reduced expression of a tumor-promoting gene in normal colon cells; levels in colon cancer cells did not change, however.

    In an observational (prospective cohort) study of older adults, higher urinary levels of compounds formed from resveratrol — a marker of higher resveratrol consumption – showed no association with markers of inflammation, cancer risk, or longevity after 9 years of follow-up. It’s possible that amounts of resveratrol from dietary habits were not high enough to make a difference. It may also be important that in this study, conducted in a major wine production area of Italy, higher urinary levels of resveratrol-related compounds were strongly linked with greater alcohol consumption.

    Amounts of resveratrol that show potential protective effects in laboratory studies seem to translate to grape consumption beyond amounts likely to be reached through food choices. Benefits are more likely, therefore, to come from overall effects of multiple compounds in grapes and those of many other plant foods.

References

  1. Creasy L, Creasy M. Grape chemistry and the significance of resveratrol: an overview. Pharmaceutical Biology. 1998;36 Supplement:8-13.
  2. Yang J, Xiao Y-Y. Grape Phytochemicals and Associated Health Benefits. Crit Rev Food Sci Nutr. 2013;53:1202-1225.
  3. Bishayee A. Cancer prevention and treatment with resveratrol: from rodent studies to clinical trials. Cancer Prev Res (Phila). 2009;2(5):409-418.
  4. Vervandier-Fasseur D, Latruffe N. The Potential Use of Resveratrol for Cancer Prevention. Molecules. 2019;24(24):4506.
  5. Salehi B, Mishra AP, Nigam M, et al. Resveratrol: A Double-Edged Sword in Health Benefits. Biomedicines. 2018;6(3):91.
  6. Malaguarnera L. Influence of Resveratrol on the Immune Response. Nutrients. 2019;11(5):946.
  7. Duthie SJ. Berry phytochemicals, genomic stability and cancer: Evidence for chemoprotection at several stages in the carcinogenic process. Mol Nutr Food Res. 2007;51(6):665-674.
  8. de Sousa Moraes LF, Sun X, Peluzio MdCG, Zhu M-J. Anthocyanins/anthocyanidins and colorectal cancer: What is behind the scenes? Crit Rev Food Sci Nutr. 2019;59(1):59-71.
  9. Del Rio D, Rodriguez-Mateos A, Spencer JP, Tognolini M, Borges G, Crozier A. Dietary (poly)phenolics in human health: structures, bioavailability, and evidence of protective effects against chronic diseases. Antioxid Redox Signal. 2013;18(14):1818-1892.
  10. Tajik N, Tajik M, Mack I, Enck P. The potential effects of chlorogenic acid, the main phenolic components in coffee, on health: a comprehensive review of the literature. Eur J Nutr. 2017;56(7):2215-2244.
  11. Villa-Rodriguez JA, Ifie I, Gonzalez-Aguilar GA, Roopchand DE. The Gastrointestinal Tract as Prime Site for Cardiometabolic Protection by Dietary Polyphenols. Advances in Nutrition. 2019;10(6):999-1011.
  12. Gibellini L, Pinti M, Nasi M, et al. Quercetin and cancer chemoprevention. Evid Based Complement Alternat Med. 2011;2011:591356.
  13. Montgomery M, Srinivasan A. Epigenetic Gene Regulation by Dietary Compounds in Cancer Prevention. Advances in Nutrition. 2019;10(6):1012-1028.
  14. Li W, Guo Y, Zhang C, et al. Dietary Phytochemicals and Cancer Chemoprevention: A Perspective on Oxidative Stress, Inflammation, and Epigenetics. Chem Res Toxicol. 2016;29(12):2071-2095.
  15. Yang CS, Chen JX, Wang H, Lim J. Lessons Learned from Cancer Prevention Studies with Nutrients and Non-Nutritive Dietary Constituents. Mol Nutr Food Res. 2016;60(6):1239-1250.
  16. Yang CS, Wang X. Green tea and cancer prevention. Nutr Cancer. 2010;62(7):931-937.
  17. Yang CS, Wang X, Lu G, Picinich SC. Cancer prevention by tea: animal studies, molecular mechanisms and human relevance. Nat Rev Cancer. 2009;9(6):429-439.
  18. Lachance JC, Radhakrishnan S, Madiwale G, Guerrier S, Vanamala JKP. Targeting hallmarks of cancer with a food-system–based approach. Nutrition. 2020;69:110563.
  19. de Melo FHM, Oliveira JS, Sartorelli VOB, Montor WR. Cancer Chemoprevention: Classic and Epigenetic Mechanisms Inhibiting Tumorigenesis. What Have We Learned So Far? Frontiers in oncology. 2018;8:644-644.
  20. Casey SC, Amedei A, Aquilano K, et al. Cancer prevention and therapy through the modulation of the tumor microenvironment. Semin Cancer Biol. 2015;35:S199-S223.
  21. Smeriglio A, Barreca D, Bellocco E, Trombetta D. Proanthocyanidins and hydrolysable tannins: occurrence, dietary intake and pharmacological effects. Br J Pharmacol. 2017;174(11):1244-1262.
  22. World Cancer Research Fund / American Institute for Cancer Research. Continuous Update Project Expert Report 2018. Wholegrains, vegetables and fruit and the risk of cancer. Available at: dietandcancerreport.org.
  23. Aune D. Plant Foods, Antioxidant Biomarkers, and the Risk of Cardiovascular Disease, Cancer, and Mortality: A Review of the Evidence. Advances in Nutrition. 2019;10(Supplement_4):S404-S421.
  24. Weiskirchen S, Weiskirchen R. Resveratrol: How Much Wine Do You Have to Drink to Stay Healthy? Advances in Nutrition. 2016;7(4):706-718.
  25. Pezzuto JM. Grapes and human health: a perspective. Journal of Agriculture and Food Chemistry. 2008;56(16):6777-6784.
  26. Nguyen AV, Martinez M, Stamos MJ, et al. Results of a phase I pilot clinical trial examining the effect of plant-derived resveratrol and grape powder on Wnt pathway target gene expression in colonic mucosa and colon cancer. Cancer Manag Res. 2009;1:25-37.
  27. Ramírez-Garza SL, Laveriano-Santos EP, Marhuenda-Muñoz M, et al. Health Effects of Resveratrol: Results from Human Intervention Trials. Nutrients. 2018;10(12):1892.
  28. Park YK, Park E, Kim JS, Kang MH. Daily grape juice consumption reduces oxidative DNA damage and plasma free radical levels in healthy Koreans. Mutat Res. 2003;529(1-2):77-86.
  29. Levi F, Pasche C, Lucchini F, Ghidoni R, Ferraroni M, La Vecchia C. Resveratrol and breast cancer risk. Eur J Cancer Prev. 2005;14(2):139-142.
  30. Do MH, Lee SS, Jung PJ, Lee MH. Intake of fruits, vegetables, and soy foods in relation to breast cancer risk in Korean women: a case-control study. Nutr Cancer. 2007;57(1):20-27.
  31. Semba RD, Ferrucci L, Bartali B, et al. Resveratrol Levels and All-Cause Mortality in Older Community-Dwelling Adults. JAMA Intern Med. 2014;174(7):1077-1084.
  32. Tomé-Carneiro J, Larrosa M, González-Sarrías A, Tomás-Barberán FA, García-Conesa MT, Espín JC. Resveratrol and clinical trials: the crossroad from in vitro studies to human evidence. Curr Pharm Des. 2013;19(34):6064-6093.
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