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Research Projects > 2007 Grantees

Use of the Green Tea Polyphenol, Epigallocatchin-3-gallate, as a Novel Treatment for Trastuzumab Resistant Breast Cancer

Project Description

Trastuzumab has been used in clinical settings to block the HER2/neu activity. This postdoctoral application focused on EGCG and other green tea polyphenols as sensitizers and as effective agents in HER2/neu-resistant breast cancer cells. A mechanistic insight of their effcacy was sought by examination of the EGFR-mediated signalling pathways.

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