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Research Projects > 2019 Grantees

The impact of a cholesterol metabolite on breast cancer dormancy and recurrence.

Research Type: Breast Cancer

Project Description

Breast cancer remains the second leading cause of cancer death in women. Breast cancer can recur many years after completion of therapy, and it is believed that long-dormant cancer cells are responsible. There are no evidence-based strategies to prevent these recurrences. This study seeks to examine how dietary cholesterol, and one of its breakdown products, may allow cells to escape from dormancy. The researchers will use established experimental models of cancer dormancy to determine if increased dietary cholesterol reduces the time that the cancer spends dormant in the body.

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