Research Type: Blood/Bone Marrow/Lymph Cancer
Dr. De Lisio’s project addresses the important issue of late effects of cancer therapy. Specifically, he and his team will evaluate how obesity and exercise mitigate the risk of radiation-induced leukemia. Growing numbers of long-term cancer survivors means that the late effects of therapy, including radiation-induced cancers, are a major health concern. They want to know if obesity increases the risk of developing blood cancers following radiation exposure, and if exercise can mitigate this risk. They will use mice to test the effects of diet-induced obesity and exercise on radiation-induced blood cancer. They expect to identify obesity as a factor that increases radiation-induced blood cancer risk, and introduce exercise as a viable intervention to decrease this risk.