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Research Projects > 1993 Grantees

The Effect of Lactobacillus on Chemically Induced Colon Tumors in the Rats

Project Description

Dr. Goldin has found that if lactobacillus GG, a non-pathogenic bacterium used in the production of dairy products, is fed before and during introduction to a carcinogen in an animal system, it inhibits colon tumor induction. The inhibitory effects were most pronounced when the animals were fed high-fat diets. He studied the mechanisms involved, how lactobacillus changes in composition, and the changes the bacteria cause in the intestine. This might lead to a more effective use of microorganisms in the prevention of colon cancer.

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