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Research Projects > 2020 Grantees

Targeting of leukemia stem cells via activation of GPR44 by dietary selenium

Research Type: Blood/Bone Marrow/Lymph Cancer

Project Description

Relapse of chronic myeloid leukemia (CML) and acute myeloid leukemia (AML) remains a significant concern due to persistent leukemia stem cells (LSC) that are typically not targeted by
existing therapies. This project will examine how selenium, an antioxidant commonly found in many foods, could help existing therapies target LSCs in order to prevent the recurrence of these diseases. The researchers will also examine how non-steroidal anti-inflammatory drugs potentially interfere with the efficacy of selenium in targeting these cells.

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