Research Type: Ovarian Cancer
Ovarian cancer is the leading cause of death from gynecologic cancers. This project will address how obesity affects response to therapy in models of ovarian cancer that has spread. The researchers hypothesize that changes in the body due to obesity will impact how tumors continue to grow and spread in the body. They will test whether diet-induced obesity affects response to the current standard treatment and whether a new combination therapy aimed at blocking fat synthesis and use by tumor cells improves response.