Research Type: Colorectal Cancer
Obese men are more likely to develop colorectal cancer than their female counterparts. Dr. Murphy will examine estrogen’s regulation of inflammation as a potential mechanism for this response. Understanding the mechanisms that drive the sex-specific differences in obesity-enhanced colorectal cancer will help develop targeted treatments. Their hypothesis stipulates that estrogen’s regulation of inflammation is responsible for the sex-specific differences in obesity-enhanced colorectal cancer. Using estrogen manipulation techniques and mouse models, the team will examine the role of estrogen in obesity-enhanced colorectal cancer. The use of hormone replacement therapy to prevent the inflammatory response that is associated with obesity may play a critical role in colorectal cancer prevention.