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Research Projects > 2018 Grantees

Mechanisms underlying the protective effect of exercise on primary mammary tumor growth and metastases: Role of metabolic and immune-mediated processes

Research Type: Breast Cancer

Project Description

This proposal will address the issue of the “dose” or amount of diet and exercise necessary to achieve a cancer prevention effect, specifically with respect to breast cancer prevention. Currently, it is not known how much exercise (dose, duration, frequency) or how much dietary restriction is needed for cancer prevention. Dr. Rogers and her team hypothesize that mild dietary restriction and increased physical activity will have additive effects to prevent breast cancer. They will use an animal model of breast cancer to test our hypotheses and study mechanisms. These studies will provide critical information about the amount of calorie reduction and physical activity necessary to achieve a cancer prevention effect.

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