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Research Projects > 1994 Grantees

Inhibition of DNA Adduct Formation of 2-amino-1-methyl-6-phenylimidazo-(4,5-b)pyridine (PhIP) in the Mammary Gland by Dietary d-Limonene

Project Description

Dr. Schut studied the effect of the dietary constituent, d-Limonene, on the mutagenic potential of charred protein-rich foods. One of the most abundant mutagenic compounds in cooked hamburger meat is PhIP, which has been shown to induce mammary tumors in the rat. Dr. Schut investigated the potential of d-Limonene to inhibit the PhIP formation in the mammary gland. These novel studies aimed to identify a naturally-occurring dietary chemopreventive agent against breast cancer.

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