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Methyl-Groups, Diacylglycerol and Hepatocarcinoma (1992)


Methyl-Groups, Diacylglycerol and Hepatocarcinoma

Key words:

choline deficiency, 1,2-sn-diacylglycerol, protein kinase C

Research Institution:

University of North Carolina at Chapel Hill


North Carolina


Steven H Zeisel

Project Description:

Dr. Zeisel sought to elucidate the role of protein kinase C in carcinogenesis in rats fed diets deficient in choline, a source of methyl groups. This causes accumulation of diacylglycerol in the liver and increased susceptibility to liver cancer.

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