Research Type: Colorectal Cancer
Project Description
Colorectal cancer (CRC) is the second leading cause of cancer death in Mexico with rates increasing, particularly in younger people. Between 2002 and 2021, deaths from CRC increased by 272%, and projections estimate another 141% increase by 2035. Dr. Lajous’ research team will investigate if consuming more fiber in the diet is linked to lower risk of CRC. They will specifically be focusing on early-onset cancers (occurring in younger people) and distal tumors (tumors in the rectum and lower colon) among Mexican women. They will assess the dietary intake of fiber and CRC risk in over 92,000 women, and will also analyze the gut microbiome (diverse bacteria and microbes that live in the gastro-intestinal tract) among a subset of 1,000 women. These microbes help with food digestion and nutrient absorption, but some strains may cause inflammation and disease. This research will provide new insights into early-onset colorectal cancer risk and the potential impact of the microbiome.
