Project Description
Dr. Santella conducted a vitamin intervention study in smokers who took either vitamin C, vitamin E, and beta-carotene or a placebo. Polycyclic aromatic hydrocarbon (PAH)-DNA adducts, an intermediate end point for smoking-induced genotoxic damage, was measured in mononuclear cells and correlated to plasma vitamin levels in order to determine the possible protective effects of these antioxidant vitamins.