Research Type: Breast Cancer
Project Description
Breast cancer is the most commonly diagnosed and second most common cancer-related death among women, with recurrence from metastasis accounting for the majority of deaths. Significant amounts of evidence indicate that dietary and lifestyle can have a lot of influence on breast cancer progression. There is a large and growing population of breast cancer survivors that are seeking evidence-based dietary strategies to improve treatment outcomes and prevent metastatic recurrence. In preclinical models, a metabolic product of cholesterol is known to promote metastasis. Therefore, Dr. Nelson’s group hypothesizes that different cooking strategies for foods high in cholesterol may impact metastatic progression. Using preclinical models of breast cancer, they will evaluate whether metastatic progression is impacted by consuming cholesterol-rich foods prepared in different ways. This study will highlight the potential tumor-promoting attributes of different food preparation techniques and will provide rationale for future trials to evaluate this question in survivors.
