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Research Projects > 2005 Grantees

A Study of Alpha and Gamma Tocopherol and Modulation of PPARs: Chemopreventitives in Colon Cancer

Project Description

This study was designed to determine if gamma-tocopherol, one of the tocotrienols of vitamin E, induces growth arrest and apoptosis in colon cancer cell lines through a peroxisome proliferator activated receptor (PPAR)-gamma mechanism. This research was based on epidemiological studies suggesting that vitamin E negatively correlates with the incidence of colon cancer, and that the anti-proliferative effects of vitamin E are associated with PPAR-gamma.

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