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Research Projects > 1995 Grantees

Short Chain Fatty Acid Metabolism and APC Initiated Colon Cancer

Project Description

Dr. Augenlicht used mice with genes that predispose them to colon cancer to study the molecular mechanism of the protective effects of short chain fatty acids, produced by fermentation of fiber in the intestinal tract. Based on his previous work Dr. Augenlicht tested if short chain fatty acids (SCFAs) correct defects in normal differentiation, mitochondrial gene expression and apoptosis.

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