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Dietary DIM in Pancreatic Cancer Prevention and Therapy (2010)


Dietary DIM in Pancreatic Cancer Prevention and Therapy

Key words:

Diindolylmethane, KLF4, cancer prevention

Research Institution:

University of Texas M.D. Anderson Cancer Center


TexasUnited States


Daoyan Wei

Project Description:

This study is testing the hypothesis that the gene KLF4 plays a critical role in the ability of the dietary compound diindolylmethane (DIM) to prevent and repress tumor activity in pancreatic cancer. Experiments will determine how DIM affects the level and activity of KLF4 in pancreatic cancer cells and in mouse models, and provide information about whether other food components shown to activate KLF4 can be safely used for pancreatic cancer treatment.

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