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Chemoprevention of HER2/NEU Overexpressing Breast Cancer (2008)


Chemoprevention of HER2/NEU Overexpressing Breast Cancer

Key words:

conjucated linoleic acid, her2/neu

Research Institution:

Roswell Park Cancer Institute


New York


Margot M Ip

Project Description:

Conjugated linoleic acid (CLA), a family of fatty acids, occurring in dairy products and ruminant meat is a potent inhibitor of mammary carcinogenesis in rats. This study focused on elucidation of the mechanisms for the tumourigenesis stimulatory effects of t10,c12-CLA on erbB2/her2/neu overexpressing mammary epithelium in mice. It investigated the role of stromal-epithelium interactions, the possible role of IGF-1/insulin receptor mediated signal route, and examined the PI3K/AKT/mTOR/CXC4 signal pathway.

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