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Role of MLH1 Promoter, SNP and Diet in Colon Cancer (2007)


Role of MLH1 Promoter, SNP and Diet in Colon Cancer

Key words:

MLHI-93GA promoter SNP

Research Institution:

Samuel Lunenfeld Research Institute




Bharati Bapat

Project Description:

This study examined how dietary factors interact with the MLHI-93GA promoter SNP functions and affect the etiology of microsatellite instability positive and negative, microsatellite stable colorectal tumors. Colorectal cancer cases from Ontario, Newfoundland and Seattle were included and cell studies used colorectal cancer cell lines. These studies helped to better understand how dietary factors can regulate the contribution of the MLHI-93GA polymorphism to colorectal cancer susceptibility at the population level.

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