| Project Title: | Dietary Lipids and Proliferative Signaling Through p21 ras Proteins |
| Research Institution: | The Cleveland Clinic Foundation |
| State, Country: | OHIO, United States |
| Researchers: | Mladen Golubic M.D. Ph.D. |
| Year: | 1994 |
| Project Description: | Dr. Golubic has demonstrated that some nutritionally relevant fatty acids might activate the cellular p21 ras (c-ras) proteins and pomote cancer development. He will now investigate the possibility that the tumor-enhancing effects of omega-6 polyunsaturated fatty acids and the tumor inhibitory effects of omega-3 polyunsaturated fatty acids may be a consequence of the differential reguation of two important proteins (GAP and neurofibromin) which regulate c-ras. |
