AICR Grants
AICR has funded critical cancer research programs for over 30 years. Use the Search box to find specific grants. You can enter any of the following to help narrow your search:
- Researcher name
- Institution name
- Cancer site (e.g., colorectal or colon, kidney, breast, etc…)
- Food — many of the grants relate to food components and their ability to fight or prevent cancer
- Keywords — other phrases or keywords
| Title | Description | Location | City | State | Country | Researcher | CancerSite | Keywords | Related Foods |
|---|---|---|---|---|---|---|---|---|---|
| Zinc-Cadmium Interactions in Carcinogenesis (1989) | Dr. Schrager studied the levels of zinc in the diet that may be able to block the development of cancer caused by the toxic metal cadmium. | Massachusetts | Massachusetts | Thomas F Schrager, PhD | Esophagus | zinc, cadmium | |||
| Zinc, Metallothionein and Carcinogenesis (1995) | Dr. Lazo studied the biochemical pathway of the inhibitory effect of zinc, an essential micronutrient, in carcinogenesis. Since the metallothionein protein acts as a carrier for metal ions, the presence and inducibility of this protein in various cells and the response to toxicants after exposure to zinc should determined. | Pennsylvania | Pennsylvania | John S Lazo, PhD | Multiple Sites | zinc, metallothionein protein | |||
| Zinc, Its Deficiency and Cancer (1985) | Dr. Falchuk studied the role of zinc, zinc deficiency, and the interaction of zinc with other metals during the growth and development of human colon cancer cells. | Massachusetts | Massachusetts | Kenneth H Falchuk, MD | Colon/Rectum | Zinc | |||
| Zinc as an Activator of the Mitogenic Transactivation Factor c-Jun (1993) | c-Jun is a necessary protein for normal cell division. When cells go through normal cell division they can produce oncoproteins that promote mutations of the protein possibly leading to cancer. Applying excess zinc to normal cells in culture caused more cells than normal to transform to oncoproteins. Dr. Mercola looked at the effect excess zinc has on the transformation of the protein c-Jun. | California | California | Daniel A Mercola, MD, PhD | Other | c-Jun, zinc | |||
| Zinc and Prolactin Regulation of Prostsate Cancer Cell Energy Metabolism (2000) | Dr. Rice tested whether increasing the level of zinc in the culture fluid and adding prolactin will affect the growth and vitality of human prostate cancer cells, and possibly lead to death of the cancer cells. | Florida | Florida | Lori P Rice, PhD | Prostate | Zinc, prolactin | |||
| Whole Food Based Changes in Vitamin A Intake During Adolesence and Subsequent Risk for Mammary Carcinogenesis (2000) | Dr. Schedin fed rats diets of natural foods with different levels of vitamin A precursors to study whether the vitamin influences breast tissue development and has a possible response to a mammary carcinogen. | Colorado | Colorado | Pepper Schedin, PhD | Breast | whole foods | |||
| When Does Phytate Inhibit Colon Tumors and Their Precursors, Aberrant Crypts? (1992) | Dr. Pretlow studied the inhibition of azoxymethane-induced colon carcinogenesis by phytic acid, examining the effects of inhibition of aberrant crypt foci in animals during and after carcinogen administration. | Ohio | Ohio | Theresa P Pretlow, PhD | Colon/Rectum | azoxymethane, phytic acid, aberrant crypt foci, carcinogens, phytate | |||
| Walnut Consumption: Inhibition of Human Prostate Cancer Cell Growth (2009) | Dr. Reiter tested whether walnuts are capable of inhibiting either the onset or growth of human prostate tumors. | Texas | Texas | Russel Reiter, PhD | Prostate | walnuts, vitamin E, melatonin, omega-3 | |||
| Vitamin-D Regulates Inflammatory MicroRNAs in Prostate Cells (2010) | This study is investigating the role of vitamin D in regulating short RNA molecules (called microRNAs) to prevent inflammation, which may help prevent prostate cancer. The laboratory study is using human prostate cells and prostate tissue of patients who have consumed vitamin D as part of a clinical trial. | Illinois | Illinois | Angeline Antonio, PhD | Prostate | ||||
| Vitamin-D Regulates Inflammatory MicroRNAs in Prostate Cells (2010) | This study is investigating the role of vitamin D in regulating short RNA molecules (called microRNAs) to prevent inflammation, which may help prevent prostate cancer. The laboratory study is using human prostate cells and prostate tissue of patients who have consumed vitamin D as part of a clinical trial. | Illinois | Illinois | Angeline Antonio, PhD | Prostate | ||||
| Vitamin-D Regulates Inflammatory MicroRNAs in Prostate Cells (2010) | This study is investigating the role of vitamin D in regulating short RNA molecules (called microRNAs) to prevent inflammation, which may help prevent prostate cancer. The laboratory study is using human prostate cells and prostate tissue of patients who have consumed vitamin D as part of a clinical trial. | Illinois | Illinois | Angeline Antonio, PhD | Prostate | ||||
| Vitamin-D Regulates Inflammatory MicroRNAs in Prostate Cells (2010) | This study is investigating the role of vitamin D in regulating short RNA molecules (called microRNAs) to prevent inflammation, which may help prevent prostate cancer. The laboratory study is using human prostate cells and prostate tissue of patients who have consumed vitamin D as part of a clinical trial. | Illinois | Illinois | United States | Angeline 0 Antonio, Ph.D. | Prostate | 0 | ||
| Vitamin Intervention in Smokers (1995) | Dr. Santella conducted a vitamin intervention study in smokers who took either vitamin C, vitamin E, and beta-carotene or a placebo. Polycyclic aromatic hydrocarbon (PAH)-DNA adducts, an intermediate end point for smoking-induced genotoxic damage, was measured in mononuclear cells and correlated to plasma vitamin levels in order to determine the possible protective effects of these antioxidant vitamins. | New York | New York | Regina M Santella, PhD | Lung | smokers, vitamin C, vitamin E, bet-carotene, polycyclic aromatic hydrocarbon adducts | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Grapefruit, Squash | ||
| Vitamin E and Antiestrogen Responsiveness in Breast Cancer (2003) | Dr. Clarke�s studied whether the response of breast cancer cells to antiestrogens such as tamoxifen are mediated in part by induction of oxidative stress and whether dietary antioxidants including vitamin E can compromise the efficacy of antiestrogen therapy of women with breast cancer. | District of Columbia | District of Columbia | Robert S Clarke, PhD, DSc | Breast | antiestrogens, tamoxifen | |||
| Vitamin Deficiency-Induced Cachexia in Cancer (1984) | Dr. Bernofsky tested his hypothesis that cachexia, the slow wasting away of the body tissues that often accompanies cancer, is caused in part by the tumor destroying certain vitamins needed by the entire body to extract energy from food. | Louisiana | Louisiana | Carl Bernofsky, PhD | Other | vitamin deficiency | |||
| Vitamin D: Biologic Significance in Colon Cancer (1996) | Dr. Evans sought to determine the levels of vitamin D receptors in colon cancer tissues and correlate with prognostic features. In addition, the effect of the active metabolite of vitamin D (1,25-dihydroxyvitamin D3) and its analogs on the growth of human colon cancer xenografts was followed. | District of Columbia | District of Columbia | Stephen R Evans, MD | Colon/Rectum | 1,25-dihydroxyvitamin D3 | |||
| Vitamin D, Sunlight, and Breast Cancer (2010) | Some studies have suggested that the likelihood of developing and dying of breast, colon, and prostate cancer is higher in Northern than in Southern parts of the United States, which is possibly due to the cancer-protective effect of vitamin D. In this animal study, Dr. Epstein is determining the effects of vitamin D produced from sunlight versus vitamin D consumed in the diet on breast cancer, which could translate to protection against other cancers. | California | California | Ervin Epstein, MD | Breast | cancer prevention, ultraviolet radiation | |||
| Vitamin D, Sunlight, and Breast Cancer (2010) | Some studies have suggested that the likelihood of developing and dying of breast, colon, and prostate cancer is higher in Northern than in Southern parts of the United States, which is possibly due to the cancer-protective effect of vitamin D. In this animal study, Dr. Epstein is determining the effects of vitamin D produced from sunlight versus vitamin D consumed in the diet on breast cancer, which could translate to protection against other cancers. | California | California | Ervin Epstein, MD | Breast | cancer prevention, ultraviolet radiation | |||
| Vitamin D, Sunlight, and Breast Cancer (2010) | Some studies have suggested that the likelihood of developing and dying of breast, colon, and prostate cancer is higher in Northern than in Southern parts of the United States, which is possibly due to the cancer-protective effect of vitamin D. In this animal study, Dr. Epstein is determining the effects of vitamin D produced from sunlight versus vitamin D consumed in the diet on breast cancer, which could translate to protection against other cancers. | California | California | Ervin Epstein, MD | Breast | cancer prevention, ultraviolet radiation | |||
| Vitamin D, Sunlight, and Breast Cancer (2010) | Some studies have suggested that the likelihood of developing and dying of breast, colon, and prostate cancer is higher in Northern than in Southern parts of the United States, which is possibly due to the cancer-protective effect of vitamin D. In this animal study, Dr. Epstein is determining the effects of vitamin D produced from sunlight versus vitamin D consumed in the diet on breast cancer, which could translate to protection against other cancers. | California | California | United States | Ervin 0 Epstein, M.D. | Breast | cancer prevention, ultraviolet radiation | ||
| Vitamin D, Polymorphisms, and Lung Cancer Prognosis (2005) | This study investigated the predictive value of 25-hydroxy vitamin D levels and vitamin D receptor polymorphisms in patients with non-small cell lung cancer. Also examined were the relationships between vitamin D and vitamin D receptor polymorphisms on survival rates and cancer recurrence. | Massachusetts | Massachusetts | David C Christiani, MD, MPH | Lung | 25-hydroxyvitamin D, polymorphisms | |||
| Vitamin D Treatment of Prostate Cancer: The Role of IGFBP-3 (2000) | Dr. Feldman explored the role of an insulin-like growth factor binding protein in the anticancer effect of calcitriol (1, 25-dihydroxyvitamin D) and the intermediates involved in order to develop vitamin D therapy for prostate cancer. | California | California | David Feldman, MD | Prostate | insulin-like growth factor, calcitriol | |||
| Vitamin D and Prostate Cancer (1992) | Dr. Feldman studied how a vitamin D deficiency promotes the growth and development of prostate cancer and how vitamin D supplementation might inhibit prostate cancer development and/or progression. Particular attention was on the modification of the vitamin D receptors and the endocrine response. | California | California | David Feldman, MD | Prostate | Vitamin D | |||
| Vitamin D and Prostate Cancer (1994) | Dr. Feldman hypothesized, based on his previous work, that vitamin D deficiency status may promote the development and/or progression of prostate cancer. The effects of vitamin D deficiency, supplementation and use of vitamin D in combination with retinoids were studied in mice grafted with human prostate cancer cell lines. | California | California | David Feldman, MD | Prostate | Retinoids | |||
| Vitamin D and Cyclin D1 Pathways in Oral Carcinogenesis (2010) | This laboratory study is investigating the role of vitamin D in the development of oral cancer and identifying possible mechanisms for its action. The study will focus on the interaction between the vitamin D pathway and cyclin D1, a gene known to play an important role in oral cancer development. | California | California | Sanjay Mallya, PhD | Head and Neck | cyclin D1 | |||
| Vitamin D and Calcium Regulation in Colonic Crypts (1992) | Dr. Davies explored if vitamin D might help regulate and maintain normal calcium levels in colon cells and thereby afford possible protection against colon cancer. | California | California | Richard J Davies, MD | Colon/Rectum | vitamin D, calcium | |||
| Vitamin D and Active Cell Death in Breast Cancer Cells (1993) | Dr. Welsh has shown that vitamin D can stop growth of cells not killed by anti-estrogens such as tamoxifen. She investigated whether combining anti-estrogen and vitamin D might cause more complete and faster tumor regression in breast cancer patients. | Canada | Canada | JoEllen Welsh, PhD | Breast | anti-estrogen | |||
| Vitamin D and Active Cell Death in Breast Cancer Cells (1995) | Dr. Welsh continued her studies on characterizing the effects of the active form of vitamin D and of antiestrogens on various growth factors and in the induction of apoptosis in human breast cancer cell lines and in tumors of mice. | New York | New York | JoEllen Welsh, PhD | Breast | anti-estrogen | |||
| Vitamin D Analogs Enhance the Effectiveness of Fractionated Radiation Therapy in Human Breast Tumor Cells (2000) | Dr. Gupta used an analog of vitamin D, namely EB 1089, to determine whether exposure of human breast cancer cells to EB 1089 along with fractionated radiation will bypass resistance to treatment and lead to death of the tumor cells. | Virginia | Virginia | Mona Sethi Gupta, PhD | Breast | EB1089 anaolg, fractionated radiation | |||
| Vitamin B6 and Colorectal Neoplasia: Modification by Time (2009) | Dr. Lee examined how the intake of vitamin B6 influences colon cancer at various stages of the cancer process. | Massachusetts | Massachusetts | Jung Eun Lee, ScD | Colon/Rectum | colorectal adenoma, cohort study | |||
| Vitamin B6 and Cancer Cells (1987) | Dr. Litwack explored the possibility that vitamin B6 may interfere with the synthesis of compounds which are essential for the development and spread of skin cancer. | Pennsylvania | Pennsylvania | Gerald Litwack, PhD | Skin | synthesis of compounds | |||
| Vitamin A Deficiency and Prostate Cancer (2003) | This study examined the effects of dietary vitamin A defciency on the onset and progression of prostate cancer in a genetically modifed mouse strain. | New York | New York | Max E Gottesman, MD, PhD | Prostate | vitamin A deficiency | |||
| Utilization of Short-Term Microbial Assays to Investigate Dietary Effects on Chemical Carcinogenesis in Rats (1983) | Dr. Rogers and her colleagues studied the effects of diet on pancreatic and liver cancer. | Massachusetts | Massachusetts | Adrianne E Rogers, MD | Liver, Pancreas | pancreas, liver | |||
| Use of the Green Tea Polyphenol, Epigallocatchin-3-gallate, as a Novel Treatment for Trastuzumab Resistant Breast Cancer (2007) | Trastuzumab has been used in clinical settings to block the HER2/neu activity. This postdoctoral application focused on EGCG and other green tea polyphenols as sensitizers and as effective agents in HER2/neu-resistant breast cancer cells. A mechanistic insight of their effcacy was sought by examination of the EGFR-mediated signalling pathways. | Massachusetts | Massachusetts | Nora Mineva, PhD | Breast | HER2/neu, EGCG, green tea polyphenols | |||
| Use of Secoisolariciresinol Diglucoside (SDG) in Radiation Pneumonopathy (2008) | This study examined whether the dietary lignan Secoisolariciresinol Disglucoside (SDG) activates an ARE-reporter transgenic mouse line and protects wt and Nrf-/- mice against radiation-induced lung injury. The experiments sought to provide important new information on whether SDG lignan from flaxseed inhibits radiation-induced pulmonary fibrosis and whether this is likely mediated through the ability of SDG to induce a number of antioxidant genes. | Pennsylvania | Pennsylvania | Melpo Christofidou-Solomidou, PhD | Lung | Secoisolariciresinol Disglucoside (SDG), flaxseed, pulmonary fibrosis | Flaxseed, Legumes (Dry Beans, Peas & Lentils) | ||
| Use of Novel Gentic Mouse Models to Investigate the Health Benefits of Folate in Colon Cancer (2005) | To investigate the folate defciency and increased risk of colon cancer, this study used a mouse model in which there was no folate binding protein to determine how this loss infuences colonic gene expression and DNA methylation following carcinogen (AOM) treatment. | Texas | Texas | Robert S Chapkin, PhD | Colon/Rectum | folate deficiency, gene expression, DNA methylation | Legumes (Dry Beans, Peas & Lentils) | ||
| Use of Novel Genetic Mouse Models to Investigate the Health Benefits of Folate in Colon Cancer (2003) | Dr. Ma studied the role of folate in colon cancer development using mouse models which were deficient in folate transport. | Texas | Texas | David Ma, PhD | Colon/Rectum | folate deficiency | Legumes (Dry Beans, Peas & Lentils) | ||
| Type and Amount of Dietary Fiber in Experimental Colon Cancer (1983) | Dr. Klurfeld studied how different kinds of dietary fiber affect the physiology of the large intestine and the subsequent development of colon cancer. | Pennsylvania | Pennsylvania | David M Klurfeld, PhD | Colon/Rectum | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | |||
| Tumor Radiosensitization by Dietary Quercetin (2003) | These studies were designed to determine whether ingestion of the phytochemical quercetin renders melanoma tumour cells more sensitive to killing by radiation therapy because the ability of tumours to protect against DNA damage is reduced. | Pennsylvania | Pennsylvania | Randy Burd, PhD | Skin | Phytochemicals, quercetin, melanoma | Blueberries, Apples | ||
| Tumor Blood Vessel Maturation by Selenium (2006) | This study investigated the role of selenium on tumor blood vessel maturation, based on the hypothesis that pre-treatment with organoselenium compounds leads to tumor vessel maturation, that this maturation can be assessed non-invasively by functional magnetic resonance, and that it can result in improved drug delivery and therapeutic response. | New York | New York | Arup Bhattacharya, PhD | Other | selenium, tumor blood vessel maturation | |||
| Treatment of Retinoblastoma with Vitamin D Analogues (1991) | Dr. Albert investigated the mechanisms by which different forms of vitamin D inhibit the growth of retinoblastoma, a tumor of the eye that is common in children and can cause blindness and death. | Massachusetts | Massachusetts | Daniel M Albert, MD, MS | Other | retinoblastoma | |||
| Treatment of Cancer Anorexia with a Selective Melanocortin 4 Receptor Antagonist (2003) | These studies focused on determining whether inhibition of melanocortin receptors in the brain can block the cancer anorexia/ cachexia syndrome without altering tumor progression in rodent model systems bearing lung or thymoma tumors. | Washington | Washington | Brent E Wisse, MD | Lung, Thymus | melanocortin receptors, thymoma tumors | |||
| Transgenic fat-1 Mice as a Model for n-3 and n-6 PUFA Modulation of Intestinal Cancer (2004) | This study examined the effects of omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) on the development of intestinal and colon tumours in a transgenic mouse model that can convert omega-6 PUFAs to omega-3 PUFAs. | New York | New York | Sergio A Lamprecht, PhD | Colon/Rectum | omega-3, omega-6 polyunsaturated fatty acids | |||
| Transcriptional Attenuation Induced by Sodium Butyrate and Vitamin D3 in Colon Cancer Cells (2008) | Vitamin D and sodium butyrate, generated by the fermentation of dietary fiber are both regulators of colon maturation and gene expression. They regulate gene expression through a process called transcriptional attenuation. Since the mechanisms of transcriptional attenuation are largely unknown this study sought to examine and characterize the candidate genes for transcriptional attenuation using a novel, custom built microarray analysis to understand the nature and regulatory mechanisms recruited by two nutritional factors that coordinate colonic cell maturation. | New York | New York | Maria Cecilia Daroqui, PhD | Colon/Rectum | Vitamin D, butyrate | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Tomatoes, Broccoli, and Prevention of Prostate Cancer (2001) | Dr. Erdman investigated whether tomatoes or broccoli have a chemopreventive action against prostate cancer in a rat model, with emphasis on transplanted tumors, mediators of antioxidant activity, androgen receptors and vascular endothelial growth factor. | Illinois | Illinois | John W Erdman, PhD | Prostate | tomato, broccoli | Broccoli & Cruciferous Vegetables | ||
| Tocopherol Levels in Alveolar Macrophages & Fluids in Primary Lung Cancer (1990) | Dr. Tangney sought to determine how a dietary supplement of vitamin E might be involved with regulation of the immune system�s ability to fight cancer. Dr. Tangney gave vitamin E capsules to lung cancer patients and to see if there were changes in the levels of lymphokines, which are natural substances in the body that regulate the immune system. | Illinois | Illinois | Christine C Tangney, PhD | Lung | lymphokines, immune system, canecr patients | |||
| Therapy of Neuroblastoma with Retinoic Acid (1992) | Dr. Reynolds investigated whether retinoids might turn off N-myc oncogene expression and thereby inhibit neuroblastoma cell growth in children. He is also exploring whether iron or vitamin E might enhance or otherwise modify the retinoid effect. | California | California | C. Patrick Reynolds, MD, PhD | Nervous System | neuroblastoma, retinoids | Legumes (Dry Beans, Peas & Lentils) | ||
| Therapy of Neuroblastoma with Retinoic Acid (1995) | Dr. Reynolds examined the biology underlying the initial sensitivity and resultant resistance of neuroblastoma cells to retinoic acid. His investigations on the role of retinoic acid receptors and oncogene expression, transcription factors and protein phosphorylation will provide new insights into improving the response of tumors to retinoid treatment. | California | California | C. Patrick Reynolds, MD, PhD | Nervous System | neuroblastoma, retinoic acid | |||
| Therapy of Neuroblastoma with Retinoic Acid (1990) | Dr. Reynolds investigated the possible prevention of the recurrence of neuroblastoma, a common childhood tumor, by treatments with retinoids. He sought to determine the largest dose of retinoids that can be given to children to keep the tumor from growing back and he investigated how the retinoic acid works to prevent tumor growth. | California | California | C. Patrick Reynolds, MD, PhD | Nervous System | neuroblastoma, retinoids | |||
| Therapeutic Synergy Between Piperine and Docetaxel Against Prostate Cancer (2009) | Dr. Uzzo used piperine, a pungent substance found in black peppers, to increase the effectiveness of a widely used prostate cancer chemotherapy. | Pennsylvania | Pennsylvania | Robert G Uzzo, MD | Prostate | piperine, black pepper, docetaxel | |||
| Therapeutic Synergy Between Dietary Calcium and Bacterial Entertoxins for the Prevention and Treatment of Colon Cancer (2010) | This animal study is exploring the hypothesis that the combination between a bacterial toxin and dietary calcium is a novel and potent therapy for colorectal cancer that will suppress tumor formation and growth. | Pennsylvania | Pennsylvania | Giovanni Pitari, MD, PhD | Colon/Rectum | dietary calcium, heat-stable bacterial enterotoxins, calcium-sensing receptor | |||
| Therapeutic Synergy Between Dietary Calcium and Bacterial Entertoxins for the Prevention and Treatment of Colon Cancer (2010) | This animal study is exploring the hypothesis that the combination between a bacterial toxin and dietary calcium is a novel and potent therapy for colorectal cancer that will suppress tumor formation and growth. | Pennsylvania | Pennsylvania | Giovanni Pitari, MD, PhD | Colon/Rectum | dietary calcium, heat-stable bacterial enterotoxins, calcium-sensing receptor | |||
| Therapeutic Synergy Between Dietary Calcium and Bacterial Entertoxins for the Prevention and Treatment of Colon Cancer (2010) | This animal study is exploring the hypothesis that the combination between a bacterial toxin and dietary calcium is a novel and potent therapy for colorectal cancer that will suppress tumor formation and growth. | Pennsylvania | Pennsylvania | Giovanni Pitari, MD, PhD | Colon/Rectum | dietary calcium, heat-stable bacterial enterotoxins, calcium-sensing receptor | |||
| Therapeutic Synergy Between Dietary Calcium and Bacterial Entertoxins for the Prevention and Treatment of Colon Cancer (2010) | This animal study is exploring the hypothesis that the combination between a bacterial toxin and dietary calcium is a novel and potent therapy for colorectal cancer that will suppress tumor formation and growth. | Pennsylvania | Pennsylvania | United States | Giovanni 0 Pitari, M.D., Ph.D. | Colon/Rectum | dietary calcium, heat-stable bacterial enterotoxins, calcium-sensing receptor | ||
| The Use of Transgenic Models to Elucidate the Molecular Mechanism by Which Dietary Restriction Reduces the Occurence of Cancer (1997) | Dr. Heydari investigated whether dietary restriction reduces the incidence of cancer in mice treated with a carcinogen by decreasing the accumulation of DNA damage, presumably because of an increase in DNA repair during dietary restriction. | Texas | Texas | Ahmad R Heydari, PhD | Multiple Sites | dietary restriction, DNA damage | |||
| The Underlying Role of Diet in Breast Cancer Risk (2004) | This study used a rat mammary tumor model to investigate the mechanisms by which dietary exposure to the heavy metals lead and zinc promotes mammary tumour development. | District of Columbia | District of Columbia | Mary Beth Martin, PhD | Breast | lead, zinc | |||
| The Roles of Vitamin A and Retinoic Acid Receptor Beta in Breast Cancer (1998) | Dr. Gudas sought to determine the molecular mechanisms leading to loss of retinoid acid receptor gene expression in mammary carcinoma that results in the insensitivity of the cancer to the growth-inhibitory effects of retinoids. | New York | New York | Lorraine J Gudas, PhD | Breast | retinoic acid | |||
| The Role of the Transcription Factor Rex-1 in Human Breast Cancer (2005) | This study aimed to identify the consensus DNA binding sites for Rex-1, a transcription factor that is highly expressed in normal stem cells, that could play a role in human breast cancer and that is repressed by vitamin A and retinoic acid. | New York | New York | Chunyang Zheng, PhD | Breast | retinoic acid, Rex-1 | |||
| The Role of the Herb Feverfew in preventing CXCR4-Mediated Metastasis of Breast Cancer (2003) | Dr. Nakshatri sought to determine whether a component of the herb feverfew, CXCR4, can synergize with docetaxel and apigenin to inhibit breast cancer metastasis in mice and also to increase the survival of these mice. | Indiana | Indiana | Harikrishna Nakshatri, PhD | Breast | feverfew, CXCR4, docetaxel, apigenin | |||
| The Role of Susceptibility Genes and Dietary Risk Factors in the Etiology of Mutator versus Suppressor Pathway of Colon Cancer (1999) | Dr. Bapat examined samples from a colon cancer registry for the presence of genes that either enhance or decrease the risk of colon cancer, and looked for any dietary connection. | Canada | Canada | Bharati Bapat, PhD | Colon/Rectum | mutator pathway, suppressor pathway, colon cancer registry | |||
| The Role of Skeletal Muscle and Dietary Branched-Chain Amino Acids in Tumor Glutamine Metabolism in Vivo (1994) | Based on observations that rapidly growing tumor cells use glutamine as a major energy source, Dr. Byerley investigated what effect this phenomenon has on glutamine metabolism in the whole body. Since glutamine utilization increases the skeletal muscle breakdown, Dr. Byerley investigated whether this may be prevented by a diet high in three branched-chain amino acids: valine, leucine and isoleucine. | Texas | Texas | Lauri O Byerley, PhD, RD | Other | glutamine metabolism, valine, leucine, isoleucine | |||
| The Role of Nutritional Conditioning and Cellular Adaptation in the Genesis and Suppression of Neoplastic Transformation in Mouse Embryo NIH 3T3 Cells (1992) | Dr. Rubin investigated whether glutamine, a calorie-supplying amino acid, might suppress or reverse the spontaneous transformation of NIH 3T3 cells and whether glutamine restriction might elicit an adaptation and inheritable suppression of transformation in these cells. | California | California | Harry Rubin, DVM | Other | glutamine | |||
| The Role of Nuclear Hormone Receptors in PUFA-Mediated Modulation of Normal Brain and Glioma Cell Catalase Expression (1999) | Dr. Robbins studied whether the ability of dietary polyunsaturated fatty acids (PUFA) to cause the death of brain tumor cells, specifically from gliomas, might be due to an increase in free radical formation, causing lower cell survival and greater radiosensitivity of the PUFA treated cells. | Iowa | Iowa | Michael E Robbins, PhD | Nervous System | PUFAs, glioma | |||
| The Role of Mitochondria in Resveratrol-induced Cell Death of Human Neuroblastoma (2007) | This study assessed whether resveratrol inhibits the growth and prevents the spread of neuroblastoma by interfering with mitochondrial function, leading to loss of membrane potential and activation of the intrinsic apoptosis pathway. | Wisconsin | Wisconsin | Paul van Ginkel, PhD | Nervous System | resveratrol, neuroblastoma, mitochondrial function | Blueberries | ||
| The Role of Lipids in the Proliferative Signal Transduction Through p21 ras Protein (1993) | Dr. Golubic studied the intracellular mechanisms by which dietary fat plays a role in regulating cell division. Dietary fat may interrupt a major regulating protein in cells (c-ras oncogene) allowing the cell to continue to divide uncontrollably and increasing the possibility for cancer to develop. | Ohio | Ohio | Mladen Golubic, MD, PhD | Other | cell division, c-ras oncongene | |||
| The Role of Leisure Physical Activity on Breast Density: a Biomarker Related to Breast Cancer (2010) | Most studies examining the association between physical activity and breast cancer include only middle-aged and older women. This study is using data collected from women in their twenties on physical activity and breast density to determine whether physically activity during adolescence and young adulthood is important to decrease lifetime risk of breast cancer. | Texas | Texas | Kelley Pettee Gabriel, PhD | Breast | health behavior, motor activity, biological marker, breast neoplasms, women | |||
| The Role of Hydroxy Fatty Acids in Skin Tumor Promotion (1991) | Dr. Locniskar studied the metabolism of linoleic acid, a fatty acid, to 13-hydroxyoctadeca dienoic acid (13-HODE) and she evaluated how 13-HODE and related metabolites might prevent skin tumor growth in mice. | Texas | Texas | Mary F Locniskar, PhD | Skin | linoleic acid, 13-HODE | |||
| The Role of Folate Deficiency in Leukemogenesis (1997) | Dr. Koury tested whether the hypothesis that folate deficiency can lead to malignant transformation by using mouse models which provided means to study the phase of the cell affected and the time frame involved. | Tennessee | Tennessee | Mark J Koury, MD | Blood/Bone Marrow/Lymph | folate deficiency, leukemia | Legumes (Dry Beans, Peas & Lentils) | ||
| The Role of Folate Deficiency in Leukemogenesis (1994) | Based on the evidence that suggests that folate-deficient individuals have an increased chance for developing cancer, Dr. Koury investigated whether damage to the genes of the blood-forming cells during folate deficiency leads to the later development of malignant blood-forming cells, i.e. leukemia. | Tennessee | Tennessee | Mark J Koury, MD | Blood/Bone Marrow/Lymph | folate deficiency, leukemia | Legumes (Dry Beans, Peas & Lentils) | ||
| The Role of Dietary Fiber and Gut Microflora in Prevention of Colorectal Cancer (2009) | This study investigated the mechanistic link between dietary fiber, gut microflora, butyrate, and DNA/histone modifications that result in gene expression changes that alter colorectal cancer susceptibility. An inbred strain of genetically-identical mice were maintained with or without intestinal bacteria and provided with two high-fiber diets that produced different levels of butyrate and a low-fiber control diet. A carcinogen was used to induce cancer, and butyrate levels and the number/size of colorectal tumors were scored. | North Carolina | North Carolina | Scott Bultman, PhD | Colon/Rectum | gut microflora, butyrate, DNA/histone, low-fiber diet | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| The Role of Conjugated Dienoic Linoleate in Tumor Promotion (1995) | Dr. Belury studied the mechanisms by which an unsaturated fatty acid derivative or conjugated dienoic linoleate (CLA), formed by combination of several fat components in some meats and cheeses, can afford protection against skin cancer in several animal models. | Indiana | Indiana | Martha A Belury, PhD | Skin | conjugated dienoic linoleate (CLA), meat, cheese | |||
| The Role of Circulating and Cellular Factors involved in Inhibiton of Tumor Proliferation during Dietary Sodium Deprivation (1989) | Dr. Fine sought to determine how a restriction in dietary sodium intake restricts the growth of solid tumors. The effects of dietary sodium deprivation on tumor cell volume, membrane transport, DNA synthesis and other cellular events were studied. | New Jersey | New Jersey | Burton P Fine, MD | Other | sodium, membrane transport, DNA synthesis | |||
| The Role of Caffeine in Breast Tumor Metastasis to the Brain (2009) | Dr. Majewska tested a hypothesis that caffeine's stimulative effect on neurons may play a protective role in keeping breast cancer from spreading to the brain. | New York | New York | Ania Majewska, PhD | Breast | caffeine, neurons, metastasis | Coffee | ||
| The Role of 1,25 Dihydroxyvitamin D and Its Receptor in Epidermal Carcinogenesis (2007) | The goal of this application was to examine how the active vitamin D metabolite 1,25-(OH)2D3, acting through its receptor, suppresses epidermal carcinogenesis by down regulating sonic hedgehog signalling. | California | California | Daniel D Bikle, MD, PhD | Skin | Vitamin D | |||
| The Prevention of Skin Cancer with a Nutritional Supplement of Selenium (1984) | Dr. Smith tested the hypothesis that a dietary supplement of selenium will help prevent recurrent skin cancer. | North Carolina | North Carolina | Cameron L Smith, MD | Skin | Selenium | |||
| The Possible Protective Effects of Dietary and Aerosol Vitamin E and Gluthathione Against Lung Cancer Resulting from Oxidizing Pollutants (1983) | Dr. Alfin-Slater studied whether the addition of vitamin E to the diet could protect the lungs against the cellular damage caused by ozone, a major component of smog and a possible cause of lung cancer. | California | California | Roslyn B Alfin-Slater, PhD | Lung | ozone, glutathione | |||
| The Obesity-Cancer Link: Do Fatty Acids Promote the Tumorigenic Actions of IGF-1? (2005) | The effects of two fatty acids, oleate and palmitate, on the actions of insulin-like growth factor (IGF)-1 in breast cancer cells and in non-malignant breast epithelial cells were examined. IGFs have been strongly implicated as an important risk factor for many common cancers, including breast, and fatty acids are increased in the blood of obese individuals and are known to cause resistance to the actions of insulin. | United Kingdom | United Kingdom | Jeff M.P. Holly, PhD | Breast | oleate, palmitate, insulin-like growth factor, obesity | Legumes (Dry Beans, Peas & Lentils) | ||
| The Nutritional Prevention of Skin Cancer (1988) | Dr. Clark sought to determine whether the risk of developing skin cancer is related to the level of selenium in the blood and if selenium supplementation can prevent the development of skin cancer in patients who have an increased risk of developing non-melanoma skin cancer. | Arizona | Arizona | Larry C Clark, PhD | Skin | selenium | |||
| The Molecular Mechanism of Iron Chelation in Neuroblastoma (1998) | Dr. Fan studied the molecular mechanisms underlying the induction of apoptosis and decreased expression of an oncogene in neuroblastoma cells treated with the iron chelator deferoxamine. | Maryland | Maryland | Liju Fan, PhD | Nervous System | Iron chelator deferoxamine, apoptosis | Legumes (Dry Beans, Peas & Lentils) | ||
| The Modulating Effects of Vitamin A on Hemangioma Cell Growth and Phenotype (1993) | Dr. Braunhut studied the effects of circulating levels of vitamin A in the blood and how they contribute to the growth of normal cells versus hemangioma cells. Hemangioma is a tumor or malformation of blood vessels that may occur in any part of the body. Her goal was to determine whether or not vitamin A can prevent the tumor cells from dividing and spreading to adjacent connective tissue. | Massachusetts | Massachusetts | Susan J Braunhut, PhD | Other | hemangioma | |||
| The Interactive Effect of Retinoic Acid and 1,25()H)2D3 on Tumor Cell Growth (1989) | Dr. Morre investigated how differentiation and cell growth of a tumor cell is altered when cultured in media containing non-toxic amounts of vitamins A and D in combination. | Indiana | Indiana | Dorothy M Morre, PhD | Other | vitamin A, vitamin D, retinoic acid | |||
| The Influence of Vitamin E on the Growth of Human Prostate Cancer (1998) | Dr. Pretlow explored whether vitamin E will inhibit or reverse the growth promoting effect of high fat diets on human prostate cancer. | Ohio | Ohio | Theresa P Pretlow, PhD | Prostate | high-fat diet | |||
| The Influence of Vitamin A on the Regression of Endothelial Cell Tumors (1995) | Dr. Braunhut expanded her studies on the influence of vitamin A on the growth and tumorigenicity of abnormal endothelial cells. The results of these investigations will suggest ways vitamin A contributes to the occurrence of endothelial cell tumors in infants and may lead to a possible treatment of the childhood hemangiomas. | Massachusetts | Massachusetts | Susan J Braunhut, PhD | Other | hemangioma | |||
| The Influence of Phytoestrogens and Estrogen on Colon Cancer in Estrogen Receptor Knockout Mice (2000) | Dr. MacDonald investigated the response of mice lacking estrogen receptors to treatment with phyto- and conjugated estrogens, along with injections of a colon carcinogen. | Missouri | Missouri | Ruth S MacDonald, PhD, RD | Colon/Rectum | phytoestrogens, conjugated estrogens | |||
| The Influence of Dietary Fat on Mammary Tumorigenesis and RAS Oncogene mRNA Levels in MMTV/V-Ha-ras Transgenic Mice (1990) | Dr. DeWille evaluated how dietary fat might influence the inherited tendency to develop breast cancer. He investigated whether fat might activate the specific gene that is responsible for inherited breast cancer. | Ohio | Ohio | James W De Wille, PhD, MPH | Breast | inherited breast cancer gene, RAS oncongene | |||
| The Function of PML-RARx During All-trans Retinoic Acid Induced Differentiation in Acute Promyelocytic Leukemia (2001) | Dr. Jing studied further the relationship between cathepsin B induction by trans-retinoic acid and the cleavage of certain retinoic acid receptors, leading to differentiation of acute promyelocytic leukemia cells. | New York | New York | Yongkui Jing, PhD | Blood/Bone Marrow/Lymph | cathepsin B, trans-retinoic acid, acute promylocytic leukemia | |||
| The Efficacy of Diet and Chemopreventatives on Cancer Progression in a Novel Mouse Model Mimicking Human Tumorigenesis (1998) | Dr. Sharp investigated the chemopreventive effect of diet restriction and feeding of the phytoalexin resveratrol from grapes, either alone or in combination, on tumor formation in mice which develop pituitary and/or thyroid tumors spontaneously. | Texas | Texas | Z. Dave Sharp, PhD | Nervous System | phytoalexin, resveratrol, grapes, thyroid tumors | Blueberries | ||
| The Effects of Retinoids on the Neovascularization of Mammary Tumors (1998) | Dr. Braunhut studied dietary forms of vitamin A and its precursors or derivatives which inhibit blood vessel formation in various human breast cancer models, as a means to inhibit cancer growth. | Massachusetts | Massachusetts | Susan J Braunhut, PhD | Breast | blood vessel formation | |||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | 0 | Maryland | Maryland | United States | Paul Talalay, Ph.D. | Skin | 0 | ||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | 0 | Maryland | Maryland | Paul Talalay, PhD | Skin | ||||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | Maryland | Maryland | Paul Talalay, Ph.D. | Skin | Broccoli & Cruciferous Vegetables | ||||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | Maryland | Maryland | Paul Talalay, Ph.D. | Skin | Broccoli & Cruciferous Vegetables | ||||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | 0 | Maryland | Maryland | Paul Talalay, PhD | Skin | ||||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | 0 | Maryland | Maryland | Paul Talalay, PhD | Skin | ||||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | Maryland | Maryland | Paul Talalay, Ph.D. | Skin | Broccoli & Cruciferous Vegetables | ||||
| The Effects of Glucosinolates on Polyps in Min Mice and the Prevention of UV-induced Skin Tumor in Hairless Mice (2004) | Maryland | Maryland | Paul Talalay, Ph.D. | Skin | Broccoli & Cruciferous Vegetables | ||||
| The Effects of Folate on Intestinal Carcinogenesis in Genetically Predisposed Murine Models (1998) | Dr. Kim explored the effect of folate in a mouse intestinal carcinogenesis model to elucidate further the possible role of methylation in the process. | Canada | Canada | Young-In Kim, MD, FRCPC | Colon/Rectum | folate, methylation | Legumes (Dry Beans, Peas & Lentils) | ||
| The Effects of Dietary Selenium Supplementation on Breast Cancer Metastasis (2009) | Dr. Mastro examined the mineral selenium and its effect on breast cancer's ability to spread to the rest of the body. | Pennsylvania | Pennsylvania | Andrea M Mastro, PhD | Breast | selenium, metastasis | |||
| The Effects of Dietary Fats on the Progression of Prostate Cancer (1997) | Dr. Grizzle explored the effects of dietary corn oil, linseed oil, or butter on the growth of three human prostatic cancer lines which were xenotransplanted into mice, based on the hypothesis that dietary fat levels influence risk of prostatic cancer. | Alabama | Alabama | William E Grizzle, MD, PhD | Prostate | Corn oil, linseed oil, butter | |||
| The Effects of Caloric Restriction on Chemically Induced Mutagenesis in the Rat (1999) | Dr. De Boer examined the effects of a calorie-restricted diet in modulating the action of a chemical mutagen in rats. | Canada | Canada | Johan G De Boer, PhD | Colon/Rectum, Liver | caloric restriction | |||
| The Effects of Caffeine on Chemotherapy and Multi-Drug Resistance in Cancer (2005) | This postdoctoral study examined the effect of caffeine on multidrug resistance (MDR) by investigating the transcriptional regulation of the MDR1 gene and its gene product P-glycoprotein in the presence of caffeine. | New Jersey | New Jersey | Pellegrino V Magro, PhD | Other | caffeine, multidrug resistance, P-glycoprotein | Coffee | ||
| The Effects of a Low-Fat, High-Carbohydrate Diet on Ovarian Function in Premenopausal Women (1996) | Dr. Boyd conducted a dietary intervention study in which breast cancer risk was be followed as part of a ten-year study of women on a low-fat, high-carbohydrate diet, with concurrent measurement of various serum hormones. | Canada | Canada | Norman F Boyd, MD, DSc, FRCPC | Breast | low-fat, high-carbohydrate diet, dietary intervention study | |||
| The Effectiveness of the Neutropenic Diet in Pediatric Oncology Patients" (2010) | This multi-center clinical trial is determining the effectiveness of the neutropenic diet versus a liberalized diet in reducing infection rate among children with cancer and to identify the effects of the diets on the children�s health related quality of life and nutritional status. The goal of the study is to develop dietary guidelines for children with cancer that promote health related quality of life, attenuate treatment toxicity, and improve overall survival. | New York | New York | Karen Moody, MD, MS | Other | children, neutropenia, white blood cell count diet, low-bacterial diet, nutrition, obesity | |||
| The Effect of the Form and Level of Selenium on Murine Mammary Gland Gluthathione Levels and Tumor Incidence (1983) | Dr. Lane studied if the chemical forms of selenium commonly found in foods can prevent the development of breast cancer and how and when this preventive effect might occur. | Alabama | Alabama | Helen W Lane, PhD | Breast | Selenium | |||
| The Effect of Phytoestrogens on Normal Breast Tissue in Post menopausal Women: A Randomized Double-Blind Placebo-Controlled Trial (2000) | Dr. Palomares studied whether breast density in postmenopausal women with early breast cancer can be correlated with oral intake of phytoestrogens daily over a period of one year. | Washington | Washington | Melanie R Palomares, MD | Breast | phytoestrogens, breast density, postmenopausal breast cancer | |||
| The Effect of Lactobacillus on Chemically Induced Colon Tumors in the Rats (1993) | Dr. Goldin has found that if lactobacillus GG, a non-pathogenic bacterium used in the production of dairy products, is fed before and during introduction to a carcinogen in an animal system, it inhibits colon tumor induction. The inhibitory effects were most pronounced when the animals were fed high-fat diets. He studied the mechanisms involved, how lactobacillus changes in composition, and the changes the bacteria cause in the intestine. This might lead to a more effective use of microorganisms in the prevention of colon cancer. | Massachusetts | Massachusetts | Barry R Goldin, PhD | Colon/Rectum | lactobacillus | |||
| The Effect of Lactobacillus on Chemically Induced Colon Tumors in the Rat (1990) | Dr. Goldin investigated whether lactobacillus, strains of bacteria used to produce yogurt, might lower colon cancer risk. He sought to determine whether these bacteria might prevent chemicals in the colon from being converted to cancer-causing agents. | Massachusetts | Massachusetts | Barry R Goldin, PhD | Colon/Rectum | lactobacillus | |||
| The Effect of Diet on Change in Mammographic Densities at the Menopause (1999) | Dr. Boyd continued a study in which low fat and high carbohydrate diets lead to a decrease in breast mammographic density in postmenopausal women. | Canada | Canada | Norman F Boyd, MD, DSc, FRCPC | Breast | low-fat, high-carbohydrate diet, breast density | |||
| The Effect of Anitoxidant and Dietary Restriction on the Development of Spontaneous Tumors in Heterozygous MnSOD Knockout Mice (2001) | Dr. Ikeno examined the effects of caloric restriction and supplementation with vitamin E on spontaneous tumors and DNA damage in a mouse model. | Texas | Texas | Yuji Ikeno, MD, PhD | Multiple Sites | vitamin E, caloric restriction, DNA damage, oxidative stress | |||
| The Effect of Altered Levels of Cellular Retinoic Acid Binding Proteins on Retinoid Metabolism (1998) | Dr. Roman studied the extent to which cellular retinoic acid binding proteins act as regulatory proteins in cancerous states by monitoring cellular retinoic acid levels and controlling the synthesis or degradation of retinoic acid through interaction with specific cellular proteins. | Maryland | Maryland | Laura M Roman, PhD | Other | retinoic acid | |||
| The Effect of a Lycopene-rich Tomato Extract on Gene Expression in Benign Prostate Tissue: Results from a Randomized Trial in Men with HGPIN (2009) | Dr. Gann examined the effect of lycopene on gene expression in human prostate to shed light on potential chemopreventive activity of lycopene-containing foods. | Illinois | Illinois | Peter H Gann, MD, ScD | Prostate | lycopene, vitamin B6 | Broccoli & Cruciferous Vegetables, Coffee, Legumes (Dry Beans, Peas & Lentils), Grapefruit | ||
| The Effect of 1,25 Dihydroxyvitamin D3 on Episomal DNA (1988) | Dr. Von Hoff explored the possibility that vitamin D halts the growth of cancer by eliminating a tumor�s episomes, which are extra genes that either trigger the development of cancer or provide resistance to chemotherapeutic drugs. | Texas | Texas | Daniel D Von Hoff, MD | Multiple Sites | 1,25 dihydroxyvitamin D3, episomes | |||
| The Development of Methionine-Deprivation Dietary Therapy for Human Cancer (1985) | Dr. Hoffman continued to develop a dietary and chemotherapeutic treatment for certain cancers that cease to grow and become more vulnerable to drugs when they are deprived of the amino acid methionine. | California | California | Robert M Hoffman, PhD | Skin | methionine | |||
| The Application of the New American Plate to the Guatemalan Diet (2003) | 0 | Guatemala | Guatemala | Noel Solomons, M.D. | Other | 0 | |||
| The Application of the New American Plate to the Guatemalan Diet (2003) | 0 | Guatemala | Guatemala | Noel Solomons, MD | Other | ||||
| The Application of the New American Plate to the Guatemalan Diet (2003) | 0 | Guatemala | Guatemala | Noel Solomons, MD | Other | ||||
| The Application of the New American Plate to the Guatemalan Diet (2003) | 0 | Guatemala | Guatemala | Noel Solomons, MD | Other | ||||
| The Alpha Tocopherol Transfer Protein, Vitamin E and Prostate Cancer (2009) | Dr. Morley tested whether vitamin E can make prostate cancer cells more sensitive to treatment. | Massachusetts | Massachusetts | Samantha Morley, PhD | Prostate | alpha tocopherol transfer protein, dietary intervention | |||
| Telephone vs. In-person Weight Loss Counseling on Weight, Body Fat and Serum Hormones in Breast Cancer Survivors (2010) | This study is testing the effectiveness of two different weight loss counseling approaches among women with breast cancer: in-person versus telephone-based. Along with weight loss, the study will examine the cost-effectiveness of each program and the effect of weight loss on biological markers associated with prognosis. | Connecticut | Connecticut | Melinda Irwin, PhD, MPH | Breast | obesity, diet, physical activity, exercise, prognosis, survival, telephone, cost effective | |||
| Targeting of cFLIP by Lupeol, a Dietary Triterpene, for the Chemoprevention of Pancreatic cancer (2009) | Dr. Bhat examined the ability of a compound called lupeol, found in figs, mangoes, olives, strawberries and grapes, to make pancreatic cancer cells more responsive to chemotherapy. | Minnesota | Minnesota | Mohammad Saleem Bhat, PhD | Pancreas | lupeol, figs, mangoes, olives, strawberries, grapes | |||
| Synergy Between Two Phytochemicals in Cruciferous Vegetables in the Prevention of Cancer (2000) | Dr. Wallig investigated whether two different activated compounds produced by eating cruciferous vegetables can have synergistic cancer protective effects greater than by either compound alone. | Illinois | Illinois | Matthew A Wallig, PhD, DVM | Liver | cruciferous vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Synergistic Inhibition of Colon Carcinogenesis by 5-hydroxyl Nobiletin and Atorvastatin (2010) | This animal study is exploring the possible synergistic effect of the dietary flavonoid 5-hydroxyl nobiletin, a compound found in oranges, with a common lipid-lowering drug on colon cancer development. | Massachusetts | Massachusetts | Hang Xiao, PhD | Colon/Rectum | 5-hydroxyl nobiletin, synergy, atorvastatin, orange | |||
| Suppression of Tumorigenesis by N-3 Fatty Acids (1998) | Dr. Hwang studied whether fatty acids from fish oils have a protective effect against cancer by inhibiting a key enzyme which may be involved in the oxidative processes associated with carcinogenesis. | Louisiana | Louisiana | Daniel Hwang, PhD | Colon/Rectum | fish oil | |||
| Suppression of Tumorigenesis by n-3 Fatty Acids (2001) | Dr. Hwang studied the efficacy of n-3 fatty acids in inhibiting tumor cells with PPAR (peroxisome proliferator activated receptors) transcription factors. | Louisiana | Louisiana | Daniel Hwang, PhD | Colon/Rectum | PPAR | |||
| Supplemental Vitamin A Diet as an Adjunct to Radiotherapy of Cancer (1984) | Dr. Mendecki examined whether supplemental vitamin A in the diet can prevent the development of cancer, improve the success of cancer treatment, and help to avoid some of the side effects of radiation therapy. | New York | New York | Jozef Mendecki, PhD | Other | vitamin A supplements, radiation therapy side effects | |||
| Studies on the Possible Linkage Between the Delivery and Metabolism of Dietary Retinoid to Bone Marrow and Acute Promyelocytic Leukemia (1992) | Dr. Blaner investigated whether all-trans retinoic acid, an active form of vitamin A, might be increased in circulation, bone marrow, and tissues by increasing the amounts of dietary retinol or beta-carotene and other forms of vitamin A during the treatment of acute promyelocytic leukemia (APL). | New York | New York | William S Blaner, PhD | Blood/Bone Marrow/Lymph | retinoic acid, retinol, beta-carotene, acute promyelocytic leukemia | Grapefruit | ||
| Studies on In Vivo Nitrosation (1991) | Dr. Mirvish investigated in human volunteers and in rats how vitamin C from dietary fruits and vegetables inhibits the formation of nitrosamines. He measured 3-methyladenine in the urine as a possible indicator of increased risk for cancers of the stomach and esophagus. This substance is formed when nitrosamines attack DNA. | Nebraska | Nebraska | Sidney S Mirvish, PhD | Stomach | fruits, vegetables, nitrosamines, 3-methyladenine | Cranberries, Apples, Squash, Cherries | ||
| Studies On a New Retinoid-Binding Protein - Ret BP (1993) | Dr. Sani discovered a new retinoid binding protein (Ret BP) that binds to Vitamin A and that may play a key role in cancer prevention and treatment. Dr. Sani utilized current technology to learn more about Ret BP�s function, chemical composition and the mechanism by which this protein works in both cell cultures and animals. | Alabama | Alabama | Brahma P Sani, PhD | Other | Ret BP | |||
| Strategies for Colon Cancer Prevention with Transgenic Alfalfa: Resveratrol Glucoside (2003) | Dr. Birt�s studies were designed to develop strategies for improving the colon cancer potential of resveratrol. Studies were conducted in laboratory animals using free resveratrol and by resveratrol in the form that accumulates in transgenic alfalfa (resveratrol glucoside) | Iowa | Iowa | Diane F Birt, PhD | Colon/Rectum | resveratrol, alfalfa | Blueberries | ||
| Specific Role of Genistein in Reducing Hormonal and Proliferative Risk Parameters in Prostate Cancer (1999) | Dr. Kumar explored whether supplementation of the diets of prostate cancer patients with the soy isoflavone, genistein, will lead to a decrease in the levels of biomarkers which are indicative of a risk for prostate cancer. | Florida | Florida | Nagi B Kumar, PhD, RD, FADA | Prostate | Genistein | |||
| Soybean Diet and Breast Cancer Prevention (1995) | Dr. Lu assessed the effect of a soy milk dietary supplement, given to premenopausal women, on levels of ovarian hormones and other parameters of hormonal function, to furnish information on diets that may protect against breast cancer. | Texas | Texas | Lee-Jane W Lu, PhD | Breast | soy milk, ovarian hormones | |||
| Soybean Consumption and Colon Cancer Prevention - Studies in a Mouse Model and in Human Colon Cells (2003) | These studies were designed to examine whether soybean consumption can enhance vitamin D synthesis in colon cells due to its high phytoestrogen content and whether this subsequently prevents the occurrence of premalignant changes in the colon. | Austria | Austria | Heide S Cross, PhD | Colon/Rectum | soybeans, phytoestrogen | Legumes (Dry Beans, Peas & Lentils) | ||
| Soy Sphingadienes and Related Compounds in Colon Cancer Chemoprevention and Treatment (2009) | Dr. Saba studied the ability of substances found in soy to kill colon cancer cells without damaging healthy cells. | California | California | Julie Saba, MD, PhD | Colon/Rectum | sphingadienes, soy, fat | |||
| Soy Products And Experimental Bladder Cancer (2000) | Dr. Clinton investigated the effects of soy products on growth of transplantable bladder carcinomas in mice, under the premise that soy products reduce the levels of some cell growth factors and lead to death of tumor cells. | Ohio | Ohio | Steven K Clinton, MD, PhD | Bladder | soy | |||
| Soy Isoflavones to Protect Normal Lung During Radiotherapy of Lung Cancer (2010) | This animal study is investigating the capability for the natural isoflavones contained in soybeans to protect normal lung against radiation injury, while at the same time enhancing the effect of the radiotherapy against tumor cells. Dr. Hillman will conduct first cell then animal studies to determine the most effective combinations of radiation and soy isoflavones to improve lung cancer treatment. | Michigan | Michigan | Gilda Hillman, PhD | Lung | Soy isoflavones, radiotherapy | |||
| Soy Isoflavones to Protect Normal Lung During Radiotherapy of Lung Cancer (2010) | This animal study is investigating the capability for the natural isoflavones contained in soybeans to protect normal lung against radiation injury, while at the same time enhancing the effect of the radiotherapy against tumor cells. Dr. Hillman will conduct first cell then animal studies to determine the most effective combinations of radiation and soy isoflavones to improve lung cancer treatment. | Michigan | Michigan | Gilda Hillman, PhD | Lung | Soy isoflavones, radiotherapy | |||
| Soy Isoflavones to Protect Normal Lung During Radiotherapy of Lung Cancer (2010) | This animal study is investigating the capability for the natural isoflavones contained in soybeans to protect normal lung against radiation injury, while at the same time enhancing the effect of the radiotherapy against tumor cells. Dr. Hillman will conduct first cell then animal studies to determine the most effective combinations of radiation and soy isoflavones to improve lung cancer treatment. | Michigan | Michigan | Gilda Hillman, PhD | Lung | Soy isoflavones, radiotherapy | |||
| Soy Isoflavones to Protect Normal Lung During Radiotherapy of Lung Cancer (2010) | This animal study is investigating the capability for the natural isoflavones contained in soybeans to protect normal lung against radiation injury, while at the same time enhancing the effect of the radiotherapy against tumor cells. Dr. Hillman will conduct first cell then animal studies to determine the most effective combinations of radiation and soy isoflavones to improve lung cancer treatment. | Michigan | Michigan | United States | Gilda 0 Hillman, Ph.D. | Lung | Soy isoflavones, radiotherapy | ||
| Soy Isoflavone As A Radiation Sensitizer in Prostate Cancer (1998) | Dr. Zhou explored the hypothesis that radiation in combination with dietary isoflavones from soy are synergistic against human prostate cancer cells, carried as xenographs in mice. | Massachusetts | Massachusetts | Jin-Rong Zhou, PhD | Prostate | dietary isoflavones, soy | |||
| Soy Foods, Isoflavones, Insulin-like Growth Factor I, and Breast Cancer Risk (2002) | Dr. Maskarinec used serum samples and data from several dietary surveys to determine whether insulin-like growth factor is associated with diet, soy intake, increased density in mammograms and other risk factors for breast cancer. | Hawaii | Hawaii | Gertraud Maskarinec, PhD, MD | Breast | insulin-like growth factor, diet, soy | |||
| solation and Identification of Anticarcinogenic Minor Dietary Component (1985) | With the use of a new, rapid assay developed with earlier support from AICR, Dr. Talalay continued his systematic identification of the substances found naturally in vegetables which are capable of stimulating the deactivation of carcinogens. | Maryland | Maryland | Paul Talalay, PhD | Liver | vegetables, carcinogens | Squash | ||
| Sinigrin as Anticarcinogen to Nitrosamines (1984) | Dr. Chung tested whether a compound found in cruciferous vegetables, sinigrin, can prevent the development of liver, lung, and nasal tumors caused by exposure to a powerful carcinogen present in tobacco. | New York | New York | Fung-Lung Chung, PhD | Liver, Lung | sinigrin, cruciferous vegetables, liver, lung, nasal tumors, tobacco | Broccoli & Cruciferous Vegetables, Squash | ||
| Short-Term Leucine Restriction for Complementary Therapy of Breast Cancer (2005) | This study examined whether dietary restriction of leucine increases the efficacy of breast cancer therapy by down-regulating the mTor/ S6K1 signalling pathway, which is activated in about 50% of breast cancers and correlates with poor prognosis. | Texas | Texas | Funda Meric-Bernstam, MD | Breast | leucine | |||
| Short-chain Fatty Acids: Molecular Mechanism of Action (1999) | Dr. Mariadason studied the effect of short-chain fatty acids on the cell cycle, specifically with reference to a possible role of histone deacetylase and its inhibition in the action of butyrate. | New York | New York | John Mariadason, PhD | Colon/Rectum | histone deacetylase, butyrate | |||
| Short Chain Fatty Acid Metabolism and APC Initiated Colon Cancer (1995) | Dr. Augenlicht used mice with genes that predispose them to colon cancer to study the molecular mechanism of the protective effects of short chain fatty acids, produced by fermentation of fiber in the intestinal tract. Based on his previous work Dr. Augenlicht tested if short chain fatty acids (SCFAs) correct defects in normal differentiation, mitochondrial gene expression and apoptosis. | New York | New York | Leonard H Augenlicht, PhD | Colon/Rectum | fiber, short chain fatty acids | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Sequelae of Adiposity in the Etiology of Colorectal Neoplasia (2003) | Dr. Platz investigated whether obesity can influence the development of adenomatous polyps and colon cancer as a result of cell inflammation. | Maryland | Maryland | Elizabeth A Platz, PhD | Colon/Rectum | obesity, adenomatous polyps, cell inflammation | |||
| Sensitizing Cancer for Chemotherapy (1998) | Dr. Hardman tested the hypothesis that treatment of tumor cells with n-3 fatty acids and iron will sensitize the tumor cells to chemotherapy without affecting normal cells. | Texas | Texas | W. Elaine Hardman, PhD | Breast | n-3 fatty acids | Legumes (Dry Beans, Peas & Lentils) | ||
| Selenium Protection from Chemotherapeutic Toxicity (2004) | This study investigated the molecular mechanisms involved in the protection by selenium of normal bone marrow and gut epithelium cells from chemotherapeutic toxicity during treatment of colon and squamous cell carcinomas by the chemotherapeutic drug irinotecan. | Indiana | Indiana | Martin L Smith, PhD | Colon/Rectum | selenium, irinotecan | |||
| Selenium Inhibition of Breast Cancer (1985) | Dr. Medina studied a group of selenium-containing proteins found in breast cells which may be involved in regulating the growth and proliferation of pre-cancerous cells. | Texas | Texas | Daniel Medina, PhD | Breast | selenium | |||
| Selenium and Prostate Cancer (2002) | Dr. Sytkowski studied the human selenium binding protein (hsp 56) that is expressed in prostate cancer cell lines to determine its cellular and molecular properties and its biological action, its effect on growth of tumor cells in mice and its distribution in both prostate tumors and normal cells. | Massachusetts | Massachusetts | Arthur J Sytkowski, MD | Prostate | human selenium binding protein (hsp 56) | |||
| Selenium and Prostate Cancer (1999) | Dr. Stykowski investigated the mechanism by which dietary selenium suppresses prostate cancer, presumably through a selenium binding protein that may be a growth-regulating protein, which is deficient in prostate cancer cells. | Massachusetts | Massachusetts | Arthur J Sytkowski, MD | Prostate | dietary selenium | |||
| Selenium and Osteoblast Involvement in Breast Cancer Metastases in Bone (2006) | This study investigated how selenium affects the interaction of osteoblasts and breast cancer cells. | Pennsylvania | Pennsylvania | Andrea M Mastro, PhD | Breast | selenium, osteoblasts, metastasis | |||
| Selective Reduction of cis-Platinum Toxicity by Selenium Supplementation (1987) | Dr. Magin studied how a dietary supplement of the mineral selenium may be able to reduce the toxic side effects of the anti-cancer drug cis-diamminedichloroplatinum and improve this drug�s effectiveness. | Illinois | Illinois | Richard L Magin, PhD | Other | selenium, cis-diamminedichloroplatinum | |||
| Selective Inhibition of DMBA-DNA Adducts by Selenium Supplementation (1985) | Dr. Milner studied how the mineral selenium interferes with the initiation of cancer in the breast cells and in the embryo cells of mice. | Illinois | Illinois | John A Milner, PhD | Breast | selenium | |||
| Saturated Fatty Acids Regulate DNA Synthesis via Growth Factor Receptor Associated G-Proteins (1993) | In the body, G-proteins translate signals within the cell membrane and are part of normal cell function. Dr. Hardy studied whether palmitate, a saturated fatty acid that regulates G-proteins, plays a role in the development or prevention of cancer. | Alabama | Alabama | Robert W Hardy, PhD | Other | G-protein, palmitate | |||
| Saturated Fatty Acids Regulate DNA Synthesis Via Growth Factor Receptor Associated G-Proteins (1995) | Dr. Hardy further examined the inhibitory action of dietary long chain saturated fatty acids, specifically stearic acid, on breast cell proliferation and tumorigenesis since this fatty acid disrupts cell proliferation initiated by epidermal growth factor (EGF). | Alabama | Alabama | Robert W Hardy, PhD | Breast | Stearic acid, epidermal growth factor (EGF) | |||
| Role of Wnt Signaling in Butyrate-Induced Colon Carcinoma Cell Proliferation, Differentiation and Apoptosis (2003) | Dr. Sartorelli examined the mechanisms by which butyrate, a natural degradation product of dietary fiber in the colon, can influence the development of colon cancer. | Connecticut | Connecticut | Alan C Sartorelli, PhD | Colon/Rectum | butyrate | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Role of Vitamins in Leukemia Therapy (1987) | Dr. Yen sought to determine how vitamin A or vitamin D can be used to reduce the dosage of certain chemotherapeutic drugs used to treat leukemia and what happens at the level of the cells� genes to make this possible. | New York | New York | Andrew Yen, PhD | Blood/Bone Marrow/Lymph | vitamin D, leukemia | |||
| Role of Vitamins in Leukemia Therapy (1993) | This renewal grant was a continuation of Dr. Yen�s work on how retinoic acid (vitamin A) induces a change in tumor expression in leukemic cells. Overall the goal of this grant was to design a chemotherapeutic regime using retinoic acid, as a prototype, to help treat individuals with leukemia. | New York | New York | Andrew Yen, PhD | Blood/Bone Marrow/Lymph | retinoic acid, leukemia | |||
| Role of Vitamin D in Maturation of Leukemic Cells (1987) | Dr. Studzinski studied how derivatives of vitamin D can prevent the development of leukemia by promoting the transformation of immature, cancer-like cells into normally functioning white blood cells. | New Jersey | New Jersey | George P Studzinski, MD, PhD | Blood/Bone Marrow/Lymph | leukemia | |||
| Role of the Bad Protein in Mediating Tumor Suppressive Effect of Omega-3 PUFAs (2007) | This study examined whether the prostate cancer development by omega-3 polyunsaturated fatty acids is mediated in part through Bad-dependent apoptosis. Bad is a protein that leads to tumour cell death. The role of Bad is not as clear, and it is likely that new mechanistic information of relevance to prostate cancer growth and progression was obtained from these studies. | North Carolina | North Carolina | Yong Chen, PhD | Prostate | omega-3, Bad protein, apoptosis | |||
| Role of the Adrenal Gland in Mediating Cancer Preventive Effects of Caloric Restriction (1999) | Dr. Schwartz attempted to determine the relationship between calorie restriction and the role of the adrenal gland in cancer prevention, specifically through inhibition of enzymes involved in metabolism of sugars. | Pennsylvania | Pennsylvania | Arthur G Schwartz, PhD | Skin | caloric restriction, sugar | |||
| Role of Soy and Red Wine Phytoestrogens in Breast Cancer Progression (2003) | This study used an innovative in situ microscopic imaging system to study the rapid in vivo effects of the phytooestrogens genistein and daidzein from soy, and resveratrol from red wine, on the metastasis of breast cancer cells in laboratory mice. | Puerto Rico | Puerto Rico | Suranganie F Dharmawardhane, PhD | Breast | genistein, soy, daidzein, resveratrol, red wine | Blueberries | ||
| Role of Retinoid Receptors in Mediating the Response to 1,25 (OH)2D3 of Normal and Transformed Keratinocytes (1996) | Dr. Bikle tested whether retinoic acid (RA), selective RA receptor agonists and retinoid X receptor agonists alter proliferation and differentiation, as regulated by 1,25-dihydroxyvitamin D in normal and transformed keratinocytes from epidermis, and the interactions of these components in regulating gene expression. | California | California | Daniel D Bikle, MD, PhD | Skin | retinoic acid, vitamin D, keratinocytes | |||
| Role of Retinoic Acid and Its Receptors in Leukemia Cell Differentiation (1991) | Dr. Sartorelli investigated how retinoic acid might interact with special receptor sites to convert leukemia cells back to normal cells, thereby causing remission in leukemia patients. | Connecticut | Connecticut | Alan C Sartorelli, PhD | Blood/Bone Marrow/Lymph | retinoic acid, leukemia | |||
| Role of Pure Conjugated Linoleic Acid (CLA) Isomers in the Prevention of Cancer (2003) | Dr. Liu examined the anticancer activity of the two major isomers of CLA against adenocarcinoma in mice | New York | New York | Rui Hai Liu, PhD | Stomach | conjugated linoleic acid | |||
| Role of phytic acid in the treatment of cancer (2005) | This study investigated how Ins(1,3,4,5)P4, a metabolite of phytic acid, binds and deactivates Akt signalling pathways to disrupt signals associated with cancer cell survival in ovarian cancer cells. | Massachusetts | Massachusetts | Hongbo R Luo, PhD | Ovary | phytic acid | |||
| Role of p27 and cdk2 in Retinoid Regulation of Breast Cancer Cell Growth (1999) | Dr. Pratt investigated how retinoic acid (RA) inhibits the growth of hormone-dependent breast cancer cells (MCF-7), based on the hypothesis that RA decreases the levels of certain cell kinases and leads to hypophosphorylation of the kinase complexes. | Canada | Canada | M.A. Christine Pratt, PhD | Breast | retinoic acid, cell kinases | |||
| Role of oxGPCs/PAFR in BITC Mediated Suppresion of Melanoma (2009) | Dr. Sahu conducted research that involved a component of cruciferous vegetables and its effect in melanoma. | Indiana | Indiana | Ravi P Sahu, PhD | Skin | cruciferous vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Role of Nutrient Modulation of Cell Adhesion in Colon Cancer (1996) | Dr. Sellin studied the role that cell adhesion molecules have in colon cell differentiation and transformation, as well as the role of dietary calcium, short chain fatty acids and genetic factors in influencing tumor formation in the colon. | Texas | Texas | Joseph H Sellin, MD | Colon/Rectum | calcium, short chain fatty acids, genetic factors | |||
| Role of Niacin as a Chemopreventive Agent in Lung Cancer (2001) | Dr. Chatterjee studied the effects of niacin or nicotinamide deficiency on damage to cellular DNA and how supplementation prevents such damage. | Ohio | Ohio | Satadal Chatterjee, PhD | Lung | niacin, nicotinamide, DNA damage | |||
| Role of MLH1 Promoter, SNP and Diet in Colon Cancer (2007) | This study examined how dietary factors interact with the MLHI-93GA promoter SNP functions and affect the etiology of microsatellite instability positive and negative, microsatellite stable colorectal tumors. Colorectal cancer cases from Ontario, Newfoundland and Seattle were included and cell studies used colorectal cancer cell lines. These studies helped to better understand how dietary factors can regulate the contribution of the MLHI-93GA polymorphism to colorectal cancer susceptibility at the population level. | Canada | Canada | Bharati Bapat, PhD | Colon/Rectum | MLHI-93GA promoter SNP | |||
| Role of Lipotrope in Mammary Tumor and DNA Methylation (1990) | Dr. Park studied the interaction of lipotropes (e.g. choline, methionine, and folic acid) and fat in an attempt to explain how the amounts of each might influence mammary tumor growth. The proper balance of lipotropes and fat in our diets might further reduce cancer risk. | North Dakota | North Dakota | Chung S Park, PhD | Breast | fat | |||
| Role of Green Tea Extracts on Chromatin Remodeling of Telomerase Gene in Cancer Cells (2004) | This postdoctoral study investigated the effects of the green tea catechin, (-)-epigallocatechin-3-gallate (EGCG), on telomerase gene expression in MCF-7 breast cancer cells and human teratocarcinoma cells to determine if the down regulation of this gene is the mechanism by which EGCG induces apoptosis of cancer cells. | Alabama | Alabama | Liang Liu, PhD | Breast | Green tea, EGCG | |||
| Role of Eicosanoids as Promoting Agents in Intestinal Tumorigenesis (1996) | Dr. Whelan investigated whether increased biosynthesis of certain fatty acid derivatives (prostaglandins and leukotrienes) would alter the tumor incidence in mice that already have a propensity to develop intestinal tumors. | Tennessee | Tennessee | Jay Whelan, PhD | Colon/Rectum | prostaglandins, leukotrienes | |||
| Role of Dietary Metals in Breast Cancer (2000) | Dr. Martin�s sought to determine whether the metallic dietary constituents, cadmium and arsenic, have an estrogenic effect in animals, and whether they enhance mammary tumors, either alone or together. | District of Columbia | District of Columbia | Mary Beth Martin, PhD | Breast | cadmium, arsenic | |||
| Role of Dietary Fats and Estrogens in the Etiology of Prostate Cancer: A Rat Model (1997) | Dr. Geliebter investigated whether rats maintained on a diet high in animal fats for two successive generations, and thus putatively exposed to estrogen, would have a higher and earlier incidence of prostatic hyperplasia, both benign and malignant, than in similarly treated rats on corn oil diets. | New York | New York | Jan Geliebter, PhD | Prostate | high-animal fat diet, corn oil diet | Legumes (Dry Beans, Peas & Lentils) | ||
| Role of Dietary Fat-Type on Chemical Carcinogen Activation (1983) | Dr. Wade studied how different types and different amounts of fat in the diet affect the metabolic activation of certain chemicals into carcinogens. Certain fats, like fish oils, seem to have a cancer-inhibiting effect, but it depends on what stage in the cancer process the fish oils are administered. | Georgia | Georgia | Adelbert E Wade, PhD | Other | chemical carcinogens | |||
| Role of Dietary Factors in the Regulation of Nuclear Oncogenes (1993) | Various protooncogenes, precursor cancer genes, play an important role in the normal growth of cells. Activation of these cells to oncogenes is thought to be modulated through nutritional factors such as protein deprivation. Dr. Hann looked at the interrelationship between two proteins, the c-myc 1 and c-myc 2, and how nutritional factors play a role in their transformation. | Tennessee | Tennessee | Stephen R Hann, PhD | Other | protooncogenes, protein deprivation, c-myc 1, c-myc 2 | |||
| Role of Dietary Cholesterol and Fat in the Promotion of Breast Cancer (1990) | Dr. Clarke sought to determine how low-fat, high-fat, and high-cholesterol diets influence the activities of two enzymes, aromatase and sulfatase, which are needed to convert dietary cholesterol to estrogen. This research had the potential to lead to guidelines to help reduce the growth of some types of breast tumors. | District of Columbia | District of Columbia | Robert S Clarke, PhD, DSc | Breast | aromatase, sulfatase, cholesterol | Legumes (Dry Beans, Peas & Lentils) | ||
| Role of Dietary Carotenoids as Anti-Cancer Agents (1994) | Dr. Truscott investigated the efficiency by which various carotenoids quench oxygen radicals and whether the efficiency is dependent on the molecular environment. The major role of carotenoids in cancer prevention is that of quenching oxygen radicals (superoxide and peroxyl radicals). Dr. Truscott aimed to identify the most effective and useful forms of carotenoids for cancer prevention. | United Kingdom | United Kingdom | T.G. Truscott, DSc, FRPC | Other | oxygen radicals | Legumes (Dry Beans, Peas & Lentils), Squash | ||
| Role of Dietary Arginine in Tumor Growth and Metastasis (1997) | Dr. MacLeod looked into the role that dietary arginine and nitric oxide play in the processes of breast tumor metastasis, using a mouse mammary tumor model. | California | California | Carol L MacLeod, PhD | Breast | dietary arginine, nitric oxide | |||
| Role of Dietary Antioxidants in Free Radical Enhancement of Etoposide (VP-16) Antitumor Activity (1994) | Dr. Kagan investigated the interaction between dietary antioxidants, vitamins C and E, BHT and BHA, and etoposide VP-16, a widely used phenolic antitumor drug. He sought to determine how different levels of these antioxidants may affect oxidative activation of VP-16 in K562 human leukemia cells and the extent of cytotoxicity of VP-16 in these cells. | Pennsylvania | Pennsylvania | Valerian E Kagan, PhD, DSc | Blood/Bone Marrow/Lymph | vitamin E, vitacin C, BHT, BHA, etoposide VP-16, leukemia | |||
| Role of Cellular Glutathione in Selenite Cytotoxicity (1991) | Dr. Frenkel investigated whether glutathione, a natural compound composed of amino acids, might increase the ability of dietary selenium to inhibit tumor cell growth. Cancer cells from the lung, breast, and colon were studied. | New Jersey | New Jersey | Gerald D Frenkel, PhD | Breast, Colon/Rectum, Lung | glutathione, selenium | |||
| Role of Arachidonic Acid and PGE2 as Key Mediators of Intestinal Tumorigenesis in Vivo (1999) | Dr. Whelan used a mouse model of intestinal carcinogenesis to delineate the role of the polyunsaturated fatty acid arachidonate and related entities, such as prostaglandin, in the process of tumor formation. | Tennessee | Tennessee | Jay Whelan, PhD | Colon/Rectum | arachidonate, prostaglandins | |||
| Role of Apple in the Prevention of Cancer (2006) | This study tested the preventive effect of apple phytochemicals against mammary cancer in a rat model. | New York | New York | Rui Hai Liu, PhD | Breast | apple, phytochemicals | Apples | ||
| Reversal of Ras Oncogene-Induced Cell Transformation by Dietary Terpenes (1992) | Dr. Ruch investigated how limonene and carvone, components of citrus fruits and caraway seeds, might revert cancerous liver cells back to normal cells. One of the mechanisms that was studied was ras-oncogene activity. | Ohio | Ohio | Randall J Ruch, PhD | Liver | limonene, carvone, citrus fruits, caraway seeds, ras-oncogene | Cherries, Grapefruit | ||
| Reversal of Apoptosis Resistance in Malignant Rat Lymphoma Cells and Human B-Cell Chronic Lymphocytic Leukemia by Butyrate, a Diet-Derived Fatty Acid (1995) | Dr. Buckley used cell culture models to study the molecular processes involved in reversal of tumor progression by butyrate, produced from dietary fiber. Special emphasis was on the examination of whether sodium butyrate alters the H-ras protooncogene signaling pathway. | North Dakota | North Dakota | Arthur R Buckley, PhD | Blood/Bone Marrow/Lymph | sodium butyrate, H-ras protooncogene signaling pathway | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| revention of hepatocellular carcinoma by EGC (2012) | Dr. Fuchs is using an animal model of chronic liver disease to determine whether EGCG (a phytochemical in green tea), inhibits the development of liver cancer by inhibiting cirrhosis. He is testing EGCG alone and in combination with erlotinib, a common treatment for the disease, to determine if it slows tumor progression. | Massachusetts | Massachusetts | Bryan Fuchs, PhD | Liver | ||||
| Retinoids: Mode of Action as Inhibitors of Human Carcinogenesis (1989) | Dr. Bertram studied how retinoic acid, a form of vitamin A, acts to prevent skin cancer. He examined vitamin A-treated human skin to determine if increased communication between cells might inhibit conversion of normal to malignant cells. | Hawaii | Hawaii | John S Bertram, PhD | Skin | retinoic acid | Legumes (Dry Beans, Peas & Lentils) | ||
| Retinoids, Papillomavirus and Cervical Cancer (1993) | Ninety percent of cervical cancers are associated with human papillomavirus (HPV). Vitamin A is known to regulate the function of the epithelial cells of the cervix and HPV cells are sensitive to vitamin A. In his renewal grant, Dr. Eckert sought to identify the gene responsible for retinoid sensitivity in the cells of the cervix in hopes of coming up with better and more effective treatment for this cancer. | Ohio | Ohio | Richard L Eckert, PhD | Cervix | human papillomavirus (HPV) | |||
| Retinoids, Papilloma Virus and Cervical Cancer (1991) | Dr. Eckert investigated the mechanisms by which retinoids might inhibit the human papillomavirus activity associated with cell transformation, and thereby prevent the development and growth of tumors of the cervix. | Ohio | Ohio | Richard L Eckert, PhD | Cervix | human papillomavirus (HPV) | |||
| Retinoids, Insulin-like Growth Factors and Cervical Cancer (1995) | Dr. Eckert examined the regulation of cervical cells by retinoids and aimed to elucidate the mechanisms by which retinoids regulate insulin growth factor binding proteins (IGFBPs). Dr. Eckert hypothesized that retinoids may act as chemopreventive agents by increasing IGFBP-3 levels, which in turn mediate the inhibitory effects of retinoids on cervical cancer cell proliferation. | Ohio | Ohio | Richard L Eckert, PhD | Cervix | insulin growth factor binding proteins, retinoids | |||
| Retinoids and Immune Recovery After Bone Marrow Transplantation (1997) | Dr. High sought to determine whether vitamin A supplementation can improve the immune function of patients receiving bone marrow transplants. | North Carolina | North Carolina | Kevin P High, MD, MSc | Other | bone marrow transplant | |||
| Retinoid Therapy of Neuroblastoma (1997) | Dr. Reynolds studied the mechanisms of action of N-(4-hydroxyphenyl) retinamide (4-HPR) as an inhibitor of the growth of various neuroblastoma cell lines in order to define the types of patients likely to benefit from use of 4-HPR. | California | California | C. Patrick Reynolds, MD, PhD | Nervous System | neuroblastoma, retinoids | |||
| Retinoid Responsiveness of Mammary Carcinoma Cells (1995) | Dr. Talmage examined the cellular events involved in retinoic acid inhibition of cell proliferation in estrogen dependent tumor cell lines and how treatment with interferons leads to inhibitory action in otherwise estrogen independent cell lines. | New York | New York | David A Talmage, PhD | Breast | retinoic acid, estrogen, interferons | |||
| Retinoid Metabolism and Signaling in Oral Cavity Carcinogenesis (2002) | Dr. Tang investigated whether alterations in the metabolism of Vitamin A derivatives might be associated with induction of tumors in the oral cavity of mice. | New York | New York | Xiao-Han Tang, PhD | Head and Neck | metabolism | |||
| Retinoid Interference with Lung Tumor Promotion (1995) | Dr. Malkinson investigated the potential of retinoids to block the lung tumor promoting ability of butylated hydroxytoluene (BHT) metabolite BHTOH, and the effects of BHTOH on gap junction intercellular communication (GJIC), apoptosis and proliferation. In this study retinoid effects will be studied in a model of human adenocarcinoma. | Colorado | Colorado | Alvin M Malkinson, PhD | Lung | BHTOH, retinoids, GJIC | |||
| Retinoid Effects on Growth Factor Gene Expression in Mammary Glands (1989) | Dr. Meeks studied how a special form of vitamin A may be able to interfere with those changes in the genes of breast cells which lead to the development of cancer. | Alabama | Alabama | Robert G Meeks, PhD | Breast | retinoids | |||
| Retinoid Acid-Dependent Regulation of PDGF A Chain Expression (1996) | Dr. Wang investigated the mechanism of the inhibitory action of retinoic acid on the synthesis of a platelet-derived growth factor which serves as a mitogen for a wide range of cell types during differentiation. | Illinois | Illinois | Solita Chiayeng Wang, PhD | Other | retinoic acid | |||
| Retinoic Acid-Dependent Regulation of PDGF A Chain Expression (1994) | Dr. Wang investigated the basic mechanisms by which retinoic acid can regulate gene expression, in particular the expression of the PDGF-A chain. PDGF is a major growth regulator for connective tissues and glial cells. Dr. Wang has shown that PDGF is over-expressed in malignant brain tumors and that retinoic acid blocks PDGF-A protein expression during cell differentiation. She expanded her studies on this activity of retinoic acid and its role as an anti-cancer agent. | Illinois | Illinois | Solita Chiayeng Wang, PhD | Nervous System | retinoic acid. PDGF-A | Legumes (Dry Beans, Peas & Lentils) | ||
| Retinoic Acid Represses Genes on Chromosome 12p: Implications for Testicular Cancer Pathogenesis (2005) | Various genes on chromosome 12p that are repressed by retinoic acid and correlate with retinoic acid-induced loss of tumourigenicity were discovered. This postdoctoral study investigated whether these retinoic acid-repressed genes have oncogenic properties. | New Hampshire | New Hampshire | Caryl J Giuliano, PhD | Testis | retinoic acid, chromosone 12p | |||
| Retinoic Acid - Mediated Tumor Suppression in Human Oral Cancer (1997) | Dr. Wong investigated whether retinoic acid suppresses human oral cancer cell growth because it induced expression of an oral tumor suppresser gene (doc-1) and sought to characterize the specific regions of doc-1 involved in the retinoic acid effect. | Massachusetts | Massachusetts | David Wong, DMSc, DMD | Head and Neck | retinoic acid | |||
| Resveratrol for Ex Vivo Purging of Bone Marrow Transplants (2000) | Dr. Gautam attempted to use resveratrol, a dietary constituent, to selectively purge leukemia cells from bone marrow autografts without damaging the normal hematopoietic progenitor cells in the bone marrow. | Michigan | Michigan | Subhash C Gautam, PhD | Blood/Bone Marrow/Lymph | resveratrol, leukemia | Blueberries | ||
| Response of Beta-Carotene to Dietary Selenium and Alpha-Tocopherol (1990) | Dr. Stoecker sought to determine whether selenium and vitamin E might enhance the conversion of beta-carotene to vitamin A. Independently, selenium, vitamin E, and beta-carotene have been associated with reduced cancer risks. The combination in our diets might further reduce cancer risks. | Oklahoma | Oklahoma | Barbara J Stoecker, PhD | Other | selenium, vitamin E, beta-carotene | Flaxseed, Grapefruit | ||
| Resistance Training and Physical Functioning in Head and Neck Cancer Patients (RETAIN)" (2010) | Dr. Rogers is measuring whether it is feasible and safe to complete tests on muscle strengthening in head and neck cancer patients. The study will also determine the benefits of muscle training (with regard to muscle strength), muscle tissue loss, fatigue, quality of life, and ability to function physically. | Illinois | Illinois | Laura Rogers, MD, MPH | Head and Neck | resistance training, muscle strengthening, cancer patients | |||
| Reliability of Food Composition Data in Epidemiological Diet Cancer Studies (1983) | Studies of the relationships between cancer and diet depend in part on the accuracy of food composition data in order to adequately describe the dietary components. Dr. Young critically examined food composition tables to enable researchers to more accurately report human intake of nutrients. | Massachusetts | Massachusetts | Vernon R Young, PhD | Other | food composition data | |||
| Regulation of Tumors by Endogenous and Exogenous Opioids (1985) | Dr. Hoffman studied how narcotic-like hormones called opioids, found naturally in the human body and also in milk, can influence and possibly regulate the growth of tumors. He investigated which tumors make opioids and how this synthesis is controlled. | California | California | Andrew R Hoffman, MD | Other | opioids, milk | |||
| Regulation of Tumor Progression Gene Expression by Dietary Factors (2000) | Dr. Buckley examined some novel genes found in hormone responsive rat and human tumor cells and investigated whether expression of these genes can be altered by dietary differentiating agents such as butyrate, retinoic acid and vitamin D. | Ohio | Ohio | Arthur R Buckley, PhD | Other | butyrate, retinoic acid | |||
| Regulation of the MYCN Oncogene in Neuroblastoma (2009) | Dr. Wada studied the effect of a form of vitamin A on a series of genes that can cause the childhood cancer called neuroblastoma to become benign. | Hawaii | Hawaii | Randal Wada, MD | Nervous System | retinoic acid, neuroblastoma, MYCN gene | |||
| Regulation of Selenoprotein Translation (2001) | Dr. Diamond used methylated and unmethylated transfer RNA isoacceptors to study formation of selenium-containing proteins in cells and how the process relates to the cancer chemopreventive effects of selenium. | Illinois | Illinois | Alan M Diamond, PhD | Other | selenoprotein, RNA | |||
| Regulation of Selenoprotein Translation (1999) | Dr. Diamond examined the mechanism by which selenium protects against various types of cancer, possibly through the genes that regulate the synthesis of selenoproteins. | Illinois | Illinois | Alan M Diamond, PhD | Other | selenium, selenoproteins | |||
| Regulation of Nucleoside Transport and Drug Toxicity by Polyunsaturated Fatty Acids (1994) | Dr. Meckling-Gill extended her previous studies to include an in vivo tumor model with omega-3 fatty acid supplementation as adjuvant to chemotherapeutic drug treatment to establish whether or not in vitro differences in drug toxicity are replicated in the animal model. | Canada | Canada | Kelly A Meckling-Gill, PhD | Other | omega-3, drug toxicity | |||
| Regulation of Nucleoside Transport and Drug Toxicity by Polyunsaturated Fatty Acids (1992) | Dr. Meckling-Gill sought to determine whether omega-3 or omega-6 polyunsaturated fatty acids (PUFAs) in animal diets or cultured cells affect the uptake of chemotherapeutic nucleoside drugs, such as araC and AZT. | Canada | Canada | Kelly A Meckling-Gill, PhD | Other | omega-3, omega-6, PUFAs, chemotherapeutic nucleoside drugs | |||
| Regulation of Gene Expression by Polyunsaturated Fatty Acids and Retinoids (1995) | Dr. Bernholr used a sensitive assay he developed to study how metabolites of dietary polyunsaturated fatty acids bind to cellular receptors and how in combination with vitamin A derivatives, they regulate genes needed to control cell growth. | Minnesota | Minnesota | David Bernlohr, PhD | Other | polyunsaturated fatty acids, vitamin A | |||
| Regulation of Colonocyte Growth and Differentiation (1994) | Dr. Barnard investigated the mechanism by which butyrate exerts rapid and potent effects on growth and maturation of colon epithelial cells. This effect appears to be mediated through a key growth-regulating gene, c-myc. Dr. Barnard�s studies sought to increase our understanding of the molecular mechanisms by which butyrate affects c-myc as well as the degree of maturation of the colon epithelial cells. | Tennessee | Tennessee | John A Barnard, MD | Colon/Rectum | butyrate, c-myc | |||
| Regulation of C-MYB in Human Myelomonocytic Differentiation (1988) | Dr. Westin examined how vitamin A and vitamin D affect the genes that help to determine whether white blood cells develop into normal cells or whether they develop into the cancer cells of leukemia. | Virginia | Virginia | Eric H Westin, MD | Blood/Bone Marrow/Lymph | leukemia, vitamin A, vitamin D | |||
| Regulation of Apoptosis in Human Colorectal Carcinoma Cells (1998) | Dr. Kumar sought to determine the role of butyrate as an inducer of apoptosis in human colon cancer, especially with reference to Bax and procaspase-3 and proteolytic degradation of DNA repair enzymes. | Texas | Texas | Rakesh Kumar, PhD | Colon/Rectum | butyrate, apoptosis | |||
| Regulation of Apoptosis in Human Colorectal Carcinoma Cells (1996) | The goal of Dr. Kumar�s research was to explore the cellular basis for the protective action of butyrate (produced by fermentation of dietary fiber) against colorectal cancer as well as the involvement of apoptosis or programmed cell death in the protective effect. | Pennsylvania | Pennsylvania | Rakesh Kumar, PhD | Colon/Rectum | butyrate, apoptosis, programmed cell death | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Ras Oncoprotein Processing and Carcinogenesis: Chemoprevention by Retinoic Acid (1993) | The p21 ras-oncogene is thought to transform normal cells to cancerous cells. Dr. Agarwal examined the mechanisms involved and if or how retinoic acid affects the inhibition of a protein which in turn inhibits the p21 ras-oncogene. | Ohio | Ohio | Rajesh Agarwal, PhD | Other | p21 ras-oncogene, retinoic acid | |||
| Protein Metabolism in An Animal Model of Cancer Associated Cachexia: Effects of Ornithine alphaketoglutarate (1992) | Dr. Baracos continued to investigate how ornithine alpha-ketoglutarate (OKG) might improve host protein metabolism and thereby control cachexia and limit the wasting away of muscle tissue in the tumor-bearing host. | Canada | Canada | Vickie E Baracos, PhD | Liver | ornithine alpha-ketoglutarate, malnutrition, weight loss | |||
| Protein Kinase C: Specific Isozymes and Kinase-regulated Genes as Determinants of the Effects of Bile Acids on Normal and Maligant Human Colon Cells (1990) | Dr. Morin sought to determine how bile acids control and possibly prevent the growth of tumors in the large intestine. Fats in our diets are digested to form bile acids. Some bile acids apparently are involved with the conversion of tumor cells back to noncancerous cells. He explored this conversion and the role of the enzyme protein kinase C in the regulation of tumor cell growth. | Illinois | Illinois | Michael J Morin, PhD | Colon/Rectum | bile acids, protein kinase C | |||
| Protective Effect of Dietary Vitamin E Against Drug Induced Cancer (1987) | Dr. Van Eys studied how dietary vitamin E prevents breast cancer from developing in animals treated with the chemotherapeutic drug daunomycin. | Texas | Texas | Jan Van Eys, MD, PhD | Breast | daunomycin | |||
| Protease Inhibitors and Gap Junctions in Breast Cancer Progression and Chemoprevention (1998) | Dr. Sawey sought to determine the relationship between cell-cell interactions as mediated by gap junctions, and the suppression of mammary tumorigenesis in a rodent model by the Bowman-Birk protease inhibitor from soybeans. | Pennsylvania | Pennsylvania | Mary Jean Sawey, PhD | Breast | soy, gap junctions, Bowman-Birk protease inhibitor | |||
| Prostate Cancer Progression in a Transgenic Mouse Model: Dietary Intervention (1999) | Dr. Dodd developed a transgenic mouse model of prostatic cancer, which mimics the human situation of progression from dysplasia to carcinoma, and used the model to determine how dietary genistein inhibits the progression of prostatic cancer. | Canada | Canada | Janice G Dodd, PhD | Prostate | Genistein | |||
| Prostate Cancer Prevention by Phytochemicals in White Button Mushrooms (2005) | The aim of this study was to examine the role of a phytochemical found in white button mushrooms in suppressing the enzymes 5-alpha-reductase and aromatase, which infuence prostate cancer growth. | California | California | Shiuan Chen, PhD | Prostate | white button mushroom, 5-alpha-reductase, aromatase | |||
| Prostate Cancer Prevention by Grape Seed Extract (2000) | Dr. Agarwal assessed the effect of grape seed extract on cell signaling in human prostate cancer cell lines in culture and the action of the extract on growth and regression of human prostate cancer cells implanted in mice. | Colorado | Colorado | Chapla Agarwal, PhD | Prostate | grape seed extract | |||
| Prostate Cancer Chemoprevention (1996) | Dr. Mukhtar investigated the major anticarcinogenic compounds found in green tea (cathechins) for their ability to inhibit carcinogenesis through inhibition of ornithine decarboxylase (ODC) and polyamine levels in a rat prostate model. | Ohio | Ohio | Hasan Mukhtar, PhD | Prostate | green tea cathechins, orinthine decarboxylase | |||
| Prostate Cancer and Green Tea (2000) | Using athymic nude mice implanted with androgen sensitive or androgen insensitive human prostate tumor xenografts as a model, Dr. Mukhtar sought to determine whether (-)-epigallocatechin-3-gallate, from green tea, can inhibit tumor cell growth, induce apoptosis and arrest the tumor cell cycle in the G0-G1 phase of growth. | Ohio | Ohio | Hasan Mukhtar, PhD | Prostate | (-)-epigallocatechin-3-gallate, green tea | |||
| Prostaglandin E Receptors and Intracellular Calcium Signaling in Intestinal Tumorigenesis (2002) | Dr. Whelan tested the hypothesis that a form of prostaglandin is involved in intestinal tumorigenesis through its effects on cellular calcium. | Tennessee | Tennessee | Jay Whelan, PhD | Colon/Rectum | prostaglandins, cellular calcium | |||
| Promotion of Apoptosis by Vitamin D3 and the Vitamin D3 Analog EB 1089 in Irradiated Breast Tumor Cells (1999) | Dr. Gewirtz investigated how vitamin D, or analogs which are less hypercalcemic, can induce apoptosis in breast cancer cells, what cell signaling or regulatory factors are involved, and whether vitamin D compounds can sensitize radioresistant breast cancer cells to radiation treatment. | Virginia | Virginia | David A Gewirtz, PhD | Breast | vitamin D3, apoptosis, radiation treatment | |||
| Prevention of Tamoxifen Resistance by Green Tea Polyphenols (2009) | Dr. Aiyer studied polyphenols found in green tea to determine if they can help prevent the resistance to tamoxifen that many breast cancer patients experience. | District of Columbia | District of Columbia | Harini Aiyer, PhD | Breast | green tea polyphenols, tamoxifen resistance | |||
| Prevention of Skin and Lung Cancer by Ellagic and Tannic Acids: Mechanistic Studies (1986) | Dr. Mukhtar studied how two compounds found in plant foods might prevent the development of skin and lung cancer. | Ohio | Ohio | Hasan Mukhtar, PhD | Lung, Skin | ellagic acid, tannic acid, lung cancer | Blueberries | ||
| Prevention of Prostate Cancer by Garlic Compounds: Novel Nutritional Strategies (2003) | New York | New York | Richard S Rivlin, MD | Other | |||||
| Prevention of Prostate Cancer by Garlic Compounds: Novel Nutritional Strategies (2003) | New York | New York | Richard S Rivlin, MD | Other | |||||
| Prevention of Metastatic Breast Cancer Using a Novel Vitamin E Analog (2007) | Previous studies have found that alpha-tocopheryloxyacetic acid (a-TEA) has the ability to selectively induce apoptosis of cancer cells in vitro and suppress tumour growth in pre-clinical animal models. The goal of this study was to employ Va-TEA, a more water-soluble and versatile version of a-TEA, in combination with an immune cell known as the dendritic cell (DC) to destroy metastatic breast cancer and to establish immunity. | Arizona | Arizona | Emmanuel T Akporiaye, PhD | Breast | alpha-tocopherylixyacetic acid (a-TEA), dendritic cell, metastasis | |||
| Prevention of Malignant Phenotype Generation by Diet-administered Retinoids (1987) | Dr. Taylor investigated whether vitamin A-like compounds could prevent the development of cachexia and the weakening of the immune system in cancer patients, a condition which appears to be caused by their tumors releasing certain metabolic inhibitors into general circulation which are then distributed to healthy tissues. These studies indicated that retinoic acid prevents alterations in fat and protein metabolism, decreases immune functions and cancer, as well as diminishes the growth of tumors and formation of metastases. | Pennsylvania | Pennsylvania | Douglas D Taylor, PhD | Prostate | cachexia, retinoic acid, fat and protein metabolism | Legumes (Dry Beans, Peas & Lentils) | ||
| Prevention of Estradiol-Induced Tumors by Vitamin C (1985) | Dr. Liehr studied in hamsters how vitamin C prevents the development of kidney tumors caused by administration of estrogens. | Texas | Texas | Joachim G Liehr, PhD | Kidney | estrogen | Cranberries | ||
| Prevention of Esophageal Neoplasms by Novel Organosulfur Compounds in Alliums (1992) | Dr. Wargovich investigated how sulfur-containing compounds (s-allylcysteine and diallyl sulfide) from garlic, onions, and related allium vegetables, might inhibit the initiation stage of chemically-induced cancer of the esophagus. | Texas | Texas | Michael J Wargovich, PhD | Esophagus | diallyl sulfide, s-allylcysteine, garlic, onions | Squash | ||
| Prevention of Esophageal Cancer by Novel Organosulfur Compounds in Alliums (1989) | Dr. Wargovich investigated how sulfur-containing compounds (diallyl sulfide and s-allylcysteine) found in garlic, onions and related vegetables inhibit different stages in the development of cancer of the esophagus. | Texas | Texas | Michael J Wargovich, PhD | Esophagus | diallyl sulfide, s-allylcysteine, garlic, onions | Squash | ||
| Prevention of Cancer with Selenium in the PRC (1984) | Dr. Clark investigated the feasibility of using salt fortified with selenium to improve the selenium status of a population at high risk of cancer in the People�s Republic of China. He and his Chinese colleagues conducted a pilot study to demonstrate the safety and feasibility of using a high-selenium brewers yeast in a population of Hepatitis B carriers who were at an extremely high risk of primary liver cancer. | New York | New York | Larry C Clark, PhD | Liver | China, salt, selenium, Hepatitis B | |||
| Prevention of Breast Cancer by Retinoids (1994) | Dr. Ip investigated the mechanisms by which retinoids exert their beneficial effects in cancer prevention and treatment. She sought to determine what effects retinoids have on various nuclear receptors in mammary epithelial cells (MEC). These studies should result in a better understanding of chemopreventive actions of retinoids and result in optimizing the use of dietary retinoids for prevention of breast cancer. | New York | New York | Margot M Ip, PhD | Breast | retinoids, nuclear receptors, mammary epithelial cells | |||
| Prepubertal Soy Diet and Breast Cancer Risk: Role of Estrogen Receptors and Tumor Suppressor Genes (2002) | Dr. Hilakivi-Clark examined the inhibitory effect of either prepubertal dietary soy or of prepubertal estradiol injection on carcinogen-induced mammary cancer in rats and mice, based on the hypothesis that up regulation of estrogen receptor beta and of the tumor suppressor gene BRCA1 are involved in the effect. | District of Columbia | District of Columbia | Leena A Hilakivi-Clarke, PhD | Breast | soy, estradiol, prepuberty, estrogen | |||
| Predictors of Mammographic Breast Density and Validation of Dietary Intake in a Cohort of Mexican Women (2010) | This prospective study among Mexican women is evaluating the associations between mammographic breast density � a predictor of breast cancer � and specific factors, including diet, physical activity, biomarkers of obesity, biomarkers of nutritional status, circulating estradiol, and growth factors. The goal to identify the risk factors of mammographic breast density will allow early preventive measures of breast cancer for Mexican women living in Mexico and in the United States. | France | France | Isabelle Romieu, MD, MPH, ScD | Breast | mammographic breast density, diet, physical activity, nutritional biomarkers, insulin growth factors, Mexican women | |||
| Preclinical Evaluation of the Anti-leukemia Effects of Plant-derived Monoterpenes (2003) | Dr. Clark tested the in vivo anti-leukemia properties of terpenes in a murine model of Bcr/Abl leukemia, and further evaluated in vivo properties of terpenes. | Wisconsin | Wisconsin | Steven S Clark, PhD | Blood/Bone Marrow/Lymph | terpenes, leukemia | |||
| Preclinical Evaluation of the Ability of Monoterpenes to Treat Ph+ Leukemia (1998) | Dr. Clark evaluated the antileukemic action of perillyl alcohol, a hydroxylated monoterpene found in plants, in inducing growth arrest and apoptosis in transformed cells carrying the Philadelphia chromosome, and sought to determine the effects of other monoterpenes on leukemias with the Philadelphia chromosome. | Wisconsin | Wisconsin | Steven S Clark, PhD | Blood/Bone Marrow/Lymph | perillyl alcohol, apoptosis, Philadelphia chromosone, leukemia | Cherries | ||
| Potential Role of Prostaglandins in Tumor-induced Anorexia (1989) | Dr. McCarthy explored the possibility that the loss of appetite and drop in body weight frequently experienced by cancer patients may be caused by a group of substances called prostaglandins in the body. | Wisconsin | Wisconsin | Donna O McCarthy-Beckett, PhD | Other | prostaglandins | |||
| Plasma Free Omega-6 and Omega-3 Polyunsaturated Fatty Acids and the Regulation of Tumor Growth In Vivo (1990) | Dr. Sauer investigated how the growth of tumors is regulated by two types of polyunsaturated fatty acids (PUFAs). He studied how omega-6 PUFAs (in corn and safflower oils) increase liver tumor development and how omega-3 PUFAs (in fish and linseed oils) inhibit liver tumor development. | New York | New York | Leonard A Sauer, MD, PhD | Liver | omega-3, omega-6 polyunsaturated fatty acids, corn and safflower oil, fish and linseed oil | |||
| Plant Anti-oxidant Combinations in Leukemia: A Cell-based Model for Cancer Prevention (2010) | This cell study is investigating if combinations of the plant antioxidants curcumin, carnosic acid, and silibinin have the potential for preventing acute myeloid leukemia, and seeks to determine the mechanism of the concerted anti-leukemic action of these combinations. | New Jersey | New Jersey | United States | George 0 Studzinski, M.D., Ph.D. | Blood/Bone Marrow/Lymph | leukemia prevention, curcumin, botanical antioxidants, DNA damage, cell cycle inhibitors | ||
| Plant Anti-oxidant Combinations in Leukemia: A Cell-based Model for Cancer Prevention (2010) | This cell study is investigating if combinations of the plant antioxidants curcumin, carnosic acid, and silibinin have the potential for preventing acute myeloid leukemia, and seeks to determine the mechanism of the concerted anti-leukemic action of these combinations. | New Jersey | New Jersey | George Studzinski, MD, PhD | Blood/Bone Marrow/Lymph | leukemia prevention, curcumin, botanical antioxidants, DNA damage, cell cycle inhibitors | |||
| Plant Anti-oxidant Combinations in Leukemia: A Cell-based Model for Cancer Prevention (2010) | This cell study is investigating if combinations of the plant antioxidants curcumin, carnosic acid, and silibinin have the potential for preventing acute myeloid leukemia, and seeks to determine the mechanism of the concerted anti-leukemic action of these combinations. | New Jersey | New Jersey | George Studzinski, MD, PhD | Blood/Bone Marrow/Lymph | leukemia prevention, curcumin, botanical antioxidants, DNA damage, cell cycle inhibitors | |||
| Plant Anti-oxidant Combinations in Leukemia: A Cell-based Model for Cancer Prevention (2010) | This cell study is investigating if combinations of the plant antioxidants curcumin, carnosic acid, and silibinin have the potential for preventing acute myeloid leukemia, and seeks to determine the mechanism of the concerted anti-leukemic action of these combinations. | New Jersey | New Jersey | George Studzinski, MD, PhD | Blood/Bone Marrow/Lymph | leukemia prevention, curcumin, botanical antioxidants, DNA damage, cell cycle inhibitors | |||
| Phytoestrogen-induced Nongenomic Signaling and its Functional Consequences in Pituitary Cancer (2006) | This study determined how phytoestrogens act on nongenomic pathways to activate MAP kinases, alter calcium levels and release prolactin to inhibit the development of pituitary tumors in rats. | Texas | Texas | Cheryl S Watson, PhD | Nervous System | phytoestrogen, MAP kinase, calcium, prolactin, pituitary tumors | |||
| Phytate Promotes Apoptosis in Coloncytes via Inhibition of the PI 3 Kinase/Akt Signaling Pathway (1998) | Dr. Turner studied whether phytate, a component of high fiber diets, decreases colon cancer in animal models by enhancing programmed cell death through inhibition of certain enzymes involved in the process of carcinogenesis. | Texas | Texas | Nancy D Turner, PhD, CNS | Colon/Rectum | phytate, PI 3 kinase/Akt signaling pathway, apoptosis | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Pharmocodynamic Effects of Perillyl Alcohol in Humans (1997) | Dr. Hohl examined the role of perillyl alcohol, a metabolite of limonene, in decreasing the expression of Ras protein in patients in a clinical trial, presumably through inhibition of farnesyl- and geranylgeranyl protein transferases. | Iowa | Iowa | Raymond J Hohl, MD, PhD | Other | perillyl alcohol, limonene, Ras protein, clinical trial | Cherries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Grapefruit | ||
| Paddlefish as Anticarcinogenic Food (1989) | Dr. Wong sought to determine whether the large freshwater paddlefish contains certain fats which can slow down or prevent the growth of tumors and whether certain substances in its cartilage can deprive tumors of their blood supply. | Kentucky | Kentucky | John L Wong, PhD | Other | paddlefish | |||
| Oxidative DNA Damage and Breast Cancer Risk (1991) | Dr. Djuric studied how fat can be converted in the body to products that can damage DNA and how this damage to DNA might be used to diagnose breast cancer or detect people at increased risk for developing breast cancer. | Michigan | Michigan | Zora Djuric, PhD | Breast | fat, DNA damage | |||
| ody Size at Young Ages and Novel Biomarkers of Breast Cancer Ris (2012) | Dr. Baer is looking at data from girls to see whether body fatness in childhood and adolescence has effects on breast density or on levels of an ovarian hormone called MIS (Mullerian inhibiting substance) later in life, during young adulthood. | Massachusetts | Massachusetts | Heather Baer, SD | Breast | ||||
| Obesity-Related Risk Factors in Prostate Cancer (1986) | Dr. Neugut explored how obesity, diet, and hormone levels affect the risk of developing prostate cancer for Caucasian, African-American, and Hispanic men in New York City. | New York | New York | Alfred I Neugut, MD, PhD | Prostate | obesity, hormone levels, Caucasians, African-Americans, Hispanics | |||
| Obesity-induced IGF-1 Coordinately Upregulates COX-2 and Downregulates Tumor Suppressive PGDH Resulting in Enhanced Pancreatic Cancer Growth (2010) | This study is examining the hypothesis that the increased levels of insulin-like growth factor (IGF-1) caused by obesity alter the levels of several hormones and growth factors. The substances then lead to chronic inflammation, which may contribute to pancreatic cancer development. The study will treat specialized pancreatic cancer cells with IGF-1 and examine the levels of several substances in the pancreas of lean, overweight and obese mice and in mice that lack circulating IGF-1. | Texas | Texas | Susan Fischer, PhD | Pancreas | Obesity, pancreatic cancer, inflammation, COX-2, PGDH, prostaglandin, IGF-1 | |||
| Obesity-induced IGF-1 Coordinately Upregulates COX-2 and Downregulates Tumor Suppressive PGDH Resulting in Enhanced Pancreatic Cancer Growth (2010) | This study is examining the hypothesis that the increased levels of insulin-like growth factor (IGF-1) caused by obesity alter the levels of several hormones and growth factors. The substances then lead to chronic inflammation, which may contribute to pancreatic cancer development. The study will treat specialized pancreatic cancer cells with IGF-1 and examine the levels of several substances in the pancreas of lean, overweight and obese mice and in mice that lack circulating IGF-1. | Texas | Texas | United States | Susan 0 Fischer, Ph.D. | Pancreas | Obesity, pancreatic cancer, inflammation, COX-2, PGDH, prostaglandin, IGF-1 | ||
| Obesity-induced IGF-1 Coordinately Upregulates COX-2 and Downregulates Tumor Suppressive PGDH Resulting in Enhanced Pancreatic Cancer Growth (2010) | This study is examining the hypothesis that the increased levels of insulin-like growth factor (IGF-1) caused by obesity alter the levels of several hormones and growth factors. The substances then lead to chronic inflammation, which may contribute to pancreatic cancer development. The study will treat specialized pancreatic cancer cells with IGF-1 and examine the levels of several substances in the pancreas of lean, overweight and obese mice and in mice that lack circulating IGF-1. | Texas | Texas | Susan Fischer, PhD | Pancreas | Obesity, pancreatic cancer, inflammation, COX-2, PGDH, prostaglandin, IGF-1 | |||
| Obesity-induced IGF-1 Coordinately Upregulates COX-2 and Downregulates Tumor Suppressive PGDH Resulting in Enhanced Pancreatic Cancer Growth (2010) | This study is examining the hypothesis that the increased levels of insulin-like growth factor (IGF-1) caused by obesity alter the levels of several hormones and growth factors. The substances then lead to chronic inflammation, which may contribute to pancreatic cancer development. The study will treat specialized pancreatic cancer cells with IGF-1 and examine the levels of several substances in the pancreas of lean, overweight and obese mice and in mice that lack circulating IGF-1. | Texas | Texas | Susan Fischer, PhD | Pancreas | Obesity, pancreatic cancer, inflammation, COX-2, PGDH, prostaglandin, IGF-1 | |||
| Obesity, Energy Balance and Breast Cancer: the Role of Insulin-like Growth Factor-1 (2008) | This study examined the role of the IGF-1/Akt/mTOR pathway in breast cancer by following the impact of changes in dietary energy balance on tumor development and metastases, and investigated whether pharmacologically-induced alterations of this pathway reduce obesity-induced mammary tumorigenesis. | Texas | Texas | Stephen D Hursting, PhD, MPH | Breast | obesity, dietary energy balance, metastases | |||
| Nutritional Support in the Chemotherapy of Young Breast Cancer Patients (1983) | Dr. Wilmore studied, in young breast cancer patients undergoing intensive chemotherapy and bone marrow infusions, how intravenous nutritional feeding affects the functioning of the kidneys, lungs, heart, blood system, liver, and gastrointestinal tract, in the hope that specific nutritional benefits could be identified and pursued. | Massachusetts | Massachusetts | Douglas W Wilmore, MD | Breast | chemotherapy, intravenous nutritional feeding | |||
| Nutritional Probing of Cachectic Factors, Metabolic Alterations, and Enhanced Energy Expenditure in Lung Cancer (1986) | Dr. DiGirolamo explored the possibility that cancer cachexia may result from the excessive breakdown of fat stores throughout the body, caused by hormones or other substances released by the tumor. | Georgia | Georgia | Mario DiGirolamo, MD | Lung | fat, hormones | |||
| Nutritional Probing of Cachectic Factors and of Metabolic and Bio-energetic Alterations in Lung Cancer (1988) | Dr. DiGirolamo explored metabolic derangements underlying cancer cachexia in lung cancer patients. The possible mechanisms by which hormones and other substances released by the tumor or the host might induce the metabolic changes and lead to excessive weight loss were studied. | Georgia | Georgia | Mario DiGirolamo, MD | Lung | hormones, metabolic changes | |||
| Nutritional Modulation of Cancer Progression (1985) | Dr. Meadows, followed up his previous research results that restricting the amount of two amino acids in the diet can reduce the spread of cancer cells throughout the body, by trying to determine whether it is a deficiency of those amino acids or a loss in body weight that is affecting the cancer and if the effect persists throughout the treatment. | Washington | Washington | Gary G Meadows, PhD | Skin | amino acid deficiency, weight loss | |||
| Nutritional Modulation of Apoptosis and Chemosensitivity: A Novel Anticancer Strategy (1996) | Dr. James utilized caloric restriction in combination with low doses of etoposide (chemotherapeutic drug) followed by feeding as an experimental anticancer strategy to increase the sensitivity of mammary tumors to apoptosis and thus provide nutritional/ chemotherapeutic regimen to achieve higher levels of cancer cell killing in a rat model of chemically induced mammary cancer. | Arkansas | Arkansas | S. Jill James, PhD | Breast | etoposide, caloric restriction | |||
| Nutritional Determinants of Breast Cancer (1993) | Dr. Romieu studied the association between increased consumption of alcohol and fat, through meat and dairy products, with the increased risk for breast cancer in Mexican women. She also examined the effects of a high consumption of vitamins A, C, and E decreasing breast cancer risk. Dr. Romieu sought to identify avoidable risk factors and determine protective effects of various foods and nutrients. | Mexico | Mexico | Isabelle Romieu, MD, MPH, ScD | Breast | high-fat diet, high-alcohol diet, vitamin C, vitamin E | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Grapefruit, Squash | ||
| Nutritional Determinants of Breast Cancer (1990) | Dr. Romieu sought to identify in patients the components of their diets that appear to be responsible for the occurrence of their breast cancer. She looked specifically for possible correlations between the dietary intake of high fat and high alcohol and increased risk for breast cancer as well as the dietary intake of high vitamin A, C, or E and reduced risk for breast cancer. | Mexico | Mexico | Isabelle Romieu, MD, MPH, ScD | Breast | high-fat diet, high-alcohol diet, vitamin C, vitamin E | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Grapefruit, Squash | ||
| Nutritional Antioxidants in Radiation-Induced Lung Injury (2003) | This proposal determined whether oxidative tissue damage is central in lung injury during radiation and whether treatment with dietary antioxidants and food supplements that augment endogenous antioxidant enzymes inhibits or ameliorates short-term and/or long-term normal tissue damage in the lung. | Pennsylvania | Pennsylvania | Melpo Christofidou-Solomidou, PhD | Other | food supplements, oxidative tissue damage | |||
| Nutrition, Fatty Acids, Antioxidants, Genotoxicity and Cancer (1995) | Dr. Box examined how damage, caused by oxidized dietary fatty acids, to the genetic material of the cell plays a role in the processes leading to cancer, and how tocopherol (vitamin E) can prevent this damage. | New York | New York | Harold C Box, PhD | Other | fatty acids, tocopherol | |||
| Nutrition and Breast Cancer in Iceland (1983) | Dr. Day examined health records in Iceland, some dating back to 1910, to determine how changes in body weight, body fat and other physical and biochemical characteristics are related to the risk of developing breast cancer. | France | France | Nicholas E Day, PhD | Breast | Iceland, body fat | |||
| Nuclear Retinoid Receptors Are Effective Tumor Suppressor Genes (1993) | On the basis of new evidence that genes have receptors for retinoic acid (vitamin A) and that these receptors appear to regulate translation of various cell growth codes, Dr. Peacocke has demonstrated that retinoic acid receptor beta (RAR?), a specific receptor, plays a role in suppressing tumor growth. She sought to confirm her hypothesis that vitamin A, and specifically RAR?, may prevent and treat certain cancers by suppressing tumor genes. | Massachusetts | Massachusetts | Monica Peacocke, MD | Skin | retinoic acid receptor beta | |||
| Non-invasive Detection of Colonic Cellular Markers: Modulation by Diet and Carcinogen (1993) | In a previously funded AICR study, the investigator found a positive correlation between membrane protein kinase C and cell proliferation. In this study Dr. Lupton investigated the prognostic value of cell proliferation and protein kinase C in tumors. She sought to determine if intermediate markers, isolated cells from fecal material, can predict the neoplastic process. The markers tested included: protein kinase C, indicating malignant transformation, and p53 oncogene, which appears to regulate entry into and progression through the cell. | Texas | Texas | Joanne R Lupton, PhD | Colon/Rectum | protein kinase C | Legumes (Dry Beans, Peas & Lentils) | ||
| Neuropeptide Y and Cancer Anorexia (1991) | Dr. Chance investigated whether injections of neuropeptide Y (NPY), might increase the appetite of patients that experience cancer anorexia, loss of appetite. NPY is a unique protein that stimulates appetite and that is at low levels in the blood and brain of animals with tumors. | Ohio | Ohio | William T Chance, PhD | Other | neuropeptide Y | |||
| Neural Cell Adhesion Molecule and Retinoic Acid Receptor Expression in Brain Tumors: Their Potential Roles in Metastasis and Adoptive Immunotherapy (1993) | Neural cell adhesion molecule (NCAM) expression may be regulated by retinoic acid causing increased intercellular adhesion and a decreased ability for tumors to infiltrate the brain thereby decreasing potential metastatic tumors. Dr. Kruse examined the potential role of NCAMs in immunotherapy for astrocytomas and glioblastomas, two types of brain tumors. | Colorado | Colorado | Carol A Kruse, PhD | Nervous System | NCAM expression, retinoic acid | |||
| N-Nitroso Compounds and Alkylating Agents from Nitrosated Amino Acids, Gastric Juice and Foods (1994) | Dr. Mirvish sought to elucidate whether nitrosation of free amino acids in the stomach results in products that are capable of binding DNA. Potentially, these adducts initiate carcinogenesis and may result in gastric cancer. Animal and human studies were carried out to determine if nitroso compounds in the gastric juice are a result of feeding nitrates. Selected foods, including hot dogs and salted dried fish, were analyzed for compounds that could yield carcinogenic nitroso compounds. | Nebraska | Nebraska | Sidney S Mirvish, PhD | Stomach | nitrosation, hot dogs, salted dried fish | |||
| MYB in Retinoic Acid and Vitamin D3 Induced Hemapoietic Differentiation (1995) | Based on his earlier work, Dr. Westin studied how derivatives of vitamins A and D can modulate the growth of normal white blood and human leukemic cells in culture and lead to ordered differentiation, mediated by changes in the c-myb gene. | Virginia | Virginia | Eric H Westin, MD | Blood/Bone Marrow/Lymph | leukemia, vitamin A, vitamin D | |||
| Mutators and Folate Deficiency in Colon Cancer (1996) | In order to provide nutritional guidelines for people with a genetic predisposition to colon cancer, Dr. Sedwick investigated the effects of folate deficiency on cell cytotoxicity in colon tumor cell lines. | Ohio | Ohio | W. David Sedwick, PhD | Colon/Rectum | folate deficiency, cell cytotoxicity | Legumes (Dry Beans, Peas & Lentils) | ||
| Multiple Factor Analysis of Dietary and Socioeconomic Factors and Cancer (1994) | Dr. Campbell used a collection of data gathered over a ten year period in China covering 85 survey counties to analyze past and present dietary practices, biochemical indices and socioeconomic status and their relationship to chronic diseases and particularly to cancer. | New York | New York | T. Colin Campbell, PhD | Breast, Colon/Rectum, Esophagus, Liver, Lung, Nasopharynx, Stomach | China, dietary practices, biochemical indices, socioeconomic status, chronic disease | |||
| Mucin Depleted Foci (MDF) as New Biomarkers in Colon Carcinogenesis (2005) | This study examined mucin depleted foci (MDF) in the colonic mucosa of carcinogen (AOM) treated rats and determined whether MDF are direct precursors of colon tumors. | Italy | Italy | Giovanna Caderni, DSc | Colon/Rectum | mucin depleted foci | |||
| Molecular Mechanisms of Human CYP1A Gene Regulation by Bioflavonoids (1999) | Dr. Quattrochi studied the mechanism by which extracts of green tea inhibit the induction of oxidizing enzymes, namely CYP1A1 and CYP1A2, by the environmental contaminant dioxin. | Colorado | Colorado | Linda C Quattrochi, PhD | Other | green tea, CYP1A1, CYP1A2, dioxin | Legumes (Dry Beans, Peas & Lentils) | ||
| Molecular Mechanisms Involved in the Suppressive Effects of Garlic Derivatives on Cell Growth and Motility in Prostate Cancer Cells (2005) | This study focused on two derivatives of garlic, S-allylcysteine and S-allylmercaptocysteine, that are thought to suppress the motility and decrease survival of prostate cancer cells, mediated through Rho-CTPase and E-cadherin pathways. | China | China | Xianghong Wang, PhD | Prostate | garlic, s-allylcysteine, s-allylmercaptocysteine | |||
| Molecular Analysis of Indole-3-carbinol (I3C) Signaling Events in Prostate Cancer Cells (2000) | Dr. Chinni investigated the molecular mechanisms by which indole-3-carbinol from cruciferous vegetables can suppress the growth of prostate cancer cells in culture and eventually eliminate the tumor cells. | Michigan | Michigan | Sreenivasa Chinni, PhD | Prostate | indole-3-carbinol, cruciferous vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Modulation of Protein Kinase C Isozymes During Vitamin D Mediated Apoptosis of Breast Cancer Cells (1995) | Dr. Narvaez sought to examine the role of protein kinase C isozymes in vitamin D induced apoptosis in breast cancer cells. This postdoctoral study may provide insight into the mechanisms of vitamin D in breast cancer and may lead to novel combination therapies with increased efficacy for breast cancer treatment. | New York | New York | Carmen J Narvaez, PhD | Breast | protein kinase C | |||
| Modulation of Protein Kinase C by Lipids (1993) | Dr. Locniskar continued studying linoleic acid, an omega-6 polyunsaturated fatty acid, and the role it seems to play in protein kinase C activation and distribution, that is essential for normal cell communication. She has shown that diets high in linoleic acid have decreased chemically-induced skin carcinogenesis when fed in the promotion stage. | Texas | Texas | Mary F Locniskar, PhD | Skin | linoleic acide, omega-6, protein kinase C | |||
| Modulation of Peroxisome Proliferation and Hepatocarcinogenesis by Dietary Conjugated Linoleate (1996) | Dr. Belury examined the mechanism by which conjugated linoleic acid (CLA), present in certain dietary components, particularly cooked meats and cheeses, can have a preventive action against chemical carcinogenesis. | Indiana | Indiana | Martha A Belury, PhD | Liver | conjugated dienoic linoleate (CLA), meat, cheese | |||
| Modulation of Oxidative DNA in Rats by Diet (1993) | Dr. Djuric examined the effects of caloric restriction and fat intake on the DNA of cells. Animals were fed differing levels of fat calories and their DNA damage to both the tissue and the blood was analyzed to correlate changes in the mammary gland and future risk of breast cancer. This was a collaborative study supported by AICR and the Food and Drug Administration�s National Center for Toxicological Research. | Michigan | Michigan | Zora Djuric, PhD | Breast | Caloric restriction, fat, DNA damage | |||
| Modulation of Metastasis by Dietary Fat (1987) | Dr. Boylan investigated how the amount and type of fat in the diet affects the spread of breast cancer to the lungs. | New York | New York | Elizabeth S Boylan, PhD | Breast | metastasis, lungs | |||
| Modulation of Fatty Acylation of Src Family Kinases by Dietary Fat (2000) | Dr. Resh studied whether certain oncoproteins, the SRC-related kinases, can be acylated by other fatty acids besides palmitate, and whether dietary intake of specific fatty acids modifies the pattern of acylation and of possible malignant transformation. | New York | New York | Marilyn D Resh, PhD | Breast | oncoproteins, acylation, Src kinases | Legumes (Dry Beans, Peas & Lentils) | ||
| Modulation of Fatty Acylation of Src Family Kinases by Dietarty Fat (2002) | Dr. Resh investigated how different types of fatty acids perform in the N- and S-acylation of kinases of the Src family, which are involved in cell transformation. Acylation leads to binding to cell membranes, thus facilitating the capability of the Src kinases to lead to cancer. | New York | New York | Marilyn D Resh, PhD | Breast | acylation, Src kinases | |||
| Modulation of Estrogen Metabolism in Human Mammary Cells by Dietary Chemicals (2001) | Dr. Zhu�s studied the ability of chemopreventive dietary constituents to modulate estrogen metabolism through alteration of Phase I and Phase II enzymes leading to 2-OH and 4-OH derivatives of estrogen. | South Carolina | South Carolina | Bao Ting Zhu, PhD | Breast | estrogen metabolism, enzymes, 2-OH, 4-OH | |||
| Modulation of Colon Cancer Phenotype by Short Chain Fatty Acids (1994) | Dr. Basson studied the effect of butyrate and other short chain fatty acids that are produced by bacteria from dietary fiber on the growth and differentiation of human colon cancer cells. Dr. Basson will demonstrate whether butyrate alone will interfere with malignant transformation and whether it is selectively more potent than other short chain fatty acids in protecting against colon cancer. | Connecticut | Connecticut | Marc D Basson, MD, PhD | Colon/Rectum | butyrate, short chain fatty acids | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Modulation of Carcinogenesis by Dietary Fats and Antioxidants (1983) | Dr. Carubelli studied how the presence of different and varying levels of fat in the diet, together with the antioxidant food additive BHT, can alter the functioning of certain enzymes which surround the nucleus of liver cells and which may be important for the inactivation of carcinogens. | Oklahoma | Oklahoma | Raoul Carubelli, PhD | Liver | BHT, carcinogens | |||
| Modulation of Anticarcinogenic Activities of Vegetables by Thermal Processing (1994) | Dr. Talalay investigated the effects of common cooking methods on potent detoxification enzyme inducers, such as sulforaphane, in various cruciferous vegetables. These enzymes in turn play an important role in detoxifying chemical carcinogens and blocking tumor formation. Dr. Talalay sought to determine the potencies of vegetable extracts for their induction capabilities and the effect of various methods of heating on their potency. | Maryland | Maryland | Paul Talalay, PhD | Other | sulforaphane, cooking methods | Broccoli & Cruciferous Vegetables, Squash | ||
| Modulation by Dietary Fat of Human Breast Carcinoma Growth: A Phenomenon of Altered Cell Proliferation or Altered Cell Loss? (1990) | Dr. Welsch sought to determine whether the varied effects on tumor growth caused by different amounts and types of fats (from corn oil, beef tallow, or fish oil) in the diet are due to changes in the rate of cell division or the rate of cell death. | Michigan | Michigan | Clifford W Welsch, PhD | Breast | corn oil, beef tallow, fish oil | |||
| Modification of Tumor Initiation by High Fat Diets (1990) | Dr. Lawson investigated the mechanisms by which high dietary fat might be involved with the initiation of tumors. He studied how low-and high-fat diets alter enzymes that convert nitrosamines to agents that cause cancer in the pancreas. | Nebraska | Nebraska | Terence A Lawson, PhD | Pancreas | low-fat diet, high-fat diet, enzymes, nitrosamines | |||
| Modification of Mutagen Sensitivity by Dietary and Chemopreventive Factors in Head and Neck Cancer in Vitro (1991) | Dr. Trizna sought to determine if dietary factors including vitamins A, C, and E, selenium, or cysteine, might prevent damage to DNA, the genetic material, and thereby lower the inherited tendency for developing cancers of the head and the neck. | Texas | Texas | Zoltan Trizna, MD | Head and Neck | vitamin A, vitamin C, vitamin E, selenium, cysteine, DNA damage | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Grapefruit, Squash | ||
| Mode of Action of Dietary Fat in UV-Carcinogenesis (1996) | Dr. Black continued his investigations on the role of various types and levels of dietary lipids on the immune system of mice with ultraviolet (UV)-induced skin cancer in an attempt to develop immunopreventive therapies against these cancers. | Texas | Texas | Homer S Black, PhD | Skin | dietary lipids, UV radiation | |||
| Mixtures of Foods with Enhanced Cancer Prevention Activity (2007) | Based on tissue engineering of skin, a collagen-fibroblast-endothelial cell pseudo-mesenchyme with an epithelial cell surface was created. The goal of this study was to establish and validate an engineered �pseudo-tissue� culture system to more accurately and effciently test optimal dosage combinations of dietary chemo-prevention agents. | Ohio | Ohio | John F Lechner, PhD | Skin | pseudo-tissue | |||
| Methyl-Groups, Diacylglycerol and Hepatocarcinoma (1992) | Dr. Zeisel sought to elucidate the role of protein kinase C in carcinogenesis in rats fed diets deficient in choline, a source of methyl groups. This causes accumulation of diacylglycerol in the liver and increased susceptibility to liver cancer. | North Carolina | North Carolina | Steven H Zeisel, MD, PhD | Liver | choline deficiency, 1,2-sn-diacylglycerol, protein kinase C | |||
| Metabolism of Methyl Groups and Cancer (1986) | Diets deficient in methyl groups have been shown to be carcinogenic. Dr. Wagner studied if the activity of an enzyme in the liver is altered when the animals are fed methyl-deficient diets and, if so, is it related to the process of liver cancer. | Tennessee | Tennessee | Conrad Wagner, PhD | Liver | methyl groups, methyl deficiency | |||
| Metabolism and Pharmacokinetics of IP6 In Vivo (1998) | Dr. Vucenik performed detailed pharmacokinetic studies of orally and intravenously administered inositol hexaphosphate (IP6) in both normal and tumor bearing mice, in order to introduce this chemopreventive agent from dietary fiber into clinical trials. | Maryland | Maryland | Ivana Vucenik, PhD | Multiple Sites | phytic acid | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Metabolic, Dietary and Environmental Factors in Head and Neck Cancer (1993) | Dr. Trizna studied the ability of the body to metabolize carcinogens, both ingested and inhaled, and their effects on the tumors and surrounding tissues of the head and neck. He investigated the effects of dietary intake of antioxidants on metabolism in the head and neck by examining various markers including the relative activity rates of several detoxifying enzymes and levels of blood lymphocytes in this area of the body. | Texas | Texas | Zoltan Trizna, MD | Head and Neck | metabolism, detoxifying enzymes, lymphocytes | Legumes (Dry Beans, Peas & Lentils) | ||
| Metabolic Profiling of Plants for Health (2008) | This study proposed that metabolic profling of phytochemicals may be useful for assessment of how fruits and vegetables are benefcial to overall health and disease prevention. The rationale is that if particular compounds found in the metabolic fingerprint of dry bean are not found in plasma, the probability that they are related to health benefits is reduced. The goal of the work was to determine what chemicals in dry beans account for the differential anticancer effects seen in experimentally-induced breast cancer. | Colorado | Colorado | Meghan M Mensack, PhD | Breast | phytochemicals, dry beans, plasma | Squash, Cherries | ||
| Metabolic Processes Behind Cancer Cachexia: Is Insulin Resistance A Factor? (1992) | Dr. Tayek sought to determine whether the increase in growth hormone levels observed in head and neck cancer patients might be responsible for their increased glucose levels, increased insulin resistance, and altered glucose metabolism, in an effort to improve the nutritional status of these patients. | California | California | John A Tayek, MD | Head and Neck | glucose, insulin | |||
| Metabolic Processes Behind Cancer Cachexia: Is Insulin Resistance a Factor? (1989) | Dr. Tayek investigated how glucose metabolism and insulin response are changed in patients with head and neck cancer so that diets can be designed to improve the nutritional state and prevent excessive weight loss in these cancer patients. | California | California | John A Tayek, MD | Head and Neck | glucose, insulin | |||
| Metabolic Inflexibility: a Potential Link between Obesity and Postmenopausal Breast Cancer (2009) | Dr. Giles studied how weight gain that coincides with menopause increases risk for postmenopausal breast cancer. | Colorado | Colorado | Erin Giles, PhD | Breast | Obesity, postmenopausal breast cancer, energy metabolism | |||
| Metabolic Alterations in Patients with Oropharyngeal Cancer (1988) | Dr. Klein studied whether the excessive loss of weight experienced by many cancer patients may be due to an abnormality in metabolism which wastes the energy from food instead of using it to build and repair body tissues. | Texas | Texas | Samuel Klein, MD | Head and Neck | metabolism, energy | |||
| Mechanistic Examination of Walnuts in Prevention of Breast Cancer (2007) | Dr. Vanden Heuvel studied if walnut extract decreases the risk of breast cancer by affecting the function of tumor cells and fat cells and by modulating how they communicate with each other. This cell-cell communication between adipocytes and cancer cells is potentially a key step by which diet can modulate the cancer process. | Pennsylvania | Pennsylvania | John P Vanden Heuvel, PhD | Breast | Walnuts | |||
| Mechanisms Underlying Induction of Apoptosis During Tyrosine and Phenylalanine Deficiency (2001) | Dr. Meadows studied the mechanisms by which restriction of two dietary amino acids blocked the growth of melanoma cells, affected other cellular functions, and eventually led to death of the melanoma cells. | Washington | Washington | Gary G Meadows, PhD | Skin | amino acid deficiency, tyrosine, phenylalanine | |||
| Mechanisms of Retinoid Regulation of Anti-Apoptotic Proteins Survivin and Bcl-2 (2004) | These investigations focused on the mechanisms by which the vitamin A derivative, retinoic acid, inhibits the expression of two anti-apoptotic proteins in human estrogen-dependent breast cancer cell lines and thereby promotes apoptosis of the cells. It also examined whether downregulation of expression of the respective genes by retinoic acid improves the cytotoxicity of several chemotherapeutic agents. | Canada | Canada | M.A. Christine Pratt, PhD | Breast | retinoic acid, Bcl-2 gene, estrogen, apoptosis | |||
| Mechanisms of Resveratrol-induced Apoptosis and Its Role in Chemoprevention of Cancer (1999) | Dr. Dong studied whether resveratrol, a cancer chemopreventive agent present in grapes and peanuts, induces apoptosis in tumor cells through a p53-dependent pathway or through a route dependent on activation of certain protein kinases. | Minnesota | Minnesota | Zigang Dong, PhD, MD | Other | resveratrol, apoptosis | Blueberries | ||
| Mechanisms of Regulation of Breast Cancer Cell Growth by Nuclear Vitamin A Receptors (1993) | Retinoids have been shown to inhibit transcription of an estrogen-responsive gene in breast cancer cells. Dr. Pratt examined the mechanisms by which this process occurs. | Canada | Canada | M.A. Christine Pratt, PhD | Breast | estrogen | |||
| Mechanisms of Lung Tumor Prophylaxis by BHT (1986) | Dr. Malkinson studied why BHT, an antioxidant used as a food additive, stimulates lung cancer in one strain of mice but inhibits lung cancer in another strain. The strain of mice in which BHT protects against lung cancer also appears to be the only strain in which a low activity of an enzyme (called Protein Kinase C) is found. | Colorado | Colorado | Alvin M Malkinson, PhD | Lung | protein kinase C, BHT | |||
| Mechanisms of Flavonoids as Chemoprotective Agents (2001) | Dr. Gasiewicz attempted to elucidate the mechanisms by which bioflavonoids act to prevent chemical carcinogenesis. | New York | New York | Thomas A Gasiewicz, PhD | Blood/Bone Marrow/Lymph | bioflavonoids | |||
| Mechanisms of Chemoprevention of Skin Tumors by Dietary Fatty Acids (2001) | Dr. Thuillier investigated whether transcription factors known as PPARs (peroxisome proliferator-activated receptors) and certain fatty acids can inhibit carcinogen-induced tumors in mice. | Texas | Texas | Philippe Thuillier, PhD | Skin | PPARs, carcinogens | |||
| Mechanisms of Cachexia in Cancer Patients (1987) | Dr. Torti explored how a hormone-like substance called tumor necrosis factor can affect the genes of fat cells and lead to the development of cachexia in cancer patients. | California | California | Frank M Torti, MD | Other | tumor necrosis factor | |||
| Mechanisms of c-myc Oncogene Regulation by Retinoic Acid Receptors (1992) | Dr. Chou studied how retinoic acid, the active metabolite of vitamin A, regulates the expression of the c-myc oncogene, causing inhibition of cancer cell growth in leukemia and other cancers. | Pennsylvania | Pennsylvania | Robin H Chou, PhD | Blood/Bone Marrow/Lymph | c-myc oncogene, leukemia | |||
| Mechanisms of Anticarcinogenic Componentsfrom Cruciferous Vegetables (2000) | Dr. Talalay conducted clinical studies on the pharmacokinetics and metabolism of glucosinolates and isothiocyanates, derived from young sprouts of crucifers, to elucidate their mechanisms of action in the human body. | Maryland | Maryland | Paul Talalay, PhD | Other | pharmacokinetics, metabolism of glucosinolates and isothiocyanates, cruciferous vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Mechanisms of Anticarcinogenesis by Dietary Dithiothiones (1984) | Dr. Kensler studied how the addition to the diet of dithiothiones, compounds found in cruciferous vegetables, may interfere with the development of liver cancer in rats. | Maryland | Maryland | Thomas W Kensler, PhD | Liver | dithiothiones, cruciferous vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Mechanisms of Anti-inflammatory Breast Cancer Action of Reishi Mushroom (2008) | This study tested the hypothesis that extracts of the medicinal mushroom Reishi inhibit infammatory breast disease in a mouse model by affecting genes that contribute to cancer cell survival, invasion, metastasis and tumor progression. | Puerto Rico | Puerto Rico | Michelle M Martinez, PhD | Breast | Reishi mushroom, inflammatory breast disease, metastasis | |||
| Mechanisms By Which Dietary Carcinogens Induce and Dietary Favonoids Inhibit Programed Cell Death By Lymphocytes (1992) | Dr. Sherr examined how dietary flavonoids decrease suppression of the immune response, and in particular the B cell development, induced by polycyclic aromatic hydrocarbons. | Massachusetts | Massachusetts | David H Sherr, PhD | Other | dietary flavonoid, apigenin | |||
| Mechanism Underlying Induction of Apoptosis During Tyrosine and Phenylalanine Deficiency (1998) | The objective of Dr. Meadow�s research was to elucidate the mechanism by which restricting certain dietary amino acids suppresses the growth and metastasis of melanoma and other tumors in an animal model. | Washington | Washington | Gary G Meadows, PhD | Skin | amino acid deficiency, tyrosine, phenylalanine | |||
| Mechanism of Weight Cycling-Induced Oxidative DNA Damage in Rat Mammary Gland (1998) | Dr. Jen investigated the effects of cyclic weight loss and weight gain on the effect of a mammary carcinogen in rats given the carcinogen plus either a high or a low fat diet. | Michigan | Michigan | Catherine Jen, PhD | Breast | cyclic weight loss and weight gain, high fat diet, low fat diet | |||
| Mechanism of Vitamin D-Mediated Antiproliferative Effects in Prostate Cancer Cells (1998) | Dr. Burnstein investigated the mechanism by which a metabolite of vitamin D, vitamin D3, inhibits growth of prostate cancer cells, possibly by increasing levels of two proteins that act as inhibitors of cell growth. | Florida | Florida | Kerry L Burnstein, PhD | Prostate | Vitamin D3 | |||
| Mechanism of the Antitumor and Anticachectic Effects of n-3 Fatty Acids (2000) | Dr. Sauer explored whether certain human cancer cell lines will show a decreased response to linoleic acid in the presence of n-3 fatty acids, with levels of various physiologic factors as a measure of response. | New York | New York | Leonard A Sauer, MD, PhD | Breast, Liver | linoleic acid, n-3 fatty acids | |||
| Mechanism of Retinoic Acid-induced Differentiation (2000) | Dr. Tighe examined the response of mouse embryonic stem cells to retinoic acid, especially with regard to signaling pathways that are involved in cell differentiation and in regulation of tumor cell growth. | New York | New York | Ann P Tighe, PhD | Other | retinoic acid | |||
| Mechanism of RAR B2 Regulated Growth Inhibition (1996) | Dr. Peacocke continued her studies on the role of various domains of the RAR-beta2 receptor in mediating the cell growth inhibitory effects of retinoids. The research examined if the DNA binding domain of RAR-beta2 and the ligand binding domain of RAR-beta2 are required to inhibit cell proliferation and anchorage-dependent growth. | New York | New York | Monica Peacocke, MD | Skin | retinoic acid receptor beta 2 | |||
| Mechanism of Interaction Between Soy and Radiation for Prostate Cancer (2003) | Dr. Hillman investigated the mechanism(s) by which genestein increases the cell killing caused by radiation of prostate cancer cells in vitro and in a mouse model for prostate cancer in vivo. | Michigan | Michigan | Gilda Hillman, PhD | Prostate | genestein, soy | |||
| Mechanism of Inhibition by Isothiocyanates and Allyl Sulfides in Rat Esophagus (1997) | Dr. Mirvish examined how natural compounds found in vegetables inhibit the action of an esophageal carcinogen, at doses relevant to those occurring in the vegetables. | Nebraska | Nebraska | Sidney S Mirvish, PhD | Esophagus | isothiocyanates, allyl sulfides | Broccoli & Cruciferous Vegetables, Squash | ||
| Mechanism of Fatty Acid Effects (1995) | Dr. Friedman investigated the effect of long (LCFA) and short chain fatty acids (SCFA) derived from dietary fiber on colonocytes. Production of TGF beta-1, a differentiation inducing factor for colonocytes and PKC-beta, a marker of poorly differentiated colon carcinoma cells, is measured in response to their exposure to LCFA and SCFA. | New York | New York | Eileen Friedman, PhD | Colon/Rectum | fiber, TGF beta-1, colonocytes, PKC-beta | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Mechanism of Dietary Indoles in Prevention of Papillomavirus Induced Cancers (1995) | Dr. Auborn investigated the role of indole-3-carbinol present in cruciferous vegetables (cabbage, broccoli, cauliflower and Brussel sprouts) in preventing human papillomavirus tumors (HPV) and their progression. It was hypothesized that indoles, modulators of estrogen metabolism, will prevent growth of HPV-induced tumors and prevent their malignant conversion. | New York | New York | Karen J Auborn, PhD | Cervix | indole-3-carbinol, cruciferous vegetables, human papillomavirus | Broccoli & Cruciferous Vegetables, Legumes (Dry Beans, Peas & Lentils), Squash | ||
| Mechanism of Cancer Prevention by Fiber (2000) | Dr. Cai investigated whether butyrate, from fermentation of dietary fiber, is involved in the induction of heat shock proteins and apoptosis, using human colon carcinoma cells as a model system. | Connecticut | Connecticut | Jiyang Cai, PhD | Colon/Rectum | butyrate, heat shock proteins | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Mechanism of Cancer Chemoprevention by Constituents of Cruciferous Vegetables (2005) | These studies were designed to address the antitumor mechanism and the potential chemopreventive effects of 3, 3�-di-indolylmethanine (DIM), a phytochemical found in cruciferous vegetables. The study examined whether DIM inhibits metastasis of human breast and ovarian cancer cell lines through modulation of chemokine receptors and chemotaxis. | California | California | Oliver Hankinson, PhD | Breast, Ovary | breast cancer, ovarian canecr, DIM, cruciferous vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Mechanism of Action of Indole-3-Carbinol, a Dietary Chemopreventive Agent in Breast Cancer (1994) | Dr. Tiwari demonstrated that indole-3-carbinol, a chemopreventive agent present in cruciferous vegetables, reduces the incidence and multiplicity of spontaneous mammary tumors in mice. Dr. Tiwari extended his studies, using estrogen responsive and non-responsive human breast cancer cells, to characterize the novel mechanism of action of indole-3-carbinol in conjunction with estrogen receptors or estradiol responsive factors. | New York | New York | Raj K Tiwari, PhD | Breast | indole-3-carbinol, estrogen, cruciferous vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Meat Mutagens and Related Polymorphisms and Risk of Breast Cancer in Women (2007) | The aim of this proposal was to evaluate the role of meat intake on breast cancer, using data from the Nurses� Health Study, with emphasis on the major mutagenic heterocyclic amines from prepared meat and breast cancer hormone receptors. | Massachusetts | Massachusetts | Eunyoung Cho, ScD | Breast | heterocyclic amines, meat intake | |||
| Meat Cooking Methods and Colon Carcinogenesis (1994) | As a continuation of her previous studies, Dr. Pence focused on the cooking practices for red meat to determine if it is the method of cooking meat, and not the meat itself, which contributes to colon cancer risk indicated by epidemiological studies. Specifically, she sought to determine the production of heterocyclic aryl amines (HCAs) due to cooking and their role in the initiation and/or promotion of colon carcinogenesis. | Texas | Texas | Barbara C Pence, PhD | Colon/Rectum | meat, cooking methods, heterocyclic aryl amines | |||
| Maternal High-Fat Diet and Breast Cancer Risk Among Offspring (1998) | Dr. Hilakivi-Clarke investigated whether a high fat diet during pregnancy, which leads to elevated serum estradiol levels, can increase breast cancer risk in the female offspring, presumably through changes in estrogen receptor levels and/or function and eicosand metabolism in the mammary gland. | District of Columbia | District of Columbia | Leena A Hilakivi-Clarke, PhD | Breast | pregnancy, high-fat diet, estrogen levels | |||
| Mammary Tumorigenesis: Protective Mechanisms of Dietary Palm Oil (1996) | Dr. Sylvester examined the basis for the protective effect of palm oil against induction of mammary tumors in female rats and whether this effect is due to specific fatty acids or antioxidant constituents which are present in high concentrations in palm oil. | Washington | Washington | Paul W Sylvester, PhD | Breast | palm oil, fatty acids | |||
| Mammary Cancer Protective Effects of Lactational Exposure to Flaxseed or Its Purified Lignan (2000) | Dr. Thompson investigated whether the lignans from flaxseed influence expression of growth factors and rate of proliferation in the mammary gland, and thus might decrease breast cancer. | Canada | Canada | Lilian U Thompson, PhD | Breast | flaxseed | Flaxseed, Legumes (Dry Beans, Peas & Lentils) | ||
| Magnesium, Calcium, and Risk for Colorectal Adenoma (2008) | This study proposed that calcium magnesium ratio infuences the risk of developing colonic adenomas and that polymorphism associated with TRPM7 gene augments the risk. In this molecular epidemiological study, the samples were collected from an ongoing Tennessee Colorectal Polyp Molecular Epidemiological Study. Urinary and erythrocyte calcium and magnesium levels were measured in 300 cases and controls, and TRPM7 polymorphism analyses were carried out on 2000 cases and controls each. | Tennessee | Tennessee | Qi Dai, MD, PhD | Colon/Rectum | calcium, magnesium, TRPM7 gene, Tennessee Colorectal Polyp Molecular Epidemiological study | |||
| Lycopene, Vitamin E, Selenium and Prostate Cancer (2005) | This study assessed whether lycopene, vitamin E and selenium can additively or synergistically reduce the growth of prostate cancer cells and tested whether this interaction relates specifcally to androgen-regulated proliferation. | Illinois | Illinois | John W Erdman, PhD | Prostate | lycopene, vitamin A, selenium | Cherries, Flaxseed, Squash, Grapefruit | ||
| lycolytic Metabolism as a Novel Therapeutic Target in Medulloblastom (2012) | Dr. Gershon will target the unusual way medulloblastoma cells use glucose to see if a ketogenic diet � high fat, low-carbohydrate � will have an anti-tumor effect by forcing the tumor cells to burn fat rather than glucose from carbohydrates. | North Carolina | North Carolina | Timothy Gershon, MD, PhD | Brain | ||||
| Luteolin as Dietary Chemopreventive Agent in Colorectal Cancer (2005) | This study examined the mechanism by which luteolin, a naturally occurring favonoid, inhibits colon cancer in animal models. | North Carolina | North Carolina | Christian Jobin, PhD | Colon/Rectum | luteolin, flavonoids | |||
| Lunasin, a Novel Cancer Preventive Seed Peptide (2005) | This study examined how the peptide lunasin � found in soy, wheat and barley � can be used to delay or prevent prostate cancer in a mouse model. | California | California | Benito O de Lumen, PhD | Prostate | peptide, lunasin, soy, wheat, barley | |||
| Localized Folate Status and Cancer (1991) | Dr. Steele investigated if a deficiency of folate, a B-vitamin, in the diet causes a deficiency in folate in the colon tissue and thereby possibly increases the risk for developing colon cancer. | Wisconsin | Wisconsin | Robert D Steele, PhD | Colon/Rectum | folate deficiency | Legumes (Dry Beans, Peas & Lentils) | ||
| Liver Phospholipids of Normal and Tumor-Bearing Rats (1989) | Dr. Kritchevsky examined how phospholipids, an important group of substances found throughout the body, are affected by either the presence of breast cancer or by a diet which influences the chances of developing breast cancer. | Pennsylvania | Pennsylvania | David Kritchevsky, PhD | Breast | phospholipids, diet | |||
| Lipotrope Nutrition and Cancer Chemotherapy (1987) | Dr. Rogers studied how a deficiency of choline, methionine, or folic acid, which are nutrients central to one-carbon metabolism and cellular reproduction, can increase the risk of developing a second primary cancer in patients given chemotherapy, and how this might be prevented by dietary supplementation with choline. | Massachusetts | Massachusetts | Adrianne E Rogers, MD | Liver | choline, methionine, folic acid | |||
| Lipid Modulation of Jak2-Stat5 Signal Transduction Pathway in Prostate Cancer (2003) | These studies were designed to examine the hypothesis that saturated and omega-6 polyunsaturated fatty acids enhance Jak2-Stat5 signal transduction in prostate cancer cells, thereby promoting their survival and proliferation, whereas omega-3 polyunsaturated fatty acids oppose Jak2-Stat5 signalling and reduce the growth of prostate cancer cells. | Pennsylvania | Pennsylvania | Marja Nevalainen, MD, PhD | Prostate | omega-3, omega-6, PUFAs, chemotherapeutic nucleoside drugs | |||
| Lipid Metabolism in Cancer (1983) | Dr. Lokich examined how the metabolism of fat in patients with colon cancer differs from the metabolism of fat in those without cancer, in order to help explain why so many cancer patients lose weight during their illness. | Massachusetts | Massachusetts | Jacob J Lokich, MD | Colon/Rectum | metabolism | |||
| Lipid Markers of Caloric Restriction: Pertinence to Cancer (1992) | Dr. Kritchevsky evaluated whether the inhibition of spontaneous and induced carcinogenesis by caloric restriction may be related to changes in the phospholipid profile that occurs in the transformation of normal cells to cancer cells. This was a collaborative study supported by AICR and the Food and Drug Administration�s National Center for Toxicological Research. | Pennsylvania | Pennsylvania | David Kritchevsky, PhD | Other | caloric restriction, phospholipids | |||
| Limonene, Membranes, and Malignant Cell Growth (1993) | Dr. Hohl built on his past observation that limonene, a natural component of citrus fruits, might prevent growth of leukemic cells by blocking necessary components of tumor cell growth. He looked at the effects of limonene and certain polyunsaturated fatty acids on tumor cell growth. | Iowa | Iowa | Raymond J Hohl, MD, PhD | Blood/Bone Marrow/Lymph | limonene, citrus fruit, leukemia, polyunsaturated fatty acids | Soy, Grapefruit | ||
| Limonene and Leukemia Cell Growth (1992) | Dr. Hohl sought to determine whether limonene, a natural component of citrus fruits, might prevent the growth of leukemia cells by blocking ras-oncogene expression and preventing isoprenylation to form active growth promoting proteins necessary for tumor cell growth. | Iowa | Iowa | Raymond J Hohl, MD, PhD | Blood/Bone Marrow/Lymph | limonene, citrus fruit, leukemia | Grapefruit | ||
| Ligand Activation of Peroxisome Proliferator-Activated Receptors in Rodent Mammary Tumor Models (1998) | Dr. Gimble studied whether natural or synthetic peroxisome proliferator-activated receptor ligands would protect against mammary carcinogenesis in rats given a carcinogen and fed a diet high in either fish or corn oil. | Oklahoma | Oklahoma | Jeff M Gimble, MD, PhD | Breast | peroxisome proliferator-activated receptor ligands, fish oil, corn oil | |||
| Leukemia-associated Chromosomal Abnormalities: the Role of Prenatal Exposure to Dietary Topoisomerase II Inhibitors and Mutation in the ATM Gene (2006) | This study explored whether dietary favonoids such as genistein and quercetin might have a harmful effect on certain genes and increase the risk of infant leukemia. | Netherlands | Netherlands | Sahar Barjesteh van Waalwijk van Doorn-Khosrovani, PhD | Blood/Bone Marrow/Lymph | flavonoids, genistein, quercetin, leukemia | Blueberries, Apples | ||
| Lean Beef Versus Total Fat in Colon Carcinogenesis (1992) | Dr. Pence sought to determine whether it is the high fat or the high protein in meat, or fat from other sources, that is responsible for the increase in colon cancer. | Texas | Texas | Barbara C Pence, PhD | Colon/Rectum | meat, fat | |||
| Joint Effect of Diet, MTHFR and DNMT1 on Risk of Colorectal Neoplasia: Association and Linkage Studies (2003) | Dr. Wiesner studied a possible cancer gene pathway, the DNA methylation pathway, to determine if the type of fat enriched diet and underlying genes are associated with colon cancer. | Ohio | Ohio | Georgia L Wiesner, MD | Colon/Rectum | DNA methylation pathway, fat enriched diet | |||
| Is Flavonoid Intake from Food and Supplements a Cofounder in Breast Cancer Recurrence? (2000) | Dr. Dwyer studied the dietary flavonoid intake of postmenopausal women who were enrolled in the Women�s Intervention Nutrition Study and who have been treated for breast cancer. | Massachusetts | Massachusetts | Johanna Dwyer, RD, DSc | Breast | flavonoid, postmenopausal breast cancer, recurrence | |||
| Iron, Hemochromatosis (HFE) and Estrogen in Breast Cancer (2003) | These studies were designed to determine the effects of estrogen on the growth of mammary cancer cells that have a mutation in the hemochromatosis gene, causing them to overload on iron. | Wisconsin | Wisconsin | Christopher R Chitambar, MD | Breast | iron, estrogen, hemochromatosis | Legumes (Dry Beans, Peas & Lentils) | ||
| Iron Increases Breast and Prostate Cancer Cells Invasion (2002) | Dr. Kajdacsy-Balla investigated whether increased cellular iron levels are involved in the invasive growth of prostate and breast cancer cells and what factors can modulate the invasive potential of the cancer cells. | Wisconsin | Wisconsin | Andre Kajdacsy-Balla, MD, PhD | Breast, Prostate | prostate, breast, iron | Legumes (Dry Beans, Peas & Lentils) | ||
| Iron and the Risk of Cancer (1992) | Dr. McGlynn examined people in China to determine if high stores of body iron are associated with increased cancer risk. She looked at iron levels in hair, nails and blood trying to determine the best judge of cancer risk and whether iron storage is under genetic control. | Pennsylvania | Pennsylvania | Katherine McGlynn, PhD | Other | iron, China, genetics | Legumes (Dry Beans, Peas & Lentils) | ||
| Iron and the Chemopreventive Activity of Curcumin (2004) | This study determined whether curcumin, a dietary spice which ties up iron, can infuence intestinal tumor formation in an experimental mouse model prone to develop such tumors. | North Carolina | North Carolina | Suzy V Torti, PhD | Colon/Rectum | Curcumin | Legumes (Dry Beans, Peas & Lentils) | ||
| Iron and Mammary Carcinogenesis (1991) | Dr. Thompson investigated how iron in the diet might influence different stages of the cancer process giving rise to either increased or decreased incidences of breast cancer. His studies sought to determine whether there is an optimal level of iron that protects against cancer. | Colorado | Colorado | Henry J Thompson, PhD | Breast | iron | Legumes (Dry Beans, Peas & Lentils) | ||
| Investigation of the Role of a Vitamin D-Inducible Gene in Mammary Tumorigenesis (1997) | Dr. Voigt tested whether 1,25-dihydroxyvitamin D3 inhibits the growth of rat mammary tumor cells due to an increase in expression of the UDP-1 gene which suppresses the tumorigenic phenotype. | Pennsylvania | Pennsylvania | Jeffrey M Voigt, PhD | Breast | 1,25-dihydroxyvitamin D3, UDP-1 gene | |||
| Investigation of the Mechanisms by Which a Diet High in Lard Enhances Mammary Tumorigenesis in Rats (1983) | Dr. Rogers and her colleagues studied possible mechanisms by which a high-lard diet might increase mammary tumor development. | Massachusetts | Massachusetts | Adrianne E Rogers, MD | Breast | high-fat diet | |||
| Investigation of the Influence of Peanut Agglutinin (PNA) on Cancer Cell Metastatic Spread (2010) | This laboratory study is investigating the possible influences of the peanut protein agglutinin (PNA) promoting the spread of tumor cells to remote sites and enhancing metastasis. | United Kingdom | United Kingdom | Lu-Gang Yu, MD, PhD | Colon/Rectum | peanut agglutinin, cancer survival | |||
| Investigation of the Induction of Malignancy in Celiac Disease by Dietary Gluten (1990) | Dr. Ciclitira investigated how celiac disease, a type of food allergy from gluten in wheat, rye, and grain products, is associated with increased risk for developing malignant melanoma of the intestine. He sought to correlate differences in the genetic material, DNA, and proteins in celiac disease patients with the altered immunity, food allergies, and increased cancer risk in these patients. | United Kingdom | United Kingdom | Paul J. Ciclitira, FRCP, PhD, MD, MRCP | Colon/Rectum | celiac disease, gluten, melanoma, genetics, DNA, food allergies | Legumes (Dry Beans, Peas & Lentils) | ||
| Intervention Study of Flaxseed in Postmenopausal Women: Effects on Biomarkers (2003) | Dr. Sturgeon�s studies were designed to determine whether flaxseed supplementation of the diet of postmenopausal women has a beneficial effect on biomarkers of cancer risk. | Massachusetts | Massachusetts | Susan R Sturgeon, DrPH | Other | flaxseed, postmenopausal women, biomarkers | Flaxseed | ||
| Interactive Effect of Flaxseed and Trastuzumab in Reducing the Growth of Human Breast Tumors Over Expressing HER2 (2009) | Dr. Thompson studied whether pairing a common chemotherapy drug with dietary intake of flaxseed may make the drug more effective and less toxic. | Canada | Canada | Lilian U Thompson, PhD | Breast | flaxseed, trastuzumab, her2 | Flaxseed | ||
| Interactions of Retinoic Acid and Transforming Growth Factor Beta in Chemoprevention of Human Papillomavirus-induced Cancer (1995) | Dr. Creek examined the mechanism underlying the effects of retinoids in chemoprevention of human papillomavirus(HPV)-induced cancer. He tested the hypothesis that the retinoid induced growth inhibition of HPV is mediated by the Growth Factor Beta. These studies should help to clarify the mechanism by which the DNA of cancer-causing HPV types insert themselves into the genome of the host cell, an important first step in the development of cervical cancer. | South Carolina | South Carolina | Kim E Creek, PhD | Cervix | retinoids, HPV, growth factor beta | |||
| Interaction of Garlic and Selenium in the Inhibition of Breast Cancer (1994) | Dr. Liu investigated the synergistic effect of allyl compounds within garlic and dietary selenium in the inhibition of experimentally DMBA-induced breast cancer. He also studied the mechanism of action by which the various garlic compounds influence the ability of selenite to depress DMBA-DNA binding and determine the optimal combination of these substances to maximize the reduction of this binding. | Pennsylvania | Pennsylvania | Jin-Zhou Liu, MD, PhD | Breast | garlic, selenium | |||
| Interaction of Dietary Aflatoxin and Hepatitis B Virus in Hepatocellular Carcinoma (1986) | Dr. Vyas studied how liver cells infected with the hepatitis B virus may interact with aflatoxin B-1, a mold-generated toxin which sometimes contaminates grain and peanuts, to initiate liver cancer. | California | California | Girish N Vyas, PhD | Liver | Hepatitis B, aflatoxin B-1 | |||
| Interaction Between Vitamin A and Phosphatidylinositol 3-kinase in Colorectal Tumor Metastasis (2008) | This study tested the hypothesis that retinol (vitamin A) inhibits the metastasis of cancer cells through a unique post-translational mechanism involving inactivation of phosphatidylinositol 3-kinase (PI3K) enzyme. First, the effect was observed in mice consuming diets with vitamin A, and then it examined how vitamin A interacts with PI3K at the molecular level. | Texas | Texas | Michelle Lane, PhD | Colon/Rectum | retinol, phosphatidylinositol 3-kinase | Legumes (Dry Beans, Peas & Lentils) | ||
| Insulin Resistance in the Etiology of Colorectal Neoplasia (2000) | Dr. Platz explored the relationship between insulin resistance and hyperinsulinemia and risk of developing colon cancer in a large population. | Maryland | Maryland | Elizabeth A Platz, PhD | Colon/Rectum | insulin resistance, hyperinsulinemia | |||
| Insitutional Training Grant on Cancer Prevention Research (2007) | 0 | Guatemala | Guatemala | Noel Solomons, M.D. | Other | 0 | |||
| Insitutional Training Grant on Cancer Prevention Research (2007) | 0 | Guatemala | Guatemala | Noel Solomons, MD | Other | ||||
| Insitutional Training Grant on Cancer Prevention Research (2007) | 0 | Guatemala | Guatemala | Noel Solomons, MD | Other | ||||
| Insitutional Training Grant on Cancer Prevention Research (2007) | 0 | Guatemala | Guatemala | Noel Solomons, MD | Other | ||||
| Inositol Pentakisphosphate, a Novel Bioactive Compound for the Prevention and Treatment of Human Cancer (2006) | The study investigated if inositol pentakisphosphate (IP5) exerts its antineoplastic effects through inhibition of PI3K/Akt signalling pathway activation and tested its effcacy in combination therapy with other bioactive compounds against ovarian and breast cancer. | United Kingdom | United Kingdom | Marco Falasca, PhD | Breast, Ovary | inositol pentakisphosphate, bioactive compounds, ovarian cancer, breast cancer | Legumes (Dry Beans, Peas & Lentils) | ||
| Inhibition of Prostate Carcinogenesis by Flavokawain B, a Novel Chalcone from the Kava Plant (2007) | This study investigated the effect of flavokawain B on prostate cancer cell proliferation and apoptosis, using both the TRAMP mouse model and several prostate cancer cell lines. | California | California | Xiaolin Zi, PhD, MD | Prostate | flavokawain B, kava plant | |||
| Inhibition of Nitrosamine Activation by Allyl Sulfides (2000) | Dr. Mirvish sought to determine the mechanism by which allyl sulfides from garlic inhibit the carcinogenicity of nitrosamines. | Nebraska | Nebraska | Sidney S Mirvish, PhD | Esophagus, Liver | allyl sulfides, garlic, nitrosamines | |||
| Inhibition of EGF Receptor Activation by Curcumin (1994) | Curcumin, the major active yellow pigment of the spice turmeric, has been shown to have anti-proliferative properties in human tumor cell cultures. Dr. Kumar investigated the inhibitory effects of curcumin on carcinogen stimulation or activation of cellular and molecular pathways in MH3T3 cells. He also examined whether there is inhibition of mitogen-induced activation of epidermal growth factor receptors. | Pennsylvania | Pennsylvania | Rakesh Kumar, PhD | Other | curcumin, epidermal growth factor receptors, | |||
| Inhibition of DNA Adduct Formation of 2-amino-1-methyl-6-phenylimidazo-(4,5-b)pyridine (PhIP) in the Mammary Gland by Dietary d-Limonene (1994) | Dr. Schut studied the effect of the dietary constituent, d-Limonene, on the mutagenic potential of charred protein-rich foods. One of the most abundant mutagenic compounds in cooked hamburger meat is PhIP, which has been shown to induce mammary tumors in the rat. Dr. Schut investigated the potential of d-Limonene to inhibit the PhIP formation in the mammary gland. These novel studies aimed to identify a naturally-occurring dietary chemopreventive agent against breast cancer. | Ohio | Ohio | Herman A.J. Schut, PhD | Breast | d-Limonene, cooked meat, PhIP | Grapefruit | ||
| Inhibition of DMBA-Induced Mammary Carcinogenesis by Carnosol (1992) | Dr. Singletary sought to determine whether carnosol, an antioxidant and active component of rosemary, might inhibit DMBA-induced mammary gland cancer in rats by preventing DNA adduct formation. | Illinois | Illinois | Keith W Singletary, PhD | Breast | carnosol, rosemary | |||
| Inhibition of Colon Carcinogenesis by Phytate (1988) | Dr. Shamsuddin sought to confirm his observation that phytate, a natural constituent of grains, seems to reduce the incidence of colon cancer after exposure to a powerful carcinogen. | Maryland | Maryland | Abulkalam M Shamsuddin, MD, PhD | Colon/Rectum | phytate | |||
| Inhibition of Carcinogenesis by Nutritional Modifications (1983) | Dr. Boutwell sought to determine the optimal levels in the diet of two chemicals, one a derivative of vitamin A and the other an enzyme inhibitor, which will prevent the development of skin cancer in mice. | Wisconsin | Wisconsin | Roswell K Boutwell, PhD | Skin | enzyme inhibitor | |||
| Inhibition of Breast Cancer by Soybean Isoflavones (1987) | Dr. Barnes explored the possibility that breast cancer is much less common in Asia because a substance found in soybeans may inhibit the development of breast cancer by interfering with the effect of estrogen on the growth of certain tumors. | Alabama | Alabama | Stephen Barnes, PhD | Breast | Soybean isoflavones | |||
| Inhibition of Bladder Tumorigenesis by Calorie Restriciton: Mechanistic Studies (1997) | Dr. Hursting examined the effect of glucocorticoids such as corticosterone on the decrease in bladder tumors in mice given a bladder carcinogen while on a moderately restricted diet. | Texas | Texas | Stephen D Hursting, PhD, MPH | Bladder | caloric restriction, glucocoricoids, corticosterone | |||
| Influence of Suboptimal Zinc in Utero on the Development of Immunological Defenses Against Cancer (1985) | Dr. Fraker investigated the possibility that a poor diet during pregnancy may increase the risk of a child later developing cancer, by examining in mice whether a maternal zinc deficiency results in offspring whose immune systems have a reduced capability of resisting cancer. | Michigan | Michigan | Pamela J Fraker, PhD | Other | pregnancy, zinc deficiency | |||
| Influence of Other Dietary Factors on the Bioavailability and Cancer Preventive Activities of the Green Tea Polyphenol, (-)-epigallocatechin-3-gallate (2005) | This study evaluated the effcacy of EGCG as a colon cancer preventive agent when combined with genistein or curcumin, in both colon cancer cell lines and in two mouse models. | New Jersey | New Jersey | Joshua D Lambert, PhD | Colon/Rectum | EGCG, green tea, genistein, curcumin | |||
| Influence of Omega-3 and Omega-6 Fatty Acid Sources on UV-Carcinogenesis and Immunoresponsiveness (1990) | Dr. Black fed animals diets with fats from corn oil, beef tallow, or menhaden fish oil in different amounts, to determine which diets result in the fewest tumors that might be induced by UV-radiation or tumor transplants. Differences in saturation in the dietary fats might enhance the immune response and increase a person�s natural ability to fight cancer. | Texas | Texas | Homer S Black, PhD | Skin | omega-3, omega-6, corn oil, beef tallow, menhaden fish oil, UV radiation | |||
| Influence of Docosahexaenoic Acid (DHA 22:6n-3) on p21 ras Membrane Binding and Function (2000) | Dr. Chapkin investigated how the fatty acids from fish oil influence the risk for colon cancer development, with emphasis on ras function and binding to membranes. | Texas | Texas | Robert S Chapkin, PhD | Colon/Rectum | fish oil, Ras function, docosahexaenoic acid | |||
| Influence of Cyclophosphamide, Oxygen Radicals and Dietary Vitamin-E on Lipid Composition and Fluidity of Lung Membranes (1987) | Dr. Patel studied how the normal composition and functioning of cell membranes in the lungs can be damaged by an anti-cancer drug or by highly unstable metabolites of oxygen, and whether this might be prevented by vitamin E in the diet. | Florida | Florida | J.M. Patel, PhD | Other | oxygen radicals | |||
| Influence of Carnitine and Nicotinic Acid on Cancer Cachexia (1994) | The hypothesis that was investigated was that aberrations in lipid metabolism may constitute a substantial portion of the energy drain associated with cancer cachexia. Dr. Chance studied the effect of supplementation of dietary carnitine and nicotinic acid on tumor bearing animals and the reduction of cachexia by stimulating mitochondrial oxidation of lipids. A combination of these two nutrients with clenbuterol, a drug, could potentially further reduce muscle wasting and cachexia. | Ohio | Ohio | William T Chance, PhD | Other | lipid metabolism, carnitine, nicotinic acid, mitochondrial oxidation, clenbuterol | |||
| Influence of Caloric Restriction on Brain Tumor Growth and Angiogenesis (2001) | Dr. Seyfried used both mouse and human brain tumor cells, implanted intracerebrally in mice, to evaluate the effects of 20 or 40% caloric restriction on tumor growth and associated factors such as angiogenesis and apoptosis. | Massachusetts | Massachusetts | Thomas N Seyfried, PhD | Nervous System | caloric restriction, angiogenesis, apoptosis | |||
| Influence of Amount and Source of Calories on Chemically Induced Tumors in Rats (1983) | Dr. Kritchevsky studied whether restricting calories, as opposed to fat, in the diet can prevent the development of breast or colon cancer. | Pennsylvania | Pennsylvania | David Kritchevsky, PhD | Breast, Colon/Rectum | caloric restriction, colon cancer | |||
| Inflammatory Pathways in Curcumin Chemoprevention (2006) | This postdoctoral training was used to gain experience in nutrition and the biological aspects of cancer interactions and to determine the potential of curcumin to decrease colon cancer risk. | Michigan | Michigan | Shaiju Kakkanadan-Vareed, PhD | Colon/Rectum | Curcumin | |||
| Induction of Melanoma Differentiation by Retinoic Acid: Early Response Genes (1999) | Dr. Niles examined the effect of retinoic acid on genes that cause melanoma cells to undergo differentiation and apoptosis. | West Virginia | West Virginia | Richard M Niles, PhD | Skin | retinoic acid, melanoma, apoptosis | |||
| Induction of Iron-Metabolizing Enzymes by Dietary Chemopreventive Agents (1995) | Dr. Primiano investigated the induction of iron related enzymes and storage proteins, heme oxygenase and ferritin, by 1,2-dithiole-3-thione (D3T) in a hepatic cell line and sought to determine whether D3T alters iron homeostasis and reduces susceptibility to oxidative stress. | Maryland | Maryland | Thomas Primiano, PhD | Liver | iron, D3T, heme oxygenase, ferritin | Legumes (Dry Beans, Peas & Lentils) | ||
| Induction of Carcinogen Detoxifying Enzymes by the Dietary Anticarcinogen Elagic Acid (1994) | Dr. Barch has shown that part of the anticarcinogenic activity of ellagic acid, found in a variety of fruits and nuts, comes from the ability of ellagic acid to increase the production of glutathione S-transferase Ya and quinone reductase, two detoxification proteins that destroy cancer-causing chemicals. This study examined the signals ellagic acid uses to tell the body to make detoxification enzymes. | Illinois | Illinois | David H Barch, MD | Other | ellagic acid | Blueberries, Cherries | ||
| Increasing the Effectiveness of Bioreductive Antitumor Agents (1999) | Dr. Begleiter investigated how increased levels of the DT-Diaphorase enzyme (DTD) enhance the antitumor activity of chemotherapeutic agents such as mitomycin C, in addition to searching for diet-based enzyme inducers, which increase the activity of DTD. | Canada | Canada | Asher Begleiter, PhD | Other | DT-diaphorase enzyme, mitomycin C | |||
| Increased Efficacy of Supplemental Nutrition in Cancer with Clenbuterol Treatment (1990) | Dr. Foley-Nelson sought to determine combinations that will stop tumors from growing and at the same time will prevent the loss of body weight and the wasting away of muscle tissue. The treatments she studied included clenbuterol, which prevents loss of muscle weight, acivicin, which stops tumor growth but also causes muscle weight loss, and insulin, which increases the metabolism of glucose to possibly counter the muscle weight loss. | Ohio | Ohio | Teri Foley-Nelson, PhD | Other | clenbuterol, acivicin, insulin | |||
| Increased Efficacy and Amelioration of Side Effects of Radiotherapy (2001) | Using mice implanted with human colon cancer cells, Dr. Hardman investigated the ability of an antioxidant-free fish oil concentrate to increase the efficacy of cancer chemotherapy drugs and decrease the intestinal damage from the drugs. | Texas | Texas | W. Elaine Hardman, PhD | Colon/Rectum | fish oil, chemotherapy | |||
| Increased Dietary Supply of Glutamine to Improve Chemotherapeutic Efficacy of Asparaginase (2004) | Using a mouse model of acute lymphoblastic leukemia, this study investigated whether the provision of a dietary supply of the amino acid glutamine can reduce the toxic side effects and increase the effcacy of tumor killing during asparaginase therapy. | Indiana | Indiana | Tracy G Anthony, PhD | Blood/Bone Marrow/Lymph | acute lymphoblastic leukemia, glutamine | |||
| Increased Dietary Omega-3 Fatty Acids to Selectively Sensitize Cancer Cells to Chemotherapy (1993) | Dr. Hardman demonstrated that polyunsaturated fatty acids (PUFA) in fish oil increase lipid peroxidation in the cellular membrane of a tumor appearing to cause the malignant tumor cells to die. Dr. Hardman sought to validate this hypothesis by enhancing lipid peroxidation by the pro-oxidant ferric citrate making cancer cells more sensitive to a chemotherapy drug. | Texas | Texas | W. Elaine Hardman, PhD | Breast | PUFA, fish oil, lipid peroxidation, ferric citrate | Legumes (Dry Beans, Peas & Lentils) | ||
| Inactivation of CYP1A1 By Flavones-Lung Cancer Prevention (2002) | Dr. Walle used a compound derived from plants to determine whether it can prevent or inhibit the actions of enzymes that activate or deactivate carcinogens, using human bronchial cells as the model system. | South Carolina | South Carolina | Thomas Walle, PhD | Lung | CYP1A1, flavones, carcinogens | |||
| In Vitro Effects of Resveratrol During Early Stages of Intestinal Tumorigenesis (1999) | Dr. McEntee used the Min/+ mouse colon tumor model to determine whether resveratrol, an antioxidant from grapes, can cause regression or prevention of the intestinal adenomas in the Min mouse, and whether it acts synergistically with sulindac to eliminate the intestinal tumors. | Tennessee | Tennessee | Michael F McEntee, PhD, DVM | Colon/Rectum | resveratrol, grapes, antioxidants, intestinal adenoma, sulindac | Blueberries | ||
| Improving Outcome of Cancer Anorexia Based on Mechanistic Understanding and Novel Nutritional Therapeutic Strategies (1995) | Dr. Meguid tested his hypothesis based on clinical and experimental data that cancer anorexia is mediated by increased serotonin synthesis in the hypothalamus. He examined if cancer anorexia can be reversed by depleting the hypothalamus of the serotonin precursor, tryptophan, leading to physiological ways to improve the feeding behavior of cancer patients. | New York | New York | Michael M Meguid, MD, PhD, FACS | Other | Cachexia, serotonin, tryptophan | |||
| Implications of Vitamin A Intake for Radiotherapy (1999) | Dr. Rockwell investigated the role of vitamin A tissue stores in lung toxicity and tumor metastases after chemo- or radiotherapy, with the aim of decreasing the toxicity of these therapies in lung cancer patients. | Connecticut | Connecticut | Sara Rockwell, PhD | Lung | metastasis , radiotherapy | |||
| Impact of Dietary Intervention in Men with Prostate Cancer (2000) | In a dietary intervention trial, Dr. Babaian sought to determine whether men who are asymptomatic for prostate cancer can follow a reduced fat diet containing soy protein every day and attend various clinical support group sessions. | Texas | Texas | Richard J Babaian, MD | Prostate | low-fat diet, soy protein, clinical support groups | |||
| Immunomodulation by Fumonisin B1 and Its Role in Cancer (1993) | Dr. Merrill looked at how a fungus, Fumonisin B1, found on agriculture products affects the immune system in cancer development. This fungus prevents the formation of specific complex lipids that are involved in the regulation of cell growth and differentiation. | Georgia | Georgia | Alfred H Merrill, PhD | Other | fumonisin B1 | |||
| Immunobiology of Dietary Fat-Modulated UV-Carcinogenesis (1998) | Dr. Black examined the roles of immune function and epidermal cycloxygenase activity and gene expression, in relation to dietary lipid levels, and how they affect the carcinogenic effects of ultraviolet irradiation, as a means to suppress skin cancer. | Texas | Texas | Homer S Black, PhD | Skin | immune function, cycloxygenase, dietary lipids, UV irradiation | |||
| ignan or fish oil supplement to reduce breast cancer progression in mic (2011) | Dr. Ford is studying whether bioactive compounds found in flaxseed and fish oil have a positive effect on obesity biomarkers and thereby reduce breast cancer incidence and progression. | Texas | Texas | Nikki Ford, PhD | Breast | Plant/Food Components | |||
| ietary folate interventions in a mouse model of castration recurrent prostate cancer (2012) | In Dr. Smiraglia�s new study, he is comparing the development of prostate cancer in mice fed a folate-restricted diet to mice that are fed a diet that is supplemented with folate. He hopes to show that dietary folate restriction, when combined with androgen deprivation therapy, will result in decreased cancer recurrence. | New York | New York | Dominic Smiraglia, PhD | Prostate | ||||
| iet induced obesity and breast cancer: Protective role of vitamin (2012) | Using a mouse model of breast cancer, Dr. Feldman hopes to develop vitamin D as a therapy to protect against fatness-enhanced breast cancer and to investigate whether vitamin D added to the diet protects against the negative effects of fatness. | California | California | David Feldman, MD | Breast | ||||
| Identification of Minor Dietary Anticarcinogenic Components in Vegetables (1992) | Dr. Talalay, using a novel technique of harnessing endogenous cellular mechanisms, sought to identify minor chemicals that are potent inducers of Phase 2 protective enzymes. After isolating one such potent inducer (sulforaphane) from broccoli, he expanded his studies to identify others and explain their mechanisms of action. | Maryland | Maryland | Paul Talalay, PhD | Other | sulforaphane, broccoli | Broccoli & Cruciferous Vegetables | ||
| Identification of Dietary Inhibitors of Carcinogenesis (1983) | Dr. Wattenberg sought to identify the anti-cancer compounds in cocoa beans which could prevent the development of breast, lung, and stomach cancer in rodents, and the anti-cancer compound in standard laboratory rat chow which could prevent gastrointestinal cancer in mice. | Minnesota | Minnesota | Lee W Wattenberg, PhD | Breast, Lung, Stomach | cocoa beans | |||
| Identification of Citric Acid Induced Apoptosis Genes (1996) | Based on preliminary data, Dr. Liang observed that citrate, a major constituent of citrus fruits, induces apoptosis in glioma cells. He studied the mechanism of citrate dependent apoptosis in glioma cells by identifying and cloning genes whose transcription is induced or repressed in response to citrate. | Colorado | Colorado | Bertrand C Liang, MD | Nervous System | citrus fruits, citrate | Apples, Cherries | ||
| How Do Flavonoids Kill Human Breast Cancer Cells? (1998) | Dr. Loo investigated whether or not dietary flavonoids protect against breast cancer by damaging DNA through a p53 dependent stimulation of apoptosis. | North Carolina | North Carolina | George Loo, PhD | Breast | flavonoids, DNA damage, apoptosis | |||
| Hormones and Diet in Women in High Breast Cancer Risk (1983) | Dr. Rose investigated if lowering the amount of fat in the diet to 20% of calories can lead to a reduction in the levels of the hormones estrogen and biologically-active prolactin circulating in the blood of women who are suffering from severe cystic breast disease and who may be at special risk of developing breast cancer. | New York | New York | David P Rose, MD, PhD | Breast | estrogen, prolactin, cystic breast disease | |||
| Hormonal and Growth Factor Modulation of Diet-Induced Hepatic Carcinogenesis (1986) | Dr. Betschart studied how hormones and other hormone-like substances may be involved in regulating the growth of tumors, by attempting to determine how the liver cells respond to these substances and how this causes cells to become cancerous. | Pennsylvania | Pennsylvania | James M Betschart, PhD | Liver | hormones, growth factor | |||
| Herbal Supplements and Prevention of Colon Cancer (2001) | Dr. Wargovich used certain constituents of herbal dietary supplements as models for modulating COX1 and COX2 expression in rat colon, as well as their effects on cellular receptors and induction of apoptosis. | South Carolina | South Carolina | Michael J Wargovich, PhD | Colon/Rectum | herbal supplements, COX1 and COX2 expression | |||
| Hepatitis B and Liver Cancer (1991) | Dr. Sell sought to determine whether dietary cadmium might enhance the ability of Hepatitis B virus to increase the risk for liver cancer. | Texas | Texas | Stewart Sell, MD | Liver | cadmium, Hepatitis B | |||
| Growth Inhibition of Prostate Cancer Cell by Selenomethionine Through MAP Kinase Signaling (2005) | This post-doctoral study sought to understand the role that the ERK1/2 signalling pathway plays in growth inhibition of androgen-sensitive and insensitive prostate cancer cells (LNCaP and DU145). The study also examined ERK1/2 pathway proteins as markers of the clinical effcacy of selenium in patients treated on a selenium supplementation trial for prostate cancer. | Arizona | Arizona | Durga Prasad P Cherukuri, PhD | Prostate | Selenium, ERK1/2 signalling pathway | |||
| Growth Arrest- and Cell Death-Gene Mediated Breast Cancer Prevention by Selenium (1997) | Dr. Lu studied the effect of the naturally occurring selenium compound, methylselenocysteine, on both cell cycle control in rats given a carcinogen, as well as examining the expression the expression of 6 genes involved in regulation of cell cycles and programmed cell death. | Colorado | Colorado | Junxuan Lu, PhD | Breast | selenium, methylselenocysteine | |||
| Green Tea Polyphenols in the Prevention of Breast Cancer Initiation (2010) | This cell study is examining how green tea may protect against breast cancer initiation by preventing changes to DNA and its associated proteins. These epigenetic changes do not involve DNA mutations. | Alabama | Alabama | Trygve Tollefsbol, PhD, DO | Breast | breast cancer initiation, epigenetics, telomerase, defined genetic elements, tumorigenesis, green tea | |||
| Green Tea Inhibition of Epithelial to Mesenchymal Transition of Breast Cancer Cells (2006) | This study examined how green tea polyphenols block the transition of human breast cancer cells from epithelial to mesenchymal in animal models. | Massachusetts | Massachusetts | Gail E Sonenshein, PhD | Breast | green tea polyphenols | |||
| Green Tea and Epigenetic Regulation of Wnt Signaling (2007) | This study investigated the epigenetic suppression of the WNT signalling pathway in breast cancer and developed nutritional strategies to improve treatment, because it was suggested that the green tea compound EGCG may synergize with demethylating agents to improve chemotherapy. | Massachusetts | Massachusetts | Amy Yee, PhD | Breast | Green tea, EGCG, Wnt signaling | |||
| GPx-1 Polymorphisms, Selenium and Cancer (2010) | This cell study is examining the hypothesis that individual differences in the gene sequence of a selenium-containing enzyme (GPx-1) determine how the enzyme interacts with selenium and its effectiveness in protecting cells from DNA damage that could lead to mutations and eventually result in cancer. The experiments plan on indicating the amount of dietary selenium certain individuals or subpopulations need for the greatest cancer-protective benefits. | Illinois | Illinois | Anita Jerome-Morais, PhD | Multiple Sites | selenium, glutathione peroxidase-1, GPx-1 polymorphisms, DNA damage | |||
| GPx-1 Polymorphisms, Selenium and Cancer (2010) | This cell study is examining the hypothesis that individual differences in the gene sequence of a selenium-containing enzyme (GPx-1) determine how the enzyme interacts with selenium and its effectiveness in protecting cells from DNA damage that could lead to mutations and eventually result in cancer. The experiments plan on indicating the amount of dietary selenium certain individuals or subpopulations need for the greatest cancer-protective benefits. | Illinois | Illinois | Anita Jerome-Morais, PhD | Colon/Rectum | selenium, glutathione peroxidase-1, GPx-1 polymorphisms, DNA damage | |||
| GPx-1 Polymorphisms, Selenium and Cancer (2010) | This cell study is examining the hypothesis that individual differences in the gene sequence of a selenium-containing enzyme (GPx-1) determine how the enzyme interacts with selenium and its effectiveness in protecting cells from DNA damage that could lead to mutations and eventually result in cancer. The experiments plan on indicating the amount of dietary selenium certain individuals or subpopulations need for the greatest cancer-protective benefits. | Illinois | Illinois | Anita Jerome-Morais, PhD | Multiple Sites | selenium, glutathione peroxidase-1, GPx-1 polymorphisms, DNA damage | |||
| GPx-1 Polymorphisms, Selenium and Cancer (2010) | This cell study is examining the hypothesis that individual differences in the gene sequence of a selenium-containing enzyme (GPx-1) determine how the enzyme interacts with selenium and its effectiveness in protecting cells from DNA damage that could lead to mutations and eventually result in cancer. The experiments plan on indicating the amount of dietary selenium certain individuals or subpopulations need for the greatest cancer-protective benefits. | Illinois | Illinois | United States | Anita 0 Jerome-Morais, Ph.D. | Multiple Sites | selenium, glutathione peroxidase-1, GPx-1 polymorphisms, DNA damage | ||
| Gluthathione and Dietary Modulation in Colon Cancer Treatment (1990) | Dr. Chen evaluated whether consumption of broccoli and cabbage might increase the level of glutathione in colon tissue. She also tested whether glutathione might enhance colon tumor cell killings by 5-FU (5-fluorouracil) and thereby possibly improve the effectiveness of 5-FU treatment of colon cancer. | Florida | Florida | Marianne F Chen, ScD | Colon/Rectum | broccoli, cabbage, glutathione, 5-FU | Broccoli & Cruciferous Vegetables | ||
| Glutamine Metabolism in the Tumor-Bearing Rat: Impact of Glutamine Nutrition (1992) | Dr. Souba examined whether consumption of dietary glutamine by rats with either methylcholanthrene-induced fibrosarcoma or metastasizing mammary carcinoma, replenishes glutamine stores to muscle tissue and helps maintain body weight. | Florida | Florida | Wiley W Souba, MD, ScD, PhD | Breast | glutamine | |||
| Glucocorticoid Mediation of Cancer Prevention by Dietary Energy Restriction (1995) | Dr. Birt examined the possible role of cell hormones and their receptor molecules, corticosterone and glucocorticoid receptor (GR), in mice skin to learn how dietary restriction lowers the response to chemical carcinogens. | Nebraska | Nebraska | Diane F Birt, PhD | Skin | corticosterone, glucocorticoid receptor (GR) | |||
| Glucocorticoid Mediation of Cancer Prevention by Dietary Energy Restriction (1997) | Dr. Birt investigated the relationship between glucocorticoids and energy restriction (dietary restriction) in the suppression of skin tumor promotion in mice. | Iowa | Iowa | Diane F Birt, PhD | Skin | glucocorticoids, energy restriction | |||
| Genotoxicity of Dietary Amines in the Pancreas (1994) | Dr. Lawson has shown that heterocyclic amines, formed by pyrolysis of foods high in protein and fat as well as by smoking tobacco, are mutagenic and carcinogenic in several animal systems. Mutagenicity was particularly significant in pancreatic cell studies. He further investigated these heterocyclic amines to determine their potential to induce pancreatic cancer. | Nebraska | Nebraska | Terence A Lawson, PhD | Pancreas | herterocyclic amines, fat | |||
| Genistein: Prevention of advanced prostate cancer in transgenic mice (2000) | Using a transgenic mouse model of prostate cancer, Dr. Elgavish explored whether genistein from soy stimulates apoptosis, or whether it inhibits expression of proteins involved in metastatic spread of prostate tumor cells to bone. | Alabama | Alabama | Ada Elgavish, PhD | Prostate | Genistein | |||
| Genetics and Diet in Prostate Cancer Initiation and Progression (2006) | This study tested the premise that both dietary fat and genetic background infuence risk for prostate cancer. | District of Columbia | District of Columbia | Christopher Albanese, PhD | Prostate | genetics, dietary fat | |||
| Genetic Susceptibility and Dietary Factors in the Etiology of Ovarian Cancer (1991) | Dr. Hulka investigated whether an inherited defect in the transferase enzyme that lowers the ability of the body to properly metabolize galactose, a sugar, might be associated with an increased risk for cancer of the ovaries. | North Carolina | North Carolina | Barbara S Hulka, MD | Ovary | transferase enzyme, galactose | |||
| Genetic Interactions in Vitamin D and Colorectal Cancer in African Americans (2009) | Dr. Ellis investigated whether the higher rate of colorectal cancer among African Americans may be due in part to genetic factors that influence their bodies� production of vitamin D. | Illinois | Illinois | Nathan A Ellis, MD | Colon/Rectum | African Americans, vitamin D insufficiency, sun exposure, skin pigmentation | |||
| Gene-Environment Interaction in Heterocyclic Amine Carcinogenesis (1995) | Dr. Wargovich investigated how dietary fat and fiber can interact with the genetic background of an animal in the activation or deactivation of a dietary carcinogen formed at very low levels by high temperature cooking of protein-rich foods. | Texas | Texas | Michael J Wargovich, PhD | Colon/Rectum | fiber, carcinogens, protein-rich foods | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Garlic Constituents in Treatment of Human Prostate Cancer (2001) | Dr. Verma examined the effect of various garlic compounds on growth, apoptosis and related factors in a human prostate cancer cell line implanted in mice. | Wisconsin | Wisconsin | Ajit K Verma, PhD | Prostate | garlic, apoptosis | |||
| Galactose Consumption and Metabolism in Familial Ovarian Cancer Risk (1990) | Dr. Cramer investigated the possible link between an increased risk for developing ovarian cancer in the mothers and sisters of women with ovarian cancer and a deficiency of a key enzyme (a transferase) needed to metabolize galactose (a sugar) in milk. | Massachusetts | Massachusetts | Daniel W Cramer, MD, ScD | Ovary | a transferase, milk | |||
| Galactose Consumption and Metabolism and Breast Cancer (1994) | Dr. Cramer has demonstrated that postmenopausal women with a history of ovarian cancer exhibit a two-fold increase in the likelihood of expressing a variant galactose transferase (GALT), galactose metabolizing enzyme. Since both breast and ovarian cancers may have a common endocrinologic etiology, Dr. Cramer sought to identify why breast and ovarian cancer share common risk factors and determine the potential of a screening program for women with GALT abnormalities or abnormal hormonal profiles. | Massachusetts | Massachusetts | Daniel W Cramer, MD, ScD | Breast | galactose transferase, galactose metabolizing enzyme | |||
| FRESH START Diet and Exercise Trial among Cancer Survivors: Assessing the Impact on Serum Markers Associated with Progressive Disease & Co-morbidity (2005) | This study investigated blood biomarkers in the participants of the Fresh Start Diet and Exercise intervention program that is ongoing among cancer patients, and determined the extent to which the program leads to alteration in lipid profles, insulin, IGF levels and cytokine profles. | North Carolina | North Carolina | Wendy Demark-Wahnefried, PhD, RD | Other | Fresh Start Diet and Exercise intervention program, blood biomarkers, cancer patients and survivors | |||
| Folate-retinoid Interactions: Implications for Cancer Development (2000) | Dr. Schalinske investigated the means by which retinoids may influence the metabolism of methyl groups and lipotropes. | Iowa | Iowa | Kevin L Schalinske, PhD | Other | retinoids, methyl groups, lipotropes | |||
| Folate, DNA Repair and Cancer (2003) | Dr. Heydari examined whether folate deficiency interacts with genetic factors to increase susceptibility to colon and liver cancers by environmental carcinogens. | Michigan | Michigan | Ahmad R Heydari, PhD | Colon/Rectum, Liver | folate, liver | Legumes (Dry Beans, Peas & Lentils) | ||
| Folate Status: Modulation of Early and Late Molecular Events in Colonic Carcinogenesis (1996) | Dr. Mason investigated the genes in rats affected by low levels of dietary folate to determine the molecular events that may lead to colon cancer and then applied the technique to study molecular changes in colonic polyps from patients on dietary trials of folate. | Massachusetts | Massachusetts | Joel B Mason, MD | Colon/Rectum | folate, molecular changes | Legumes (Dry Beans, Peas & Lentils) | ||
| Folate Status and the Development of Chemically-Induced Mammary Tumors (1997) | Dr. Wilson studied the role of dietary folate in mammary carcinogenesis in rats and whether interactions with pesticide residues have an effect on the processes of carcinogenesis. | Nevada | Nevada | David S Wilson, PhD | Breast | pesticide residues | Legumes (Dry Beans, Peas & Lentils) | ||
| Folate Deficiency; 5, 10-Methylenetetrahydrofolate Reductase (MTHFR) Gene Polymorphism, and Molecular Pathways in Colorectal Carcinogenesis (2002) | Dr. Soliman examined the relationship between a genetic alteration in an enzyme system, dietary factors and age in a unique population of colon cancer patients who do not eat a typical Western sytle diet. | Texas | Texas | Amr Soliman, MD, PhD | Colon/Rectum | folate deficiency, age, non-Western diet | Legumes (Dry Beans, Peas & Lentils) | ||
| Folate and Related Micronutrients, Folate Metabolising Genes and Risk of Barrett's Esophasus and Esophageal Cancer (2006) | This research explored the relationship between low folate intake and the risk of Barrett�s esophagus, a precancerous condition. | Australia | Australia | Penelope M Webb, PhD | Esophagus | folate deficiency, Barrett's esophagus | Legumes (Dry Beans, Peas & Lentils) | ||
| Flaxseed/omega-3 Fatty Acid Chemoprevention for Ovarian Cancer (2006) | This study examined if flaxseed-derived omega-3 fatty acids and/or lignans protect against an avian model of ovarian cancer using the laying hen model that mimics human ovarian cancer. | Illinois | Illinois | Dale B Hales, PhD | Ovary | flaxseed, omega 3, lignans | Flaxseed, Legumes (Dry Beans, Peas & Lentils) | ||
| Flavonoids and Ethnic Differences in Cancer Risk (1997) | Dr. Wolff is evaluated whether the generally lower breast cancer rate in Hispanic women is due to higher intake of flavonoid-containing foods, based on comparisons of food intake in different racial and ethnic groups. | New York | New York | Mary S Wolff, PhD | Breast | flavonoids, Hispanics, ethnic differences | |||
| Fish Oil and Pectin Enhances Apoptosis in Colonocytes via Inhibition of PGE2 and PPAR Delta Signaling and Promotion of Death Receptor Pathway (2005) | This postdoctoral award was used to study how a diet with fish oil and pectin enhances the die-off of precancerous cells in the colon in animal models. | Texas | Texas | Jairam Vanamala, PhD | Colon/Rectum | fish oil, pectin, apoptosis | |||
| ffects of walnut consumption in cancer and cardiometabolic diseas (2012) | Dr. Mantzoros recently found that walnut consumption decreased the growth of colon cancer in mice. By looking at how habitual walnut consumption effects microRNA, small molecules that regulate gene expression, his new study will help us gain a more advanced understanding of these underlying mechanisms. | Massachusetts | Massachusetts | Christos Mantzoros, MD, DSc | Colon/Rectum | ||||
| ffects of Fish Oil on Lipid Metabolites in Breast Cance (2012) | By studying women who were recently diagnosed with invasive breast cancer, Dr. Edwards hopes to determine whether fish oil protects against breast cancer and if so, how it does so. She proposes that omega-3 fatty acids may be safe and inexpensive tools in the arsenal of agents to combat breast cancer. | North Carolina | North Carolina | Iris Edwards, PhD | Breast | ||||
| ffect of vegetable intake on heterocyclic amine metabolism in human (2013) | Dr. Trudo is studying whether eating carrots, broccoli and other plant foods after eating grilled hamburger meat reduces the levels of harmful heterocyclic amines (HCAs) formed by grilled meat. | Minnesota | Minnesota | Sabrina Trudo, PhD | Colon/Rectum | ||||
| ffect of maternal B vitamin intake on tumorigenesis in offsprin (2011) | Dr. Crott is examining how maternal diet affects the risk of colorectal cancer in offspring. He hypothesizes that maternal diets deficient in B vitamins promote cancer but diets supplemented with B vitamins are protective. | Massachusetts | Massachusetts | Jimmy Crott, PhD | Colon/Rectum | Folic Acid, Vitamin B12, Vitamin B2, Vitamin B6 | |||
| Feverfew, an herbal NF-kappaB inhibitor, in the treatment of breast cancer (2000) | Dr. Nakshratri investigated whether daily intake of parthenolide, the active constituent of the herb feverfew, can suppress breast cancer metastasis in a nude mouse breast cancer model and increase the response to taxol, used in treatment of breast cancer. | Indiana | Indiana | Harikrishna Nakshatri, PhD | Breast | parthenolide, feverfew, taxol | |||
| Fatty Acids, Proteoglycans and Breast Cancer (2005) | This study examined the role of membrane proteoglycans in regulation of cell proliferation and apoptosis, and how dietary omega-3 fatty acids through alteration of proteoglycan metabolism can prevent or slow the growth of breast cancer. | North Carolina | North Carolina | Iris J Edwards, PhD | Breast | omega 3, proteoglycan metabolism | |||
| Fatty Acids, Proteoglycans and Breast Cancer (2001) | Dr. Edwards sought to determine whether changes in the fat composition of low density lipoproteins due to feeding rats diets of different polyunsaturated fats can lead to metabolic changes that may affect metastasis of breast cancer cells. | North Carolina | North Carolina | Iris J Edwards, PhD | Breast | lipoproteins, proteoglycan metabolism | |||
| Fatty Acids, Mitochrondia and Molecular Genetics of Colon Cancer (1994) | Dr. Augenlicht continued his investigations on the molecular mechanisms by which dietary fibers reduce the risk for development of colon cancer. He observed that short chain fatty acids (SCFAs) produced by bacteria from dietary fiber in the colon alter the expression of several mitochondrial genes in colonic epithelial cells. Dr. Augenlicht sought determine how two of the major genetic alterations occurring in colonic carcinomas (APC gene and DCC gene) respond to the natural inducers of differentiation, SCFAs and in particular, butyrate. | New York | New York | Leonard H Augenlicht, PhD | Colon/Rectum | fiber, short chain fatty acids, APC gene, DCC gene | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Fatty Acids, Mitochondria, and Molecular Genetics of Colon Cancer (1992) | Dr. Augenlicht studied how degradation products of fiber might modify the pattern of mitochondrial gene expression and thereby protect against colorectal cancer especially when it is linked to familial adenomatous polyposis and hereditary nonpolyposis colon cancer. | New York | New York | Leonard H Augenlicht, PhD | Colon/Rectum | fiber, familial adenomatous polyposis, hereditary nonpolyposis | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Fatty Acid Synthesis as a Novel Chemotherapeutic Target: Therapeutic Consequences of Dietary Fatty Acids (1994) | Dr. Kuhajda explored the role of endogenous fatty acid synthesis in malignant and non-malignant cells, as well as the relationship of dietary fatty acids in the regulation of cell proliferation. He also tested the differential ability of dietary fatty acids to inhibit cell proliferation in normal and cancer cells. | Maryland | Maryland | Francis P Kuhajda, MD | Other | Legumes (Dry Beans, Peas & Lentils) | |||
| Fat-Fiber Interactions: Effect on Colonic Cytokinetics (1991) | Dr. Lupton tested different combinations of fats and fibers in the diet to determine which amounts and types would yield the lowest colon tumor incidence. | Texas | Texas | Joanne R Lupton, PhD | Colon/Rectum | fats, cytokinetics | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Factors Determining the Apoptotic Response of Colorectal Carcinoma Cells to Butyrate, a Fermentation Product Derived from Dietary Fiber (2009) | Studies that examine the effects of dietary fiber and its degradation product, butyrate, on the risk of colon cancer have resulted in conflicting findings. Butyrate causes programmed cell death of colon cancer cells by increasing levels of Wnt signaling. However, some colon cancer cells develop resistance to butyrate. This study examined the mechanisms of the Wnt signaling pathway by using cells that resist the apoptotic effects of butyrate. An understanding of how malignant cells in the colon evade the apoptotic effects of butyrate will help explain the role of dietary fiber and butyrate in colon cancer. | Pennsylvania | Pennsylvania | Michael Bordonaro, PhD | Colon/Rectum | butyrate | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Factors Affecting Nitrosoproline Formation in Vivo (1989) | Dr. Mirvish evaluated whether a test for nitrosoproline in urine might reliably identify people at increased risk for cancer of the esophagus and stomach. He also sought to determine whether increased ascorbic acid and vegetables in the diet might protect against this risk. | Nebraska | Nebraska | Sidney S Mirvish, PhD | Stomach | nitrosoproline, ascorbic acid, vegetables, esophagus | Cranberries, Squash | ||
| Exposure to Divalent Heavy Metals in Fish and Tobacco, Biomarkers of Susceptibility and Risk of Renal Cell Cancer (2008) | The study evaluated the role of blood levels of heavy metals and any relationship to renal cell carcinoma, genetic variability, oxidative stress, vitamin D levels and dietary fsh, using data from the Alpha Tocopherol Beta Carotene cohort, in a nested-case control approach. | Pennsylvania | Pennsylvania | Robin T Wilson, PhD | Kidney | heavy metals, renal cell carcinoma, oxidative stress, vitamin D, dietary fish, cohort study | |||
| Exercise, Energy Restriction, Weight Control and Breast Cancer Prevention (2004) | The goal of this study was to determine the effects of moderate calorie restriction, alone and in combination with moderate or high intensity exercise on mammary gland carcinogenesis in the rat. | Colorado | Colorado | Henry J Thompson, PhD | Breast | caloric restriction | |||
| Exercise and Quercetin in Colon Cancer: Role of Macrophages" (2010) | Evidence suggests that both physical activity and quercetin reduce some types of inflammation related to colorectal cancer. This animal study is examining the independent and combined effects of physical activity and quercetin on the progression of colorectal cancer and whether these effects result from a reduction in macrophage-induced inflammation. | South Carolina | South Carolina | Elizabeth Angela Murphy, PhD | Colon/Rectum | physical activity, nutrition, inflammation, macrophage | Blueberries | ||
| Exercise and Pancreatic Cancer (1988) | Dr. Roebuck studied how exercise, either voluntary or involuntary, combined with a high-fat or a low-fat diet can affect the development of pancreatic cancer. | New Hampshire | New Hampshire | Bill D Roebuck, PhD | Pancreas | high-fat diet, low-fat diet | |||
| Examination of the Green Tea Catechin, EGCG, as a Novel Therapy for Bone Metastases (2004) | This study investigated the ability of the green tea catechin, (-)-epigallocatechin-3-gallate (EGCG), to prevent the metastasis of breast cancer cells to the bone. | Australia | Australia | John T Price, PhD | Breast | green tea, EGCG, metastasis | |||
| Evaluation of the In Vivo Antitumor and Chemosensitizing Activities of Vitamin C and K3 Combinations (1997) | Dr. Jamison studied the effect of combinations of vitamins C and K3, along with vincristine treatment, in suppressing tumor growth and causing cell death in androgen independent prostate cancer cells, as carried in nude mice. | Ohio | Ohio | James M Jamison, PhD | Prostate | vitamin K3, vincristine treatment | Cranberries | ||
| Evaluation of the Antitumor Actions of Vitamin E Compounds In Vitro and In Vivo (2005) | This study investigated the effect different forms of vitamin E have as inhibitors of the growth of breast cancer cells in culture or in animals. | Texas | Texas | Weiping Yu, PhD, MD | Breast | vitamin E | |||
| Evaluation of Edible Mushroom Phytochemicals on Aromatase Activity and Breast Cancer Cell Proliferation (1999) | Dr. Chen investigated whether an extract of edible mushrooms can inhibit aromatase activity in different cellular systems, and thus suppress biosynthesis of excess estrogen, which is implicated as a factor in breast cancer. | California | California | Shiuan Chen, PhD | Breast | mushroom, estrogen, aromatase | |||
| Estrogen-Mediated Prevention of Spontaneous Cell Tumorogenesis in SWR Mice: a Genetic Model for the Mechanistic Exploration of Steroids as Epigenetic Modifiers of Ovarian Tumor Development (2001) | Dr. Beamer used phytoestrogens from soy to try to prevent ovarian tumors in a mouse model. | Maine | Maine | Wesley G Beamer, PhD | Ovary | phytoestrogens, soy | |||
| Esophageal Cancer: Effects of Riboflavin (1986) | Dr. Newberne studied how a deficiency of riboflavin (vitamin B2) might increase the risk of developing esophageal cancer. | Massachusetts | Massachusetts | Paul M Newberne, DVM, PhD | Esophagus | riboflavin | |||
| Epigenetics of Genistein and/or Soy Isoflavone in Breast Cancer Prevention (2009) | Dr. Li studied how the soy component genistein affects the functioning of various genes associated with breast cancer. | Alabama | Alabama | Yuanyuan Li, MD, PhD | Breast | Genistein, soy | |||
| Epigenetics of Breast Cancer and Modulation by Bioactive Compounds (2010) | This laboratory study is testing the hypothesis that dioxins and polycyclic aromatic hydrocarbons (PAHs) cause silencing of the tumor suppressor gene BRCA-1, and natural dietary compounds may prevent some of these mechanisms. Experiments include a series of molecular approaches to study modifications associated with the BRCA-1 gene in order to prevent the onset of sporadic breast cancers linked to silencing of the BRCA-1 gene. | Arizona | Arizona | Donato Romagnolo, PhD | Breast | BRCA1, epigenetics, nutrition | |||
| Epigenetic Effects of Genistein That May Prevent Later Cancer Development (2007) | This study investigated how maternal diet, fortifed with methyl donors and phytoestrogens, changes the onset and severity of adult disease. The goal of the study was to determine how genistein and methyl-supplemented diets methylate and thereby silence many gene promoters, whose expression otherwise results in cancer development and progression. An animal model with pre- and post-implantation of mouse embryos from dams on various diets was used. | Missouri | Missouri | Cheryl S Rosenfeld, DVM, PhD | Other | maternal diet, methyl donors, phytoestrogens, genisten | |||
| Epigallocatechin-3-gallate for Enhancement of Cisplatin Therapy (2006) | This study determined whether EGCG, a major component of green tea, sensitises ovarian cancer cells to cisplatin treatment by inhibiting detoxifcation of cisplatin through inactivation of AP-1 and NF-?B pathways that could lead to the depletion of glutathione. | Pennsylvania | Pennsylvania | Marion M Chan, PhD | Ovary | green tea, EGCG, cisplatin, AP-1, NF-?B, glutathione | |||
| Enhancement of the Response of Breast Tumor Cells to Fractioned Radiation by Ananlogs of Vitamin D3 (2002) | Dr. Gewirtz studied the mechanism by which vitamin D analogs and radiation cause some human breast cancer cells in culture to die out, either through the action of the cell signaling molecule ceramide, or through mutations in the p53 gene. | Virginia | Virginia | David A Gewirtz, PhD | Breast | vitamin D3, p53 gene, ceramide | |||
| Enhancement of Doxorubicin Therapy via Protecting Against Chronic Heart Failure by a Unique Nutraceutical (2009) | Dr. Li tested whether a substance found in cruciferous plants can make a common chemotherapy drug less damaging to the hearts of cancer patients. | Virginia | Virginia | Yunbo Li, MD, PhD | Other | doxorubicin therapy, cruciferous plants, chronic heart failure | Broccoli & Cruciferous Vegetables | ||
| enetic, Dietary and Environmental Influences on Vitamin D Metabolis (2012) | Although there is not yet conclusive evidence linking vitamin D to cancer prevention, the inconsistent results may be due to how individuals metabolize vitamin D. Her new study is investigating genetic differences in vitamin D metabolism. | Pennsylvania | Pennsylvania | Robin Wilson, PhD | Breast, Colon/Rectum, Lung | ||||
| Energy Intake and the Early Stages of Breast Cancer Progression (1996) | Dr. Christman explored the relationship between a restricted diet (60% of control) and a high fat diet (40% of calories from fat) on the conversion of benign breast lesions to a cancerous state in mice, as well as the hormonal status of the host mice, the balance between cell proliferation and apoptosis, and the influence of estrogen and estrogen receptors on the interaction between the different regimens. | Nebraska | Nebraska | Judith K Christman, PhD | Breast | restricted diet, high-fat diet, apoptosis, estrogen | |||
| Efficacy of Vitamin D in Advanced Prostate Cancer: a Pilot Study (1995) | Dr. VanVeldhuizen sought to determine whether treatment with vitamin D and analogs can moderate the pain associated with advanced prostatic cancer, either by correcting vitamin deficiency, by having an antiproliferative effect on the cancer, or by alleviating the effects of oncogenic osteomalacia. | Missouri | Missouri | Peter J Van Veldhuizen, MD | Prostate | vitamin deficiency, oncogenic osteomalacia | |||
| Effects of Vitamin A on Simple Human Epithelial Cells (1988) | Dr. Fuchs studied how vitamin A can prevent the development of cancer by determining how, at the genetic level, vitamin A affects the differentiation and proliferation of normal and pre-cancerous human epithelial cells. | Illinois | Illinois | Elaine V Fuchs, PhD | Other | genetics, epithelial cells | |||
| Effects of Selenium on Chemically-Altered Cells During Hepatocarcinogenesis (1984) | Dr. Faris studied how selenium affects a group of pre-cancerous liver cells. Preliminary data suggested that selenium may be a tumor promoter and it may depend on when the selenium is administered in these liver cells to determine if it acts as a promoter or inhibitor of cancer. | Rhode Island | Rhode Island | Ronald A Faris, PhD | Liver | selenium | |||
| Effects of Selenium and Vitamin E in Prevention of Retrovirus Induced Immune Suppression and Cancer (1987) | Dr. Kline sought to determine whether vitamin E and the mineral selenium can prevent the development of cancer caused by a retrovirus and if these nutrients bolster the immune system, modulate retrovirus-induced immunosuppression, or inhibit the process of carcinogenesis. | Texas | Texas | Kimberly Kline, PhD | Other | Vitamin E, selenium, retrovirus | |||
| Effects of Pomegranate Juice on Hormonal Biomarkers of Breast Cancer Risk (2010) | Certain sex hormones in the body, especially estrogens, play an important role in the development of breast cancer. This investigation is examining if a daily glass of pomegranate juice alters the sex hormone levels in blood and breast fluid of postmenopausal women. | Massachusetts | Massachusetts | Susan Sturgeon, DrPH | Breast | pomegranate juice, serum hormones, nipple aspirate fluid, postmenopausal women | |||
| Effects of Organic Sulfides on the Metabolism of Nitrosamines (1990) | Dr. Yang continued his studies to determine how diallyl sulfide (DAS) and other sulfur compounds from alliums (garlic, onions, and related vegetables) might influence specific enzymes and thereby prevent their activation of carcinogens that cause colon cancer. | New Jersey | New Jersey | Chung S Yang, PhD | Colon/Rectum | diallyl sulfide, alliums, enzymes | Squash | ||
| Effects of Organic Sulfides on the Metabolism of Nitrosamines (1988) | Dr. Yang investigated whether certain sulfur-containing compounds found in garlic and onions can interfere with the metabolic activation of carcinogens. | New Jersey | New Jersey | Chung S Yang, PhD | Other | garlic, onions, sulfur | |||
| Effects of LLSO and LLHOSO on the Progression of Breast Cancer (2007) | This study examined the effects of low linolenic soy oil and low linolenic high oleic soy oil on transformation of a premalignant human breast cancer cell line in vitro and in vivo as xenografts. The oils are low in trans fatty acids and in addition to their benefcial effects in cardiovascular disease, could also be benefcial in prevention and growth of breast cancer. | Virginia | Virginia | Young H Ju, PhD | Breast | low linolenic soy oil, low linolenic high oleic soy oil | Legumes (Dry Beans, Peas & Lentils) | ||
| Effects of Isoflavones on Human Breast Cancer Cells in Culture (1991) | Dr. Barnes sought to identify the isoflavones and their mechanisms of action that inhibit breast cancer development. Isoflavones are estrogen-like substances present in soybeans. | Alabama | Alabama | Stephen Barnes, PhD | Breast | Soybean isoflavones | |||
| Effects of Instant Green or Black Tea on Mammary Carcinogenesis (1992) | Dr. Sakamoto evaluated whether polyphenols in green and black tea, which are from the same plant but produced by different processes, might be effective inhibitors of breast cancer in rats. She sought to determine at which stage(s) in carcinogenesis this protection occurs. | Pennsylvania | Pennsylvania | Kazuko Sakamoto, PhD | Breast | green tea, black tea, polyphenols | |||
| Effects of Folic Acid Metabolism on DNA Repair (2002) | Dr. Branda studied whether dietary folate deficiency can lead to incorporation of the wrong constituents into cells, eventually leading to neoplastic disease. | Vermont | Vermont | Richard F Branda, MD | Other | folate deficiency, neoplastic disease | Legumes (Dry Beans, Peas & Lentils) | ||
| Effects of Folic Acid Deficiency on Metastatic Potential (1985) | Dr. Branda examined how a deficiency of folic acid, a B-vitamin, may increase the likelihood that skin cancer will metastasize, or spread to other tissues in the body. | Vermont | Vermont | Richard F Branda, MD | Skin | metastasis, folic acid deficiency | |||
| Effects of Folate and the Folate Receptor on Ovarian and Endometrial Cancer: an In Vitro Study (2006) | The objective of this research was to elucidate the roles of folate and folate receptor alphain in ovarian and endometrial cancers. It investigated the expression and localization of the receptor in clinical samples and in ovarian and endometrial cancer cell lines and examined the effects of folate on proliferation, apoptosis, migration and invasion of normal and cancer cell lines in vitro. | Hong Kong | Hong Kong | Michelle Kwan-Yee Siu, PhD | Endometrium, Ovary | folate, folate alphain, ovarian and endometrial cancer, apoptosis | Legumes (Dry Beans, Peas & Lentils) | ||
| Effects of Essential Amino Acid Intake on Net Protein Synthesis in Weight-losing Non-small Cell Lung Cancer Patients (2009) | Weight loss commonly occurs in non-small lung cancer patients, negatively influencing their quality of life, treatment response, and survival. Loss of muscle protein is generally a central component of weight loss in cancer patients. Anorexia, due to metabolic alterations in cancer, leads to reduced food intake. This study examines the acute effects of a nutritional essential amino supplement on net protein synthesis in non-small lung cancer patients with weight loss. | Arkansas | Arkansas | Marielle Engelen, PhD | Lung | amino acids, anorexia | |||
| Effects of Dietary Potassium on Colorectal Cancer (1989) | Dr. Thompson studied changes in the colonic transport of the mineral potassium that may be associated with development of colon cancer, and how these changes, as well as the development of colon cancer, are affected by potassium in the diet. | California | California | Stephen M Thompson, PhD | Colon/Rectum | potassium | |||
| Effects of Dietary Polyunsaturated Fats on Helicobacter Pylori (1997) | Dr. Smoot sought to determine whether the number of bacteria in the stomach, as measured by an antibody test, is related to dietary polyunsaturated fat levels, or whether the fats affect bacterial growth in culture. | District of Columbia | District of Columbia | Duane T Smoot, MD | Stomach | dietary polyunsaturated fats | |||
| Effects of Dietary Isoflavonoids on Prostate Cancer Proliferation and Tumorigenesis (1999) | Dr. Shiverick investigated whether dietary isoflavonoids from soy have any inhibitory effect on androgen-sensitive and androgen-independent prostatic carcinoma cells, both in culture and in nude mouse xenografts, in addition to studying the mechanism of growth inhibition by the isoflavones. | Florida | Florida | Kathleen T Shiverick, PhD | Prostate | dietary isoflavonoids, soy | |||
| Effects of Dietary Folic Acid Modulation Upon Development of Bronchogenic Carcinoma (1993) | Dr. Hammond studied the effects of both a folate-deficient diet and folate-excessive diet on the four stages of development of bronchogenic carcinoma: carcinogen-induced transformation, progression, development and manifestation of metastasis. | California | California | William G Hammond, MD | Lung | folate deficiency, folate-excessive diet | Legumes (Dry Beans, Peas & Lentils) | ||
| Effects of Dietary Fish Oil on Correlates of Human Colon Cancer (1988) | Dr. Knapp explored the possibility that the consumption of fish oil supplements may change the bacterial environment of the colon and the subsequent metabolism of compounds thought to be involved in the development of colon cancer. | Tennessee | Tennessee | Howard R Knapp, MD, PhD | Colon/Rectum | fish oil | Legumes (Dry Beans, Peas & Lentils) | ||
| Effects of Dietary and Nutritional Factors on Esophageal Carcinogenesis (1986) | Dr. Yang studied if certain substances found in corn, wheat and other foods bind with the minerals calcium, zinc, or magnesium in the cells of the esophagus, and thus make cancer more likely to develop. | New Jersey | New Jersey | Chung S Yang, PhD | Esophagus | corn, wheat, calcium, zinc, magnesium | |||
| Effects of Copper Intake on DMH Induced Carcinogenesis (1990) | Dr. DiSilvestro sought to determine whether a deficiency in copper in the diet might be responsible for an increased risk for colon cancer. He assessed whether changes in the activities of special enzymes that require copper to function might be linked to changes in colon cancer incidences. | Ohio | Ohio | Robert A DiSilvestro, PhD | Colon/Rectum | copper deficiency | |||
| Effects of Copper Intake on Chemcial Carcinogenesis (1993) | In preliminary studies, Dr. DiSilvestro found that rats with low copper intake had increased carcinogenesis over rats fed normal amounts of copper. He examined the hypothesis that varying levels of copper, specifically deficient versus normal amounts, act as a possible promoter for cancer. He tested a variety of carcinogens and looked at the effects in a breast cancer model. | Ohio | Ohio | Robert A DiSilvestro, PhD | Breast | copper, carcinogens | |||
| Effects of Chemotherapeutic Isoprenoids on the Mevalonate Pathway (1999) | Dr. Crowell hypothesized that dietary isoprenoids such as geraniol or farnesol may exert antitumor effects in pancreatic tumor models through modulation of the mevalonate pathway in tumor cells, and thus depress the proteins that increase tumor cell growth. | Indiana | Indiana | Pamela L Crowell, PhD | Pancreas | dietary isoprenoids, geraniol, farnesol, mevalonate pathway | |||
| Effects of Caloric Restriction on Rat Testicular Tumor Formation (1992) | Dr. Gandy investigated whether the reduction in spontaneous testicular tumors in rats by caloric restriction may be associated with changes in activation and detoxification of enzymes or steroid hormones. This was a collaborative study supported by AICR and the Food and Drug Administration�s National Center for Toxicological Research. | Arkansas | Arkansas | Jay Gandy, PhD | Testis | caloric restriction | |||
| Effects of Brassica or Indole-3-carbinol in Prostectomy Patients with PSA Recurrence (2004) | A randomized, placebo-controlled, double-blinded pilot trial was conducted, comparing the effects of Brassica consumption and indole-3-carbinol supplements on PSA among prostate cancer patients with PSA recurrence following prostectomy. | Tennessee | Tennessee | Jay H Fowke, PhD, MPH | Prostate | brassica, indole-3-carbinol, PSA recurrence | |||
| Effects of Adenoviral Gene Transfer of C.elegans n-3 Fatty Acid Desaturase on Lipid Profile and Growth of Human Cancer Cells (2002) | Dr. Kang investigated whether introducing a gene encoding an n-3 fatty acid desaturase into human tumor cells in culture would decrease the levels of more undesirable n-6 polyunsaturated fatty acids and increase n-3 fatty acids, thus providing an anticancer effect. | Massachusetts | Massachusetts | Jing X Kang, MD, PhD | Multiple Sites | n-3 fatty acid desaturase, n-6 polyunsaturated fatty acids | |||
| Effectiveness of a Combination of Inhibitors on Chemical Carcinogenesis (1983) | Dr. Slaga explored which combinations of anti-cancer substances, including vitamins C, E, and the mineral selenium, are most effective in interfering with the different stages in the development of skin cancer. | Texas | Texas | Thomas J Slaga, PhD | Skin | vitamin E, selenium | |||
| Effect of Zinc Replenishment on Cell Proliferation and Esophageal Carcinogenesis in Zinc Deficient Rats (1993) | In many areas of the world, the high rates of esophageal cancer are associated with vitamin and mineral deficiencies rather than tobacco and alcohol uses as in the United States. Dr. Fong studied the role of dietary zinc deficiency in esophageal cancer, in hopes of answering two questions: 1) is zinc deficiency reversible; and 2) does zinc prevent development of esophageal tumors in a carcinogen-induced (N-methylbenzylnitrosamine) model. | Pennsylvania | Pennsylvania | Louise Y Fong, PhD | Esophagus | zinc deficiency | Cherries | ||
| Effect of Wheat Class and Processing on Colon Cancer Prevention (2001) | Dr. Gallaher examined the effect that the type of wheat flour and its processing have on colon cancer in a rat model. | Minnesota | Minnesota | Daniel D Gallaher, PhD | Colon/Rectum | wheat flour | |||
| Effect of Vitamin D on Breast Cancer Metastasis (1998) | Dr. Welsh tested the hypothesis that activation of cell death (apoptosis) by vitamin D and/or its analogs causes regression of breast cancer, inhibits local invasion and retards the metastic spread of estrogen-independent breast cancer in a mouse model. | Indiana | Indiana | JoEllen Welsh, PhD | Breast | apoptosis | |||
| Effect of Various Nutrients on Macrophage Activation (1986) | Dr. Everse tested if a certain group of chemicals found in food helps to stimulate the immune system to attack cancer cells. | Texas | Texas | Johannes Everse, PhD | Other | nutrients, macrophage activation | |||
| Effect of the Dietary Compound Queuine on the Incidence and Type of Neoplasms of Germfree Mice (1989) | Dr. Farkas explored the possibility that a little known substance in food called queuine could be important to the body�s defense against cancer. | Tennessee | Tennessee | Walter R Farkas, PhD | Other | queuine | |||
| Effect of Soy Isoflavone Consumption on Plasma Hormones Related to Prostate Cancer Risk in Healthy Young Men (2001) | Dr. Duncan sought to determine whether there is any relationship between soy isoflavones in the diet and hormone levels in healthy young men. | Canada | Canada | Alison M Duncan, PhD, RD | Prostate | soy isoflavones | |||
| Effect of Soluble Fibers on Colonic Physiology (1989) | Dr. Lupton studied how soluble dietary fiber, the kind found in oat bran and beans, seems to both increase the risk of developing colon cancer as well as reduce the chances of developing coronary heart disease. | Texas | Texas | Joanne R Lupton, PhD | Colon/Rectum | soluble dietary fiber, oat bran, beans, coronary heart disease | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Effect of Short-Chain Fatty Acids on the APC-modulated B-catenin-Tcf transcription pathway in colonic carcinoma cells. (1997) | Dr. Bordonaro examined whether the short chain fatty acid, butyrate, induces cell death in colon carcinoma cells by a mechanism involving a cellular protein complex. | New York | New York | Michael Bordonaro, PhD | Colon/Rectum | butyrate | |||
| Effect of Selenium on Imunocompetent Cell Function (1986) | Dr. Kiremidjian-Schumacher is studied whether modulation of the selenium content of the diet can affect the function of immunocompetent cells and, therefore, significantly modify the relationship between tumor and host. | New York | New York | Lidia Kiremidjian-Schumacher, PhD | Other | selenium | |||
| Effect of Phenolic Antioxidants on Cell Cycle Regulatory Genes (2001) | Dr. Narayanan used normal and prostate cancer cells to identify the genes responsive to the dietary antioxidants resveratrol and ellagic acid to pinpoint the hormonal, regulatory and mechanistic aspects of the cellular response. | New York | New York | Bhagavathi Narayanan, PhD | Prostate | resveratrol, ellagic acid | Blueberries | ||
| Effect of Ornithine Alpha-Ketoglutarate on Protein Metabolism in Tumor-bearing Animals (1991) | Dr. Baracos studied how the drug ornithine alpha-ketoglutarate (OKG) might improve the absorption and use of nutrients and thereby protect against malnutrition and weight loss in animals with liver cancer. | Canada | Canada | Vickie E Baracos, PhD | Liver | ornithine alpha-ketoglutarate, malnutrition, weight loss | |||
| Effect of Mevinolin and Limonene on CT-26 Hepatic "Metastasis" in BALB/c Mice (1993) | Dr. Broitman examined how limonene and a drug mevacor (mevinolin), which inhibits production of cholesterol in the liver, alter the functioning of a specific oncogene, ras-oncogene, and affect colon cancer development. | Massachusetts | Massachusetts | Selwyn A Broitman, PhD | Colon/Rectum | limonene, mevacor, cholesterol | Legumes (Dry Beans, Peas & Lentils), Grapefruit | ||
| Effect of Inositol Hexaphosphate on the Growth of Transplantable Fibrosarcoma in Mice (1991) | Dr. Vucenik sought to determine how inositol, a component of dietary fiber, might regulate the natural immune defense by increasing natural killer cells and thereby retarding the growth of tumors. | Maryland | Maryland | Ivana Vucenik, PhD | Other | inositol | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Effect of Inositol Hexaphosphate on Mammary Carcinogenesis (1992) | Dr. Vucenik studied the dose-response inhibition of DMBA-induced mammary carcinogenesis in vivo by dietary inositol hexaphosphate (phytic acid), a component of cereals, and the effect of phytic acid on the growth and metastasis of human breast carcinoma in vitro. This study was supported by a Matching Grant from AICR and Kellogg Company. | Maryland | Maryland | Ivana Vucenik, PhD | Breast | phytic acid | Legumes (Dry Beans, Peas & Lentils) | ||
| Effect of Inositol Compounds on Mammary Carcinogenesis (1992) | Dr. Vucenik evaluated the absorption and inhibitory effect of dietary inositol hexaphosphate (phytic acid), a component of cereals, on tumor cell proliferation in a DMBA-induced mammary cancer model. | Maryland | Maryland | Ivana Vucenik, PhD | Breast | phytic acid | Legumes (Dry Beans, Peas & Lentils) | ||
| Effect of Green Tea Components on Breast Cancer Signalling (1997) | Dr. Cobrinik tested whether epigallocatechin gallate from green tea interferes with tyrosine kinase signaling pathways, using a human mammary cell model. | New York | New York | David E Cobrinik, MD, PhD | Breast | EGCG, great tea, tyrosine kinase signaling pathway | |||
| Effect of Glutamine-Supplemented Nutrition on Gastrointestinal Toxicity of 5-Fluorouracil and Tumor Growth (1987) | Dr. Smith explored the possibility that some of the intestinal side effects caused by chemotherapy can be prevented by supplying patients with extra amounts of the amino acid glutamine, which the gastrointestinal tract appears to use more rapidly during severe stress. | Massachusetts | Massachusetts | Robert J Smith, MD | Colon/Rectum | glutamine | |||
| Effect of Folate and Methyl Deficiency on DNA Methyltransferases and Methylated DNA Binding Proteins (2001) | Dr. Miller examined the effects of diets deficient in folate and methyl groups on proteins and nucleic acids involved in cellular processes requiring methylation reactions. | California | California | Joshua W Miller, PhD | Liver | folate, methyl | Legumes (Dry Beans, Peas & Lentils) | ||
| Effect of Fatty Acid Supplementation on Oncogene-induced Cell Transformation (1987) | Dr. Weinstein studied how dietary fatty acids can affect the transformation of healthy cells into cancerous ones, by examining the biochemical and molecular changes that follow the introduction of these fatty acids into cells which have been isolated from rats and altered with cancer-causing genes called oncogenes. | New York | New York | I. Bernard Weinstein, MD | Bladder | fatty acids, oncogenes | |||
| Effect of Enteral Formulas on Methotrexate Toxicity (1991) | Dr. Archuleta investigated whether soy protein diets might protect the intestinal tract against the toxicity of methotrexate, a chemotherapeutic drug, thereby allowing more effective treatment with this drug. | Utah | Utah | Martha Archuleta, PhD, RD | Colon/Rectum | soy protein diet, methotrexate | |||
| Effect of EGCG, a Phytochemical from Green Tea, on Integrin Activation and Cancer Cell Metastasis (2009) | Dr. Kim studied a compound found in green tea for its ability to interfere with a process cancer cells use to spread to other parts of the body. | California | California | Chungho Kim, PhD | Other | EGCG, green tea | |||
| Effect of Dietary Protein Quantity and Source on Anti-tumor Immunity in the Rat (1992) | Dr. Dietert studied the effects of different types of protein (casein from milk, vegetable protein from soy and wheat) in varying amounts on anti-tumor immunity to aflatoxin-induced carcinogenesis. | New York | New York | Rodney R Dietert, PhD | Liver | casein, soy, wheat, protein, aflatoxin | |||
| Effect of Dietary Omega-3 Fatty Acid on P53 Tumor Suppressor Gene (1992) | Dr. Ronai investigated how high-fat diets may affect p53 gene regulation and breast cancer cell growth. | New York | New York | Zeev Ronai, PhD | Breast | high-fat diet, p53 gene regulation, omega-3 | |||
| Effect of Dietary Lipid on Transplantable Colon Carcinoma (1985) | Dr. Broitman studied, in mice, the relationships between the transplant locations of colonic tumors and their response to dietary factors and the specific effects of cholesterol on the growth and spread of colon cancer. | Massachusetts | Massachusetts | Selwyn A Broitman, PhD | Colon/Rectum | cholesterol | Legumes (Dry Beans, Peas & Lentils) | ||
| Effect of Dietary Fat Source on Phospholipase C Gamma 1 Activation in Early Stage Colon Carcinogenesis (1996) | Dr. Jiang studied the molecular mechanism of dietary n-3 polyunsaturated fatty acids (PUFA�s) for their protective effect against experimental colon carcinogenesis. | Texas | Texas | Yi Hai Jiang, PhD | Colon/Rectum | n-3 fatty acids, PUFAs | |||
| Effect of Dietary Fat on Mammary Tumorigenesis (1986) | Dr. Abraham studied how polyunsaturated fat in the diet affects the transformation of normal breast cells into pre-cancerous cells and the subsequent transformation of these cells into breast tumors. | California | California | Sandy Abraham, PhD | Breast | polyunsaturated fat | |||
| Effect of Dietary Estrogens on the Development of Liver Cancer (2007) | The purpose of this postdoctoral project was to study the chemopreventive effect of natural phytoestrogens and estradiol against liver carcinogenesis induced by diethylnitrosamine in male mice and to study whether Jun kinase activity is involved. | California | California | Christian Kuntzen, MD | Liver | dietary estrogen | |||
| Effect of Dietary Ellagic Acid on Transplacental Carcinogenicity: Pilot Study (1994) | Dr. Frank investigated the potential of maternal dietary ellagic acid, a naturally occurring plant phenolic, to provide chemoprevention in utero against chemical carcinogens and subsequently reduce early childhood cancers. | Colorado | Colorado | Anthony A Frank, DVM, PhD | Other | maternal dietary ellagic acid, childhood cancers | Blueberries | ||
| Effect of Dietary Antioxidants on Genetic Instability and Cancer Incidence in Ataxia Telangiectasia (2004) | This study examined whether antioxidants from grapes, including resveratrol, can reduce the development of cancer at multiple sites in mice that are models of Ataxia Telangiectasia. | California | California | Robert H Schiestl, PhD | Blood/Bone Marrow/Lymph | Ataxia Telangiectasia, grapes, resveratrol | Blueberries | ||
| Effect of Dietary Anticarcinogenesis on Hepatic Cytochrome P-450 Mixed-Function Oxidase Enzymes in the Chicken Embryo (1989) | Dr. Goeger explored the possibility that chick embryos can be used to study how certain substances in our food help to prevent cancer, a technique which could lead to their substitution for laboratory rats and mice in certain experiments which benefit humans. | Texas | Texas | Douglas E Goeger, PhD | Other | chicken embryo, mixed-function oxidase embryo | |||
| Effect of Carotenoids on Mammary and Urinary Bladder Cancers (1987) | Dr. Grubbs investigated whether three carotenoids found in fruits and vegetables can prevent the initiation or promotion of breast or bladder cancer. | Alabama | Alabama | Clinton J Grubbs, PhD | Bladder, Breast | Carotenoids | Squash, Cherries | ||
| Effect of Cancer on Nutrient Metabolism in the Liver (1988) | Dr. Liu explored how cancer affects the liver�s metabolism of carbohydrate and fat, in order to learn more about why nutrients are used inefficiently during cancer. | Illinois | Illinois | Katherine J Liu, MD | Other | carbohydrate, metabolism | |||
| Effect of Caloric Restriction on Endogeous Retrovirus Expression and Lymphoma Development in Aged Rodents (1992) | Dr. Blank investigated if caloric restriction may delay the expression of a retrovirus that is associated with lymphomas, and if the delay in viral expression also delays the development of lymphoma in mice. This was a collaborative study supported by AICR and the Food and Drug Administration�s National Center for Toxicological Research. | Pennsylvania | Pennsylvania | Kenneth J Blank, PhD | Blood/Bone Marrow/Lymph | caloric restriction, endogeous retrovirus, lymphoma | |||
| Effect of Caloric Restriction on DNA Binding and DNA Adduct Removal In Vivo (1992) | Dr. Chung investigated whether the reduction in genotoxicity of polycyclic aromatic hydrocarbons by caloric restriction might be due to a decrease in DNA adduct formation or an increase in adduct removal from the liver of carcinogen-treated mice. This was a collaborative study supported by AICR and the Food and Drug Administration�s National Center for Toxicological Research. | Tennessee | Tennessee | King-Thom Chung, PhD | Liver | caloric restriction, polycyclic aromatic hydrocarbons, adducts | |||
| Effect of Bile Acids on Colonic Signal Transduction Mechanisms (1996) | Dr. Ceryak investigated the role of bile acids in the modulation of signal transduction pathways thought to be involved in colon carcinogenesis. | District of Columbia | District of Columbia | Susan Ceryak, PhD | Colon/Rectum | bile acids | |||
| Effect of Antioxidant Vitamins on Radioimmunotherapy-Induced Normal Tissue Toxicity (1999) | The objective of Dr. Blumenthal�s research was to delineate which combinations of vitamins, especially A, E, and C, will afford the most protection to liver, kidney, intestines and bone marrow against radiation from radioactive antibody therapy for cancer. | New Jersey | New Jersey | Rosalyn D Blumenthal, PhD | Colon/Rectum | vitamin A, vitamin E, vitamin C | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Grapefruit, Squash | ||
| Effect of Age on Colon Cancer Inhibition by Curcumin (2000) | Dr. Magnuson invesitgated the effect of age on the response of rats to a carcinogen, using various biomarkers as a measure of effect. | Maryland | Maryland | Bernadene Magnuson, PhD | Colon/Rectum | Curcumin | |||
| Effect of a Lifestyle Intervention on Body Weight, Psychological Health Status & Risk Factors Associated with Disease Recurrence in Women Recovering from Breast Cancer Treatment (2005) | The aim of this study was to evaluate the effect of dietary and physical activity intervention on body weight and psychological well-being in women recovering from breast cancer. | United Kingdom | United Kingdom | John M Saxton, PhD | Breast | intervention study, breast cancer survivors | |||
| Effect of a Chemopreventive Diet on Carcinogen-Induced Colonic Ras Activation (1997) | Dr. Chapkin compared the effects of various polyunsaturated fatty acids in the activation of a gene product which is implicated as part of the system that modulates the early stages of colon cancer development. | Texas | Texas | Robert S Chapkin, PhD | Colon/Rectum | Ras activation | |||
| EB 1089/vitamin D3 and Radiation in Breast Tumor Cells (2006) | This study used the combination of the active form of vitamin D and its analog with radiation to improve the treatment of breast cancer and prevent tumor regrowth due to the generation of reactive oxygen species. | Virginia | Virginia | David A Gewirtz, PhD | Breast | vitamin D3, ratiation treatment, reactive oxygen species | |||
| Dysregulated Mitosis: A New Chemopreventive Mechanism for Curcumin (1999) | Dr. Sacks investigated the effects of the spice curcumin on specific growth factors in human oral cavity cells to determine whether curcumin causes atypical cells to die rather than continue growing. | New York | New York | Peter G Sacks, PhD | Head and Neck | curcumin | |||
| Dual Effects of Soy to Treat Prostate Cancer: Inhibition of Prostaglandins and Enhancement of the Anti-proliferative Activity of Vitamin D (2006) | This study explored whether soy enhances the anticancer activity of vitamin D and calcitriol against prostate cancer through inhibition of 24-hydroxylase (CYP24) and prostaglandins by suppressing expression of COX-2 in a mouse xenograft model. | California | California | David Feldman, MD | Prostate | soy, calcitriol, CYP24 | |||
| Does Vitamin D Status Modulate Colon Cancer Driven by APC Allele Loss? (2009) | Dr. Fleet tested how a wide range of vitamin D levels influence risk for colon cancer. | Indiana | Indiana | James C Fleet, PhD | Colon/Rectum | APC allele | |||
| Does TNF-Alpha Blockade Prevent Wasting in Lung Cancer (2003) | Dr. Jatoi studied the effects of the drug inflixamib on lung cancer patients to determine if the treatments improve weight, appetite, quality of life, and survival by preventing the anorexia/cachexia syndrome. | Minnesota | Minnesota | Aminah Jatoi, MD | Lung | inflixambi | |||
| Does Iron Deficiency and/or Iron Overload Play a Role in Breast Cancer? (1993) | Dr. Sherman studied the effects of iron deficiency or abundance on mammary tumor development and the mammary cell cycle. She sought to answer the following questions: 1) is tumorigenesis altered by either; 2) does modification after carcinogen exposure influence tumor development; and 3) does deficiency impair mammary cell cycle and decrease tumorigenesis? | New Jersey | New Jersey | Adria R Sherman, PhD | Breast | iron deficiency/abundance | Legumes (Dry Beans, Peas & Lentils) | ||
| Does Dietary Folate Intake Modify Treatment-related Toxicity or Disease Outcome Among Children with Acute Lymphoblastic Leukemia? (2009) | Dr. Kelly investigated the role dietary folate may play in the effectiveness and side effects of an anti-folate chemotherapy drug both during and after treatment. | New York | New York | Kara Kelly, MD | Blood/Bone Marrow/Lymph | acute lymphoblastic leukemia, children, chemotherapy side effects, methotrexate | Legumes (Dry Beans, Peas & Lentils) | ||
| Docosahexaenoic Acid, and Omega-3 Fatty Acid, Inhibits Macrophage Tumoricidal Activity (1988) | Dr. Lu examined how a polyunsaturated fatty acid found in fish oil interferes with the functioning of macrophages, which are part of the body�s immune defense against cancer. | Texas | Texas | Christopher Y Lu, MD | Other | fish oil, omega-3, macrophages | |||
| Do Components of a Chinese Diet (Genistein, Green Tea, and Phytate) Inhibit Prostate Cancer? (1995) | Dr. Pretlow investigated whether components of the Chinese diet, genistein present in soy and green tea, and phytate present in rice, prevent the promotion and progression of the initiated prostate cells. These studies aimed to clarify the role of dietary components in the prevention of latent, early prostate cancer from developing into a clinically significant disease. | Ohio | Ohio | Theresa P Pretlow, PhD | Prostate | Chinese diet, genistein, soy, green tea, phytate, rice | |||
| Direct Inhibitory Effect of Garcinol on FAK-Mediated Cancer Cell Survival (2006) | This postdoctoral study examined the effect of Garcinol, a polyisoprenylated benzophenone found in the Guttiferae, to inhibit focal adhesion kinase (FAK) activation, in order to understand the FAK-related downstream signalling pathways and the mechanisms of Garcinol on apoptosis in cancer cells. | New York | New York | Adam Kisailus, PhD | Other | garcinol, guttiferae, focal adhesion kinase activation | |||
| Diindolylmethane Improves Effectiveness of Paclitaxel for Breast Cancer Treatment (2006) | This study investigated the potential of diindolylmethane (DIM), a dietary component in cruciferous vegetables, to enhance the cytotoxic effects of paclitaxel in human breast cancer cells. | Pennsylvania | Pennsylvania | Susan Lanza-Jacoby, PhD | Breast | diindolylmethane,cruciferous vegetables, cytotoxic effects of paclitaxel | Broccoli & Cruciferous Vegetables, Squash | ||
| Differential Gene Regulation in Normal and Transformed Keratinocytes by 1,25 (OH)2 D3 and Retinoic Acid (2003) | Dr. Bikle used keratinocytes in culture to investigate how the development of squamous cell carcinomas can be inhibited by derivatives of vitamin D [ 1,25(OH)2D] and vitamin A [retinoic acid]. | California | California | Daniel D Bikle, MD, PhD | Skin | Vitamin D, vitamin A, squamous cell carcinoma, keratinocytes | |||
| Differential Gene Regulation in Normal and Transformed Keratinocytes by 1,25 (OH) 2D3 and Retinoic Acid (1998) | Dr. Bikle investigated the mechanism underlying the differential responses of normal human keratinocytes and squamous carcinoma cells to treatment with vitamin D3 and retinoic acid, based on the concept that transcriptional intermediary factors are involved in the different responses. | California | California | Daniel D Bikle, MD, PhD | Skin | retinoic acid, vitamin D3, squamous cell carcinoma, keratinocytes | |||
| Differential Effect of Nutrients on Colonic Epithelium with Different Acquired Genotypes (1996) | Dr. Costa investigated the association between the potentially protective role of calcium and olive oil (a source of monounsaturated fatty acids) consumption against chemically-induced colon cancer and the genetic background of the cells. | Connecticut | Connecticut | Jose Costa, MD | Colon/Rectum | calcium, olive oil, monounsaturated fatty acids | |||
| Dietary-Component Inhibition of Mutagenesis in Transgenic Mice (1995) | Dr. Guttenplan used a special mouse model to determine whether antioxidant vitamins and other chemoprotective substances (phytochemicals) found in foods can affect the beginning or the later course of carcinogenesis from environmental carcinogens found in tobacco smoke and other products of combustion. | New York | New York | Joseph B Guttenplan, PhD | Breast, Lung, Liver | phytochemicals, tobacco | Legumes (Dry Beans, Peas & Lentils) | ||
| Dietary Treatment for the Prevention of Cervix Dysplasias (1987) | Dr. Romney sought to determine if a nutrient supplement of beta-carotene, vitamin C, and folic acid administered for six months, in amounts exceeding normal requirements, can slow down or reverse the growth of pre-cancerous cells in women diagnosed with moderate cervical dysplasia. | New York | New York | Seymour L Romney, MD | Cervix | beta-carotene, vitamin C, cervical dysplasia | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Grapefruit, Squash | ||
| Dietary Sphingolipids and Inhibitors of Sphingolipid Metabolism: Role in Cancer (1998) | Dr. Goldkorn sought to determine the effects of fumonisms, toxic compounds produced by molds sometimes found in foods, on the processes of cell growth and death in animal cells, and studying enzyme systems which may mediate the effects of the toxins. | California | California | Tzipora Goldkorn, PhD | Other | fumonisms, sphingolipids | |||
| Dietary Selenium, Mammary Tumorigenesis and Biologic Mechanisms in Rats Fed Protein-Fat Enriched Diet (1984) | Dr. Hawrylewicz sought to determine whether the addition of the mineral selenium to a high protein diet would prevent the development of breast cancer. | Illinois | Illinois | Ervin J Hawrylewicz, PhD | Breast | selenium | |||
| Dietary Restrictions, Meal Anticipation, and Mammary Tumor Formation (2005) | This study investigated whether the anticipation of a meal is part of the protective effect of restricted diets against cancer in animal systems. | Ohio | Ohio | Deborah Clegg, PhD, RD | Breast | meal anticpation, dietary restrictions | |||
| Dietary Promotion of HBV-Induced Liver Tumors (1993) | Dr. Campbell�s hypothesis was that chronic infection with the Hepatitis B virus coupled with nutritional factors, especially those associated with an increase in plasma cholesterol, stimulates liver cell proliferation and results in liver cancer. He tested whether dietary protein, specifically casein that is a strong modulator of cholesterol, will modify the development of tumor formation in the liver. | New York | New York | T. Colin Campbell, PhD | Liver | Hepatitis B, plasma cholesterol, casein | Legumes (Dry Beans, Peas & Lentils) | ||
| Dietary Patterns and Breast Density (2000) | Dr. Tseng investigated whether there is any correlation between dietary intake and breast density in a group of women at high risk of breast or ovarian cancer. | Pennsylvania | Pennsylvania | Marilyn Tseng, PhD | Breast | dietary intake, breast density, ovarian cancer | |||
| Dietary Oxidants and Antioxidants, Oxygen Radical Damage, and Carcinogenesis in Human Subjects (1990) | Dr. Campbell sought to determine whether antioxidants in foods can protect against damage to DNA, the genetic material, and thus lower cancer risk. The studies were carried out on people living in the People�s Republic of China. Antioxidants in foods they eat were measured, as well as markers for DNA damage in blood and urine. The antioxidant and marker levels were correlated with the cancer rates in the Chinese. | New York | New York | T. Colin Campbell, PhD | Multiple Sites | China, antioxidants, DNA damage | |||
| Dietary Omega-3 Fatty Acids and Cancer (1992) | Dr. Wan investigated how dietary fat in the form of omega-3 fatty acids from fish oil might alter the immune response and prostaglandin metabolism, influence the rate of tissue protein synthesis, and inhibit the growth of breast cancer cells. | Massachusetts | Massachusetts | Jennifer Wan, PhD | Breast | omega-3, fish oil, prostaglandin metabolism | |||
| Dietary Obesity and Prostate Cancer Development in TRAMP Mice (2006) | This study examined the infuence of obesity and leptin on prostate cancer induction and development in a mouse model. | Minnesota | Minnesota | Margot P Cleary, PhD | Prostate | obesity, leptin | |||
| Dietary Modulation of Intestinal Tumorigenesis (2005) | This study investigated whether a Western-style diet supplemented with calcium and vitamin D or selenium can inhibit tumor formation in a new mouse genetic model (Muc2-/-, p21) that accelerates the development of colon tumor formation. | New York | New York | WanCai Yang, MD | Colon/Rectum | Selenium, calcium, vitamin D | |||
| Dietary Modification of the Effects of Carcinogens on Gene Expression and DNA Methylation (1986) | Dr. Wainfan explored the effect some carcinogens have on the body�s supply of methyl groups, a chemical necessary for the orderly reproduction and functioning of cells, and whether this effect can be counteracted by the diet. | New York | New York | Elsie Wainfan, PhD | Liver | carcinogens, methyl groups | |||
| Dietary Modification of Mammary Carcinogenesis (1984) | Dr. Carroll sought to determine if reducing the level of fat in the diet of older laboratory animals already exposed to carcinogens can prevent the subsequent appearance of breast cancer. | Canada | Canada | Kenneth K Carroll, PhD | Breast | carcinogens | |||
| Dietary Manipulation of Primary and Secondary Neoplasms of Liver (1983) | Dr. Brada previously observed that adding the amino acid methionine to the diet slows down the development of a certain type of liver cancer. This study sought to determine if this effect is also true for other types of cancer. | Florida | Florida | Zbynek Brada, PhD | Liver | methionine | |||
| Dietary Manipulation of Glucose and Glutamine to Challenge Brain Tumor Metabolism (2010) | Brain tumors cells have a constant hunger for glucose and a need for glutamine, an amino acid produced by the body and also consumed in the diet. The study is using a specialized technique to track dietary substances consumed by animals as they are taken up by the brain tumor and processed for energy and growth. | Connecticut | Connecticut | Henk De Feyter, PhD | Nervous System | glucose, glutamine | |||
| Dietary Manipulation of Glucose and Glutamine to Challenge Brain Tumor Metabolism (2010) | Brain tumors cells have a constant hunger for glucose and a need for glutamine, an amino acid produced by the body and also consumed in the diet. The study is using a specialized technique to track dietary substances consumed by animals as they are taken up by the brain tumor and processed for energy and growth. | Connecticut | Connecticut | Henk De Feyter, PhD | Nervous System | glucose, glutamine | |||
| Dietary Manipulation of Glucose and Glutamine to Challenge Brain Tumor Metabolism (2010) | Brain tumors cells have a constant hunger for glucose and a need for glutamine, an amino acid produced by the body and also consumed in the diet. The study is using a specialized technique to track dietary substances consumed by animals as they are taken up by the brain tumor and processed for energy and growth. | Connecticut | Connecticut | United States | Henk 0 De Feyter, Ph.D. | Nervous System | glucose, glutamine | ||
| Dietary Manipulation of Glucose and Glutamine to Challenge Brain Tumor Metabolism (2010) | Brain tumors cells have a constant hunger for glucose and a need for glutamine, an amino acid produced by the body and also consumed in the diet. The study is using a specialized technique to track dietary substances consumed by animals as they are taken up by the brain tumor and processed for energy and growth. | Connecticut | Connecticut | Henk De Feyter, PhD | Nervous System | glucose, glutamine | |||
| Dietary Lipids and Proliferative Signaling Through p21 ras Proteins (1994) | Dr. Golubic has demonstrated that some nutritionally relevant fatty acids might activate the cellular p21 ras (c-ras) proteins and promote cancer development. In this study he investigated the possibility that the tumor-enhancing effects of omega-6 polyunsaturated fatty acids and the tumor inhibitory effects of omega-3 polyunsaturated fatty acids may be a consequence of the differential regulation of two important proteins (GAP and neurofibromin) which regulate c-ras. | Ohio | Ohio | Mladen Golubic, MD, PhD | Other | p21 ras (c-ras) proteins, omega-3 and omega-6 polyunsaturated fatty acids | |||
| Dietary Lipids and Hormones in Breast Carcinogenesis (2005) | This study tested whether dietary lipids and retinoids differentially promote interaction of PPAR/ RXR heterodimers with their coactivator proteins to regulate proliferation of normal human breast epithelial cells and breast cancer cell lines. The goal of this study was to provide insight into the roles of dietary fat and fat soluble hormones in prevention of breast cancer. | California | California | David L Crowe, PhD | Breast | PPAR/RXR, retinoids | |||
| Dietary Lipids and Hormones in Breast Carcinogenesis (2001) | Dr. Crowe examined how certain fats and retinoids can affect the growth of breast cancer cells and whether these compounds also prevent the disease from occurring in the first place. | California | California | David L Crowe, PhD | Breast | retinoids | |||
| Dietary Lipids Alter Colonic Lymphocytes to Increase Tumorigenesis (1998) | Dr. Kuratko tried to delineate the role of the inflammatory response in colon carcinogenesis, specifically the role that n-3 fatty acids play in suppressing this type of response. | Texas | Texas | Connye N Kuratko, PhD | Colon/Rectum | n-3 fatty acids, inflammation | |||
| Dietary Lipid Effects on Expression of Manganese Superoxide Dismutase During Colon Carcinogenesis (1996) | Dr. Kuratko studied the effect of various types and levels of lipids on expression of a tumor suppressing gene (the manganese superoxide dismutase enzyme) both in a normal rat intestinal cell line and in chemically-induced colon tumors in rats. | Texas | Texas | Connye N Kuratko, PhD | Colon/Rectum | lipids, manganese superoxide dismutase enzyme | |||
| Dietary Lipid as a Factor in Progression of Preneoplastic Mammary Cells to Tumor Formulation (1985) | Dr. Hosick explored the possibility that certain dietary fats increase the risk of developing breast cancer because their consumption leads to changes in a body�s adipose tissue that stimulates nearby pre-cancerous cells to become cancerous. | Washington | Washington | Howard L Hosick, PhD | Breast | adipose tissue | |||
| Dietary Isothiocyanates, Glutathione S-transferases, and Colorectal Neoplasia (1999) | Dr. Martinez investigated whether eating cruciferous vegetables, which naturally contain isothiocyanates, will decrease the risk from recurrence of new adenomas in patients who recently had colonic adenomas removed. | Arizona | Arizona | Maria E Martinez, PhD | Colon/Rectum | cruciferous vegetables, isothiocyanates, colorectal adenoma | Broccoli & Cruciferous Vegetables, Squash | ||
| Dietary Intake of Choline and Betaine, Related Genetic Polymorphisms, and the Risk of Colorectal Cancer (2009) | Dr. Lim studied the intake of two nutrients among a large multiethnic population to determine if genetic factors play a role in the susceptibility to cancers that are linked to nutrient deficiencies. | Hawaii | Hawaii | Unhee Lim, PhD | Colon/Rectum | choline, betaine, cohort study, nutrient deficiencies | |||
| Dietary Inhibition of Cyclooxygenase-2 Gene Expression: A Novel Approach to Cancer Prevention (1999) | Dr. Dannenberg tried to delineate the means by which dietary rosemary and its major components, carnosol and ursolic acid, inhibit the expression of the gene for COX 2, an enzyme involved in the oxidative activation of some carcinogens. | New York | New York | Andrew J Dannenberg, MD | Colon/Rectum | rosemary, carnosol, ursolic acid, COX2 | Cranberries | ||
| Dietary Inhibition of Cyclooxgenase as a Chemopreventive Strategy for Upper Aerodigestive System Cancer (1996) | Dr. Sacks examined the effects of various dietary compounds such as curcumin and retinoic acid, on the expression of an activating enzyme, cyclooxygenase, in both normal and premalignant human oral cells in culture. | New York | New York | Peter G Sacks, PhD | Head and Neck | curcumin, retinoic acid, cyclooxygenase | Legumes (Dry Beans, Peas & Lentils) | ||
| Dietary Influences on Reversal of Changes in DNA Methylation and Expression of Protooncogenes and Suppressor Genes Induced by Short-term Lipotrope Deficiency (1992) | Dr. Christman investigated how diets that are deficient in lipotropes, folic acid, vitamin B12, choline, and methionine, might increase the susceptibility to cancer-causing agents and enhance liver cancer. Her studies focused on hypomethylation of selected oncogenes. | Michigan | Michigan | Judith K Christman, PhD | Liver | lipotropes, folic acid, vitamin B12, choline, methionine, oncogenes | |||
| Dietary Influences on Reversal of Changes in DNA Methylation and Expression of Protooncogenes and Suppressor Genes Induced by Short Term Lipotrope Deficiency (1994) | Dr. Christman continued her investigations of dietary lipotropes (vitamin B12, folic acid, choline and methionine) in cancer. She has shown that a deficiency of these compounds interferes with the normal transfer of methyl groups to the genetic material (DNA) of cells. By studying this phenomena in genes that are important regulators of growth and cell differentiation, she sought to provide insight into mechanisms by which dietary factors can enhance their susceptibility or resistance to carcinogenic stimuli, e.g. environmental carcinogens. | Nebraska | Nebraska | Judith K Christman, PhD | Liver | vitamin B12, folic acid, choline, methionine | Legumes (Dry Beans, Peas & Lentils) | ||
| Dietary Influence on UVR-Induced Melanoma (1990) | Dr. Ley sought to determine whether different amounts of fat in the diet might influence our risk for getting melanoma, a form of skin cancer. The skin cancer was induced in a South American opossum by exposure to UV rays from sunlight. | New Mexico | New Mexico | Ronald D Ley, PhD | Skin | melanoma | |||
| Dietary Induction of Nucleotide Imbalance and Promotion of Carcinogenesis (1985) | Dr. Lea studied if a compound found in milk, called orotic acid, can, in high concentrations, promote the development of kidney cancer by interfering with the normal synthesis of DNA. In addition, the possibility that a diet deficient in arginine, an essential amino acid, might act in a similar fashion was investigated. | New Jersey | New Jersey | Michael A Lea, PhD | Kidney | orotic acid, milk, arginine | |||
| Dietary Induced Sporadic Colon Cancer (2009) | Much colon cancer is linked to consumption of diets that subtly alter the normal balance of the colonic mucosa and elevate the probability of a tumor forming over a long period of time. This study used a novel mouse model to examine the mechanism by which the Wnt signaling pathway is altered by nutritional factors present in a western diet (high in fat and low calcium, vitamin D, choline, methionine, folate and fiber). | New York | New York | Leonard H Augenlicht, PhD | Colon/Rectum | Western diet, high-fat diet, calcium, vitamin D, choline, methionine, folate, fiber | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Dietary Histidine and UV-Induced Skin Cancer (1994) | Dr. De Fabo investigated the role of the dietary amino acid histidine in skin cancer development. Levels of a unique substance, urocanic acid, in the skin appear to be influenced by histidine levels in the diet. Increased urocanic acid levels in turn are associated with increased immune suppression resulting in skin tumors. The study sought to determine whether controlling the dietary intake of histidine will help prevent against skin cancer. | District of Columbia | District of Columbia | Edward C De Fabo, PhD | Skin | histidine, urocanic acid | |||
| Dietary Glucarate-Mediated Inhibition of Mammary Carcinogenesis (1986) | Dr. Walaszek sought to identify plant sources rich in a potent beta-glucuronidase inhibitor, called glucarolactone, or its precursors, glucaric acid and glucarate, to determine if these compounds inhibit the development of breast cancer. | Texas | Texas | Zbigniew Walaszek, PhD | Breast | glucarolactone, glucaric acid, glucarate | |||
| Dietary Genistein and Photocarcinogenesis (2000) | Dr. Wei investigated whether taking a soy supplement in the diet can afford protection against skin damage from ultraviolet irradiation in humans. | New York | New York | Huachen Wei, MD, PhD | Skin | genistein, soy, UV irradiation | |||
| Dietary Genistein and Photocarcinogenesis (1996) | Dr. Wei tested the protective action of genistein, a flavonoid from soybeans, against different phases of UV irradiation-induced skin carcinogenesis in mice. | New York | New York | Huachen Wei, MD, PhD | Skin | genistein, soy, UV irradiation | |||
| Dietary Garlic and Mammary Cancer (1991) | Dr. Milner evaluated how different components of the diet (protein, fat, selenium, and vitamin A) might influence the ability of garlic to inhibit mammary tumor development. | Pennsylvania | Pennsylvania | John A Milner, PhD | Breast | protein, fat, selenium, vitamin A, garlic | |||
| Dietary Garlic and Mammary Cancer (1993) | A water soluble sulfur compound in garlic, s-allylcysteine, inhibits binding of a carcinogen known as DMBA to DNA and decreases the incidence of mammary tumors in an animal model. Dr. Milner continued his investigation in this area by studying the mechanisms of interaction between lipids and garlic and the role it plays in breast cancer development. | Pennsylvania | Pennsylvania | John A Milner, PhD | Breast | garlic, s-allylcysteine, fat | |||
| Dietary Folate Manipulation: Impact on Prostate Tumor Biology, Genetics and Epigenetics (2007) | This study examined how folate status in mammals affects epigenetic events that drive tumorigenesis in prostate epithelium. It aimed to determine if supplementation of folate slows the progression of prostate cancer from a harmless overgrowth to a lethally aggressive cancer, and if folate depletion increases the DNA damage. | New York | New York | Gaia Bistulfi, PhD | Prostate | Folate, DNA damage | Legumes (Dry Beans, Peas & Lentils) | ||
| Dietary Folate Manipulation to Prevent Prostate Cancer Progression (2007) | This study aimed to explore the role of folate in altering the progression of pre-cancerous lesions in men at risk for developing prostate cancer, as well as the progression of tumors in men with disease by modulation of DNA methylation. | Pennsylvania | Pennsylvania | Denise S O'Keefe, PhD | Prostate | folate, DNA methylation | Legumes (Dry Beans, Peas & Lentils) | ||
| Dietary Fish Oil: Effect on Tumor Immunology (1990) | Dr. Jenski examined how omega-3 PUFAs (polyunsaturated fatty acids) from the diet become incorporated into the cell membrane, alter the membrane structure, and change the immune response or ability to kill cancer cells. | Indiana | Indiana | Laura J Jenski, PhD | Other | omega-3-PUFAs, fish oil | |||
| Dietary Fish Oil: Effect on Tumor Immunology (1993) | Dr. Jenski propsed that omega-3 fatty acids found in fish oil will affect the structure of cancer cell membranes and by doing so, will alter the interaction between cancer cells and the immune system. She investigated how diet changes tumor cell composition. If it can be altered, one could purposefully affect and possibly eradicate the tumor through enhanced immunologic attack. | Indiana | Indiana | Laura J Jenski, PhD | Other | omega-3, fish oil | |||
| Dietary Fiber, Bile Acids and Colon Carcinogenesis (1986) | Dr. Story examined how different sources of dietary fiber influence both the amount and type of bile acids that reach the colon and how this may be affected by calcium in the diet. | Indiana | Indiana | Jon A Story, PhD | Colon/Rectum | bile acid, calcium | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Dietary Fatty Acids, Isoflavones and Prostate Cancer (1994) | Dr. Rose investigated the effects of high fat diets, using n-3 and n-6 polyunsaturated fatty acids, on tumor growth and metastasis in two human prostate cancer cell lines. He also investigated whether dietary soy, a source of the antiangiogenic agent genistein, inhibits the establishment of PC-M solid tumors and their metastasis in nude mice. | New York | New York | David P Rose, MD, PhD | Prostate | n-3 and n-6 polyunsaturated fatty acids, metastasis, soy, genistein | |||
| Dietary Factors in Relation to Prostate Cancer Risk and Survival (2009) | Dr. Kasperzyk examined the effect of dietary factors like dairy foods and fish on prostate cancer risk among men in three large, ongoing studies. | Massachusetts | Massachusetts | Julie Kasperzyk, PhD | Prostate | Calcium, dairy products, fish, rye bran, cohort study, Sweden, Iceland | |||
| Dietary Energy Restriction and Estrogen Action in the Rat Mammary Gland (1997) | Using a unique rat model, Dr. Shull investigated whether a diet with 40% fewer calories than usual would inhibit estrogen induction of mammary cancer and affect various parameters of cell proliferation and death. | Nebraska | Nebraska | James D Shull, PhD | Breast | caloric restriction, estrogen | |||
| Dietary Energy Density, Body Size and Biomarkers Related to Cancer Risk" (2010) | This study is using the most recently available national survey nutrition data to determine whether total dietary energy density, and the consumption frequency and amount of high-energy-dense foods contribute to body weight, body fatness, insulin sensitivity (related to diabetes type 2) and inflammation (measured in blood), which are all related to cancer risk. | Pennsylvania | Pennsylvania | Terryl Hartman, PhD | Multiple Sites | energy density, diet, overweight, obesity, insulin sensitivity, inflammation | |||
| Dietary Effects on Gene Expression in Mammary Tumorigenesis (1991) | Dr. Etkind investigated how dietary fat might activate a cancer-causing gene from a virus, in an animal model, and thereby promote the development of breast cancer. | New York | New York | Polly Etkind, PhD | Breast | fat | |||
| Dietary Effects on Gene Expression in Mammary Tumorigenesis (1993) | In her first grant, Dr. Etkind showed that a high fat diet causes increased gene expression and affects the dormancy period of tumor expression in mice. Dr. Etkind observed the mechanism by which this occurs and attempted to answer new questions: 1) at what percentage fat intake does gene expression begin; and 2) is there a specific time in life when fat consumption accelerates breast cancer risk. | New York | New York | Polly Etkind, PhD | Breast | fat intake and consumption | |||
| Dietary DIM in Pancreatic Cancer Prevention and Therapy (2010) | This study is testing the hypothesis that the gene KLF4 plays a critical role in the ability of the dietary compound diindolylmethane (DIM) to prevent and repress tumor activity in pancreatic cancer. Experiments will determine how DIM affects the level and activity of KLF4 in pancreatic cancer cells and in mouse models, and provide information about whether other food components shown to activate KLF4 can be safely used for pancreatic cancer treatment. | Texas | Texas | Daoyan Wei, PhD | Pancreas | Diindolylmethane, KLF4, cancer prevention | |||
| Dietary DIM in Pancreatic Cancer Prevention and Therapy (2010) | This study is testing the hypothesis that the gene KLF4 plays a critical role in the ability of the dietary compound diindolylmethane (DIM) to prevent and repress tumor activity in pancreatic cancer. Experiments will determine how DIM affects the level and activity of KLF4 in pancreatic cancer cells and in mouse models, and provide information about whether other food components shown to activate KLF4 can be safely used for pancreatic cancer treatment. | Texas | Texas | Daoyan Wei, PhD | Pancreas | Diindolylmethane, KLF4, cancer prevention | |||
| Dietary DIM in Pancreatic Cancer Prevention and Therapy (2010) | This study is testing the hypothesis that the gene KLF4 plays a critical role in the ability of the dietary compound diindolylmethane (DIM) to prevent and repress tumor activity in pancreatic cancer. Experiments will determine how DIM affects the level and activity of KLF4 in pancreatic cancer cells and in mouse models, and provide information about whether other food components shown to activate KLF4 can be safely used for pancreatic cancer treatment. | Texas | Texas | United States | Daoyan 0 Wei, Ph.D. | Pancreas | Diindolylmethane, KLF4, cancer prevention | ||
| Dietary DIM in Pancreatic Cancer Prevention and Therapy (2010) | This study is testing the hypothesis that the gene KLF4 plays a critical role in the ability of the dietary compound diindolylmethane (DIM) to prevent and repress tumor activity in pancreatic cancer. Experiments will determine how DIM affects the level and activity of KLF4 in pancreatic cancer cells and in mouse models, and provide information about whether other food components shown to activate KLF4 can be safely used for pancreatic cancer treatment. | Texas | Texas | Daoyan Wei, PhD | Pancreas | Diindolylmethane, KLF4, cancer prevention | |||
| Dietary Control of Gene Expression by the Anti-Cancer Element Selenium (1997) | Dr. Newburger studied the mechanism by which dietary selenium controls gene expression through development of a reporter gene to facilitate following dietary control by selenium. | Massachusetts | Massachusetts | Peter E Newburger, MD | Other | dietary selenium | |||
| Dietary Choline Deficiency: Studies on the Early Events Leading to Hepatocarcinogenesis (1994) | Dr. Zeisel continued his investigations of the mechanism of hepatocarcinogenesis by dietary choline deficiency. He sought to determine if choline-deficient animals will undergo early sensitizing events and later gene damaging events leading to cancer. He also sought to identify other nutrients and drugs which block this process. | North Carolina | North Carolina | Steven H Zeisel, MD, PhD | Liver | choline deficiency, hepatocarcinogenesis | |||
| Dietary Carotenoids and their Metabolites as Cancer Preventive Agents (1998) | Dr. Bertram investigated why beta-carotene has a protective action against cancer in laboratory animal models, but no such effect in clinical trials in humans, perhaps because metabolic products of carotene may be the actual protective agents. | Hawaii | Hawaii | John S Bertram, PhD | Other | beta-carotene | Grapefruit | ||
| Dietary Caloric Regulation of Gene Expression and Mammary Tumorigenesis in Transgenic Mice (1992) | Dr. Sarkar examined how low- and high-calorie diets might differ in their effects on virally mediated oncogene expression and subsequent regulation of mammary tumorigenesis in transgenic mice. | Georgia | Georgia | Nurul H Sarkar, PhD | Breast | caloric regulation | |||
| Dietary Antioxidants, p53 status, and Tumorigenesis in a Wnt-1 mouse Model of Human Breast Cancer (1999) | Dr. Albright examined the opposing roles of dietary antioxidants, such as beta-carotene and tocopherols, versus reactive oxygen species in tumor apoptosis, using a transgenic mouse model that readily develops mammary tumors. | North Carolina | North Carolina | Craig D Albright, PhD | Breast | beta-carotene, tocopherols, reactive oxygen species, apoptosis | Grapefruit | ||
| Dietary Antioxidants and Transplacental Carcinogenesis (1987) | Dr. Yielding sought to determine whether the consumption of antioxidants, such as the vitamins C and E, the mineral selenium, or the food additive BHT, can prevent the development of cancer during the long delay between exposure to a carcinogen and the actual appearance of the tumor. | Texas | Texas | K. Lemone Yielding, MD | Multiple Sites | vitamin C, vitamin E, selenium, BHT, carcinogens | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Grapefruit, Squash | ||
| Dietary Antioxidants and Protein Kinase C Oxidative Activation in Tumor Promotion (1993) | Protein Kinase C (PKC), which plays a role with enzymes to regulate cell growth, is affected by antioxidants. This grant looked at how dietary antioxidants�specifically carotenoids, vitamins C and E, and selenium�affect the activation or inactivation of PKC. The main goal of this study was to understand the nutrient interactions that are effective in counteracting tumor promoters. | California | California | Rayuda Gopalakrishna, PhD | Other | PKC, antioxidants, carotenoids, vitamin C, vitamin E, selenium | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Grapefruit, Squash | ||
| Dietary Antioxidants and Peroxisome Proliferator-Induced Hepatocarcinogenesis (1986) | Dr. Glauert studied whether the development of liver cancer in rats, induced by a hypolipidemic drug, can be prevented by the antioxidants vitamin E or selenium. | Kentucky | Kentucky | Howard P Glauert, PhD | Liver | vitamin E, selenium | |||
| Dietary and Environmental Estrogen Sulfation by Human Cytosolic Sulfotransferases (1995) | The goals of Dr. Falany�s investigations were to determine the ability of a newly identified form of human cytosolic- and other sulfotransferases (STs) to sulfate several synthetic, natural and dietary estrogenic compounds (i.e. estrogen, estradiol, genistein, daidzein, naringenin). The action of these STs may provide possible protection against the development of hormone responsive cancers. | Alabama | Alabama | Charles N Falany, PhD | Breast | Sulfotransferases (STs) | Legumes (Dry Beans, Peas & Lentils) | ||
| Dietary and Chemo-suppression of Human Breast Cancer Progression in Nude Mice (1994) | Dr. Liu developed combinations of dietary and chemo-suppressive therapies for the prevention of micrometastasis in breast cancer patients. The compounds tested include genistein from soy, curcumin, omega-3 fatty acids and a drug, minocyclin. It was expected that the combination therapies would result in having maximum antitumor effects with little or no toxic side-effects. | New York | New York | Xin-Hua Liu, MD, PhD | Breast | genistein, soy, curcumin, omega-3 fatty acids, minocyclin | |||
| Diet, Oxidative DNA Damage and Breast Cancer Risk (1999) | Dr. Thompson sought to determine the urine and blood levels of markers of oxidative stress in groups of women on diets with up to 10 servings/day of certain vegetables and fruits, in comparison with levels in women on diets with 3 servings/day of fruits and vegetables. | Colorado | Colorado | Henry J Thompson, PhD | Breast | oxidative stress, fruits and vegetables | Apples, Squash, Cherries | ||
| Diet, Oxidative DNA Damage and Breast Cancer Risk (1997) | Dr. Thompson measured various markers for DNA damage in women on diets with either 3 or 10 daily servings of fruits and vegetables, based on the hypothesis that fruits and vegetables help decrease DNA damage. | Colorado | Colorado | Henry J Thompson, PhD | Breast | DNA damage, fruits and vegetables | Apples, Squash, Cherries | ||
| Diet, Lipid Peroxidation and Risk of Breast Cancer (1998) | Dr. Boyd sought to correlate the levels of serum and urine levels of markers for cell damage in women on a low-fat breast cancer intervention diet with breast density, as determined by mammography. | Canada | Canada | Norman F Boyd, MD, DSc, FRCPC | Breast | lipid peroxidation, low-fat breast cancer dietary intervention, breast denisty | |||
| Diet, Exercise and Murine Mammary Tumorigenesis (1987) | Dr. Lane investigated whether the reduction in occurrence of breast cancer following a low-calorie or low-fat diet is a result of the diet itself or a result of changes this diet causes on the composition of the body�s tissue. | Alabama | Alabama | Helen W Lane, PhD | Breast | low-calorie diet, low-fat diet, exercise | |||
| Diet, Colonic Bacterial Metabolism and Colon Cancer Risk in African Americans (2002) | Dr. O�Keefe did a comparative study of colonic bacteria versus diet in groups of African Americans, Caucasian Americans and Native Africans to determine whether changes in bacterial populations might contribute to the dietary risk factors for colon cancer. | Virginia | Virginia | Stephen J O'Keefe, MD | Colon/Rectum | colonic bacteria, African Americans, Caucasian Americans, Native Ameriacns, dietary risk factors | |||
| Diet in the Etiology of Stomach Cancer: Case-Control Study in Moscow (1995) | In Russia and other countries of Eastern Europe, there is a very high incidence of gastric cancer. Dr. Zaridze and his colleagues conducted an epidemiological study in ten districts of Moscow to examine the relationship of dietary practices, smoking and alcohol consumption to gastric cancer. | David Zaridze, MD, PhD | Stomach | Russia, dietary practices, smoking, alcohol | |||||
| Diet in Adolescence and the Risk of Breast Cancer (1994) | Dr. Lumey investigated the effect of energy and/or fat restriction during adolescence and puberty and the subsequent breast cancer rates in women who experienced these restrictions compared to women who had not. The project provided an opportunity to compare the long-term effects of energy restriction in humans and its effects on cancer risk and longevity. | New York | New York | L.H. Lumey, MD, PhD | Breast | energy and fat restriction, adolescence, puberty | |||
| Diacylglycerol Accumulation During Choline Deficiency: Mechanism for Hepatic Carcinogenesis (1989) | Dr. Zeisel investigated how choline deficiency enhances liver cancer. He sought to determine if the excess 1,2-sn-diacylglycerol (1,2-DAG) that accumulates in the liver during choline deficiency might activate protein kinase C (PKC) and in this way lead to tumor initiation and promotion. | Massachusetts | Massachusetts | Steven H Zeisel, MD, PhD | Liver | 1,2-sn-diacylglycerol, choline definiency, protein kinase C | |||
| Development of Nutritional Antioxidant-based Strategies to Prevent Etoposide-induced Acute Myeloid Leukemia (1997) | Dr. Kagan examined whether it is possible to reduce development of secondary cancer (acute myeloid leukemia) after treatment with the anticancer drug etoposide through vitamin C and E supplementation. | Pennsylvania | Pennsylvania | Valerian E Kagan, PhD, DSc | Blood/Bone Marrow/Lymph | acute myeloid leukemia | Cranberries | ||
| Detoxification of the Dietary Carcinogen N-hydroxy-PhIP: Variability in Human Colon and Relevance for Colon Cancer (2007) | PhIP is a carcinogen formed from a chemical reaction in meat cooked at high temperature, causing colon cancer in rats through conversion to its hydroxylamine metabolite (NHOH-PhIP). This study examined the cellular mechanism by which NHOH-PhIP can be detoxifed by involvement of cytochrome b5 reductase (b5R) and cytochrome b5 (cyt b5), while single nucleotide polymorphisms (SNPs) account for variability in response. | Wisconsin | Wisconsin | Lauren A Trepanier, PhD, DVM | Colon/Rectum | PhIP, cooked meat, hydroxylamine metabolite | |||
| Determination of Cranberry Constituents with Antiproliferative Activity Against Human Tumor Cell Lines (2003) | Dr. Ferguson sought to identify components of cranberry that are responsible for its observed anticancer activity and to determine the mechanisms underlying the ability of cranberry constituents to inhibit the proliferation of prostate tumor cells and induce cell death. | Canada | Canada | Peter J Ferguson, PhD | Prostate | cranberry extracts | Cranberries | ||
| Determination of Cranberry Constituents with Antiproliferative Activity Against Human Tumor Cell Lines (2001) | Dr. Ferguson examined different types of cranberry extracts to determine which are most active against the growth of cell lines representative of human lung, colon, breast and prostate tumors as well as melanoma. | Canada | Canada | Peter J Ferguson, PhD | Breast, Colon/Rectum, Prostate, Skin | cranberry extracts | Cranberries | ||
| Design and Feasibility of a Mediterranean Diet (2003) | Dr. Djuric developed and tested a dietary exchange list that will help women consuming a typical American Diet to change to a more Greek-Mediterranean diet high in monounsaturated fats and rich in fruits and vegetables that may lower breast cancer risk. | Michigan | Michigan | Zora Djuric, PhD | Breast | Mediterranean diet | Squash, Cherries | ||
| Definition of the Immunologic Contribution of an Omega-3 Fatty Acid Source to Inhibition of UV-Carcinogenesis (1992) | Dr. Black continued his investigation of different types of dietary fat from corn oil and fish oil and their ability to modify UV-carcinogenesis by regulating chemicals that control the natural immune response. | Texas | Texas | Homer S Black, PhD | Skin | omega-3, corn oil, fish oil | |||
| Defined Medium for Human Breast Cells (1984) | Dr. Ham developed a system for growing human breast cells in the laboratory, so that researchers studying breast cancer can experiment with normal human breast epithelial cells maintained under precisely controlled conditions. | Colorado | Colorado | Richard G Ham, PhD | Breast | epithelial cells | |||
| Decreased Retinoid Response in Peroxisome Proliferator Treated Keratinocytes (1997) | Dr. Aneskievich sought to determine whether various fatty acids might act as peroxisome proliferators and interfere with the beneficial effects of retinoids in regulating the growth and differentiation of malignant skin cells. | Connecticut | Connecticut | Brian J Aneskievich, PhD | Skin | fatty acids, retinoids, keratinocytes | Legumes (Dry Beans, Peas & Lentils) | ||
| Cyclic Fluctuations in Food Intake, Body Weight and Mammary Tumorigenesis (1991) | Dr. Tagliaferro studied whether �yo-yo� dieting, alternating between low-and high-calorie diets to manage body weight, increases the development of breast cancer. | New Hampshire | New Hampshire | Anthony R Tagliaferro, PhD | Breast | high-fat diet, low-fat diet | |||
| Cyclic Fluctuations in Food Intake, Body Weight and Mammary Tumorigenesis (1993) | Fat and excess calories have been associated with increased risks for breast cancer while caloric restriction, in animal studies, has been shown to be a potent inhibitor of breast cancer. Dr. Tagliaferro continued his study on whether or not �yo-yo� dieting increases the risk for breast cancer. | New Hampshire | New Hampshire | Anthony R Tagliaferro, PhD | Breast | high-fat diet, low-fat diet | |||
| Curcumin-Mediated Inhibition of Chemotherapy-Induced Apoptosis (2000) | Dr. Orlowski investigated the possible inhibitory action of the spice tumeric on cancer chemotherapeutic agents, both in tumor bearing mice and in tissue culture systems. | North Carolina | North Carolina | Robert Orlowski, MD, PhD | Breast | Curcumin | |||
| Coumarin Metabolism: Role in Mutagenesis and Chemoprotection (1992) | Dr. Goeger evaluated whether coumarin, from edible plants, might be a useful chemopreventive agent in humans by studying its anticarcinogenic properties and metabolism in chick embryo preparations, which metabolize it similarly to human liver preparations. | Texas | Texas | Douglas E Goeger, PhD | Other | coumarin, chick embryo | |||
| Corticotropin Releasing Hormone and Cancer Anorexia (2003) | Many causes have been suggested for cancer anorexia but none have so far been able to explain the effects of a tumor on brain mechanisms that control feeding. This study sought to determine whether elevated levels of the brain peptide corticotropin releasing hormone (CRH), which inhibits feeding in fibrosarcoma tumor-bearing rats, promotes anorexia. | Ohio | Ohio | William T Chance, PhD | Other | corticotropin releasing hormone | |||
| Cooked Meat, DNA Repair Genes and Breast Cancer Risk, Recurrence and Survival (2003) | Dr. Steck examined whether human subjects with both high intake of well-done meat containing carcinogens and less forms of DNA repair genes are at increased risk for breast cancer. | North Carolina | North Carolina | Susan Steck, PhD, MPH, RD | Breast | cooked meat, DNA repair genes | |||
| Control of Prostate Carcinogenesis by PC-SPES (2001) | Dr. Hsieh studied the mechanism by which PC-SPES, a seven component herbal preparation, inhibits growth arrest in the G1/S phase and down regulation of the prostate specific antigen. | New York | New York | Tze-chen Hsieh, PhD | Prostate | PC-SPES | |||
| Control of Nuclear Retinoid Receptor Expression (1994) | Dr. Niles studied the role of retinoic acid in prevention and treatment of certain types of cancer and the way these effects are mediated by nuclear retinoic acid receptors. He discovered that an important regulatory molecule, cyclic AMP, can decrease the amount of these receptors and potentially interfere with the action of retinoic acid. | West Virginia | West Virginia | Richard M Niles, PhD | Multiple Sites | retinoic acid receptors, cyclic AMP | |||
| Control of Cancer Cell Growth by Vitamin A (1987) | Dr. Niles studied the mechanism by which retinoic acid, a form of vitamin A, inhibits the promotion and growth of tumor cells by interacting with messengers in the cell. | Massachusetts | Massachusetts | Richard M Niles, PhD | Skin | retinoic acid | |||
| Control of Cancer Cachexia by Suppression of Post Pradial Glycogenesis (1993) | Dr. Emery looked at the effect of 3-mercatopicolinic acid (3-MDA) as an inhibitor of gluconeogenesis. He attempted to normalize the rate of glycogenesis in the liver in hopes of avoiding cancer cachexia and allowing for more aggressive treatments for cancer patients. | United Kingdom | United Kingdom | Peter W Emery, PhD | Other | 3-mercatopicolinic acid, gluconeogenesis | |||
| Comparative Hormonal Effects of Diets Containing Soy and Animal Protein (2001) | Dr. Lu studied whether both the amount and type of dietary protein may determine hormone levels and thus influence breast cancer risk. | Texas | Texas | Lee-Jane W Lu, PhD | Breast | protein, soy | |||
| Colon Tumor Inhibition by N-3 Lipids: Role of a Second Messenger (1991) | Dr. Broitman investigated how omega-3 fatty acids from fish oil in the diet might alter signals inside cells and thereby prevent the growth and spread of colon tumors. | Massachusetts | Massachusetts | Selwyn A Broitman, PhD | Colon/Rectum | omega-3, fish oil | |||
| Colon Carcinogenesis: Nutritional Modulation of Biomakers (1991) | Dr. Hardman sought to determine if cellulose fiber in the diet blocks the activation of the K-ras-oncogene and thereby decreases colon cancer. | Texas | Texas | W. Elaine Hardman, PhD | Colon/Rectum | cellulose fiber, K-ras oncogene | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Colon Cancer, Vitamin A and Dietary Fat (1985) | Dr. Newberne studied in rats how increasing the amount of vitamin A in the diet might lower the risk of developing colon cancer caused by eating a high-fat diet. | Massachusetts | Massachusetts | Paul M Newberne, DVM, PhD | Colon/Rectum | Vitamin A | |||
| Colon Cancer Prevention by the Black Pepper Alkaloid, Piperine, and the Green Tea Polyphenol (-)- Epigallocatechin-3-gallate (2010) | This study is testing the hypothesis that the compounds piperine, found in black pepper, and epigallocatechin-3-gallate (EGCG), found in green tea, will synergistically inhibit inflammation-related colon carcinogenesis. Experiments will explore the effects of piperine increasing the bioavailability of ECGC both in animal models and humans. | Pennsylvania | Pennsylvania | Joshua D Lambert, PhD | Colon/Rectum | green tea, black pepper, epigallocatechin-3-gallate, piperine, inflammation, bioavailability | |||
| Colon Cancer Prevention by Dietary Apigenin (1996) | Dr. Birt investigated whether realistic levels of the dietary flavonoid apigenin can inhibit experimental colon carcinogenesis in rats and what are the basic mechanisms for any protective action. | Nebraska | Nebraska | Diane F Birt, PhD | Colon/Rectum | dietary flavonoid, apigenin | |||
| Colon Cancer Inhibition by INSP6 (1992) | Dr. Shamsuddin evaluated whether dietary inositol hexaphosphate (phytic acid), a component of grains, might modulate the secretion of a pre-cancerous marker for colon cancer and thus be useful in the prevention of this cancer. This study was supported by a Matching Grant from AICR and Kellogg Company. | Maryland | Maryland | Abulkalam M Shamsuddin, MD, PhD | Colon/Rectum | phytic acid | Legumes (Dry Beans, Peas & Lentils) | ||
| CLA Modulation of Mammary Stroma in Breast Cancer Prevention (2002) | Dr. Ip investigated the effect of conjugated linoleic acid as an inhibitor of the type of mammary cell growth that would favor tumor extension. | New York | New York | Margot M Ip, PhD | Breast | conjugated linoleic acid | |||
| Circulating Promoters of Cancer Cachexia Asociated Lipolysis (2007) | The objective of this study was to test the hypothesis that one or more circulating factors present in the serum of cancer patients are responsible for cachexia. It was proposed that these factors alter adipocyte biology and fat metabolism, resulting in loss of body fat. The project was important since there are few clues as to the molecular basis of cachexia. | Louisiana | Louisiana | Lauri O Byerley, PhD, RD | Other | adipocyte, lipolysis | |||
| Chronobiological Principles to Maximize Efficacy of Alternative Dietary Therapeutics (2003) | Dr. Burton investigated how circadian rhythms affect vitamin D, curcumin and sodium selenite efficacy against androgen- sensitive and androgen- insensitive prostate cancer xenographs. | New Jersey | New Jersey | Jack Burton, MD | Prostate | circadian rythms, vitamin D, curcumin, sodium selenite | |||
| Chronic Alcohol Intake and Chemically-Induced Mammary Carcinogenesis (1988) | Dr. Singletary studied whether the long-term consumption of alcohol increases the risk of developing breast cancer and if it does this by altering the normal development of breast cells or by interfering with the metabolism and disposal of carcinogens in breast tissue. | Illinois | Illinois | Keith W Singletary, PhD | Breast | metabolism, carcinogens | |||
| Cholecystokinin Effect on Pancreatic Growth and Tumors (1989) | Dr. Adrian sought to determine if a high-fat diet increases the risk of developing pancreatic cancer because it stimulates the release of cholecystokinin, an intestinal hormone which may facilitate the development of cancer. | Nebraska | Nebraska | Thomas E Adrian, PhD | Pancreas | high-fat diet, cholecystokinin | |||
| Chemopreventive Potential of Oltipraz on BOP-Induced Ductal Pancreatic Carcinoma Development in Syrian Hamsters (1993) | Dr. Ruggeri studied the ability of oltipraz, a sulfur containing antioxidant similar to the anti-cancer agents found in cruciferous vegetables, to inhibit the development of abnormal and cancer lesions in the pancreas. | Pennsylvania | Pennsylvania | Bruce A Ruggeri, PhD | Pancreas | oltipraz, sulfur, antioxidant | Squash | ||
| Chemopreventive Modulation of the Mammary Stromal Vascular Cell by Conjugated Linoleic Acid (2006) | This research examined how conjugated dietary fatty acids infuence stromal cells to inhibit blood vessel growth in rat mammary tumors. | New York | New York | Patricia Masso-Welch, PhD | Breast | conjugated dietary fatty acids | |||
| Chemopreventive Effects of Vitamin A (1992) | Dr. Redlich investigated whether chemopreventive therapy with vitamin A might reduce both bronchial metaplasia and lung inflammation and prevent lung cancer in high risk populations. Mechanistic studies included investigating the effect of retinol and beta-carotene on cytokine biomarkers. | Connecticut | Connecticut | Carrie A Redlich, MD, MPH | Lung | Vitamin A, retinol, beta-carotene | Cherries, Squash, Grapefruit | ||
| Chemopreventive Effect of the Dietary Probiotic VSL#3 on Colitis-associated Colorectal Cancer (2010) | This study is investigating whether the consumption of specific health-promoting bacteria, taken in the form of a probiotic supplement, can prevent the development of signs of colorectal cancer that result from inflammatory bowel disease (IBD). The study also aims to determine if the beneficial bacteria have replaced the harmful bacteria in the gastrointestinal tract after long-term consumption of the probiotic supplement, and how the bacteria elicit beneficial effects. | North Carolina | North Carolina | United States | Christian 0 Jobin, Ph.D. | Colon/Rectum | Probiotic, colon cancer, inflammatory bowel disease, VSL#3 | ||
| Chemopreventive Effect of the Dietary Probiotic VSL#3 on Colitis-associated Colorectal Cancer (2010) | This study is investigating whether the consumption of specific health-promoting bacteria, taken in the form of a probiotic supplement, can prevent the development of signs of colorectal cancer that result from inflammatory bowel disease (IBD). The study also aims to determine if the beneficial bacteria have replaced the harmful bacteria in the gastrointestinal tract after long-term consumption of the probiotic supplement, and how the bacteria elicit beneficial effects. | North Carolina | North Carolina | Christian Jobin, PhD | Colon/Rectum | Probiotic, colon cancer, inflammatory bowel disease, VSL#3 | |||
| Chemopreventive Effect of the Dietary Probiotic VSL#3 on Colitis-associated Colorectal Cancer (2010) | This study is investigating whether the consumption of specific health-promoting bacteria, taken in the form of a probiotic supplement, can prevent the development of signs of colorectal cancer that result from inflammatory bowel disease (IBD). The study also aims to determine if the beneficial bacteria have replaced the harmful bacteria in the gastrointestinal tract after long-term consumption of the probiotic supplement, and how the bacteria elicit beneficial effects. | North Carolina | North Carolina | Christian Jobin, PhD | Colon/Rectum | Probiotic, colon cancer, inflammatory bowel disease, VSL#3 | |||
| Chemopreventive Effect of the Dietary Probiotic VSL#3 on Colitis-associated Colorectal Cancer (2010) | This study is investigating whether the consumption of specific health-promoting bacteria, taken in the form of a probiotic supplement, can prevent the development of signs of colorectal cancer that result from inflammatory bowel disease (IBD). The study also aims to determine if the beneficial bacteria have replaced the harmful bacteria in the gastrointestinal tract after long-term consumption of the probiotic supplement, and how the bacteria elicit beneficial effects. | North Carolina | North Carolina | Christian Jobin, PhD | Colon/Rectum | Probiotic, colon cancer, inflammatory bowel disease, VSL#3 | |||
| Chemoprevention of Pancreatic Cancer by Dietary Monoterpenes (1996) | Dr. Crowell used a hamster model of pancreatic cancer to determine whether some commonly found dietary constituents, specifically monoterpenes, can help prevent this type of cancer and to study the mechanisms of action of these monoterpenes on pancreatic cells in culture. | Indiana | Indiana | Pamela L Crowell, PhD | Pancreas | monoterpenes | |||
| Chemoprevention of her2/neu Overexpressing Breast Cancer (2005) | This study examined the role of conjugated linoleic acid (CLA) isomers, found not only in foods but also when used as a dietary supplement, as possible tumor promoting and metastasis-preventing agents. | New York | New York | Margot M Ip, PhD | Breast | conjugated linoleic acid, dietary supplements, her2/neu | |||
| Chemoprevention of HER2/NEU Overexpressing Breast Cancer (2008) | Conjugated linoleic acid (CLA), a family of fatty acids, occurring in dairy products and ruminant meat is a potent inhibitor of mammary carcinogenesis in rats. This study focused on elucidation of the mechanisms for the tumourigenesis stimulatory effects of t10,c12-CLA on erbB2/her2/neu overexpressing mammary epithelium in mice. It investigated the role of stromal-epithelium interactions, the possible role of IGF-1/insulin receptor mediated signal route, and examined the PI3K/AKT/mTOR/CXC4 signal pathway. | New York | New York | Margot M Ip, PhD | Breast | conjucated linoleic acid, her2/neu | |||
| Chemoprevention of Her2 Positive Breast Cancer by Red Wine Phytochemicals (2007) | This study investigated the inhibition of breast cancer risk by red wine phytochemicals due to suppression of HER2 oncogene and HER2 signalling in adult mice, and determined whether aromatase inhibitors in red wine given during prepuberty increase breast cancer risk. | Texas | Texas | Nameer Kirma, PhD | Breast | red wine, phytochemicals, her2, aromatase inhibitors | |||
| Chemoprevention of DSS-induced Colitis and Colorectal Cancer by Dietary Vitamin D in Mice with Defective TGF Signaling (2009) | Dr. Maggio-Price examined how vitamin D helps to regulate genes that keep colon cells healthy and cancer-free. | Washington | Washington | Lillian Maggio-Price, PhD, VMD | Colon/Rectum | DSS-induced colitis, TGF signaling | |||
| Chemoprevention of Dietary Carcinogen, 2-Amino-1-Methyl-6-Phenylimidazo [4,5-b] Pyridine(PhIP) Induced Colon Cancer by Sulforaphane (2003) | Dr. Thimmulappa investigated how the chemopreventive agent sulforaphane, from broccoli, can prevent dietary carcinogens derived from cooked red meat inducing colon cancer. | Maryland | Maryland | Rajesh K Thimmulappa, PhD | Colon/Rectum | sulforaphane, broccoli, cooked red meat | Broccoli & Cruciferous Vegetables | ||
| Chemoprevention of Colon Cancer Using Bromelain from Pineapple (2006) | This study used bromelain from pineapples to decrease the appearance of infammation, which is a precursor to intestinal cancer in a mouse model. | North Carolina | North Carolina | Laura P Hale, MD, PhD | Colon/Rectum | bromelain, pineapples, inflammation | Apples | ||
| Chemoprevention of Cancer: Control by ?-Carotene and Retinoids of Growth, Differentiation, and Viral Gene Expression in HPV16-Transformed Human Epithelial Cell (1988) | Dr. Creek investigated whether vitamin A or its precursor beta-carotene can control the development of cancer, by examining their effect on the growth and differentiation of human skin cells which have been altered by a virus involved in cervical cancer. | South Carolina | South Carolina | Kim E Creek, PhD | Cervix | beta-carotene, HPV | Grapefruit | ||
| Chemoprevention of Cancer: Control by Retinoic Acid of the Early Stages of Human Keratinocyte Transformation by Oncogenic Human Papillomaviruses (1991) | Dr. Creek investigated whether retinoic acid inhibits the transformation, growth, and differentiation of skin cells infected with human papillomavirus by inhibiting the expression of cancer-causing genes called oncogenes. | South Carolina | South Carolina | Kim E Creek, PhD | Cervix | retinoic acid, HPV | |||
| Chemoprevention of Cancer by Cabbage Extracts (1986) | Dr. Bresnick tested whether the addition of large amounts of cabbage to the diet can prevent the development of breast cancer or the spread of cancer to the lungs. | Nebraska | Nebraska | Edward Bresnick, PhD | Breast | cabbage | |||
| Chemoprevention of Angiogenesis and Brain Tumor Growth by Copper Reduction (1995) | Based on the observation that withdrawal of the micronutrient copper suppressed intracerebral tumor growth in animal models, Dr. Brem studied the molecular process by which dietary copper is needed for angiogenesis. | Illinois | Illinois | Steven Brem, MD | Nervous System | copper, brain tumor | |||
| Chemoprevention by the Isoflavone Genistein in a Rat Model of Breast Cancer (1992) | Dr. Barnes evaluated the effectiveness of genistein, an isoflavone in soybeans, in preventing breast cancer and studied if the cancer preventive properties of genistein might be enhanced by other natural ingredients in soybeans. This project was supported by a matching grant from AICR and Protein Technologies International. | Alabama | Alabama | Stephen Barnes, PhD | Breast | ||||
| Chemoprevention by the Bitter Principles of Citrus Fruits (1988) | Dr. Lam explored the possibility that certain bitter-tasting substances found in citrus fruits can stimulate the body�s natural metabolic defenses to deactivate potential carcinogens. | Minnesota | Minnesota | Luke K Lam, PhD | Breast, Lung, Stomach | citrus fruits | Apples, Cherries | ||
| Chemoprevention and the BMI-1 Polycomb Gene (2007) | The polycomb group of genes encode proteins that enhance cell survival. Bmi-1 is a protein that is over expressed in skin cancer cells. This study examined how EGCG reduces Bmi-1 levels and activity. | Maryland | Maryland | Richard L Eckert, PhD | Skin | EGCG, Bmi-1 | |||
| Characterization of Retinoic Acid Receptors and Their Role in the Chemoprevention of Cancer (1992) | Dr. Niles sought to determine the mechanism by which vitamin A works to regulate and retard the growth of cancer cells. His previous research indicated that regulation is linked to three different retinoid receptors, which characterized in this study. | West Virginia | West Virginia | Richard M Niles, PhD | Other | retinoic acid receptors | |||
| Cereal Derived (1-3), (1-4)-beta-Glucan Enhances Anti-tumor Immunity (2003) | Dr. Cheung�s studied if dietary beta-glucan enhances the anti-tumor effect of specific IgM antibodies against small cell lung cancer as well as the effects of anti-tumor vaccines that induce IgM antibodies on lymphoma and melanoma. | New York | New York | Nai-Kong Cheung, MD, PhD | Lung, Blood/Bone Marrow/Lymph, Skin | beta-glucan, IgM antibodies, small cell lung cancer | |||
| Cellulose Structure and Inhibition of Colon Carcinogenesis (1989) | Dr. Penner examined how differences in the physical structure of dietary fiber can affect its capacity to prevent colon cancer. | Oregon | Oregon | Michael H Penner, PhD | Colon/Rectum | cellulose structure | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Cellular Retinol Binding Protein and Breast Cancer (1997) | Dr. Talmage studied the involvement of cellular proteins which bind to the vitamin A derivatives, in this case retinol, in the suppression of and death of breast cancer cells, using human breast cancer cells as the model. | New York | New York | David A Talmage, PhD | Breast | retinol | |||
| Cellular Proliferation in the Breast (1992) | Dr. Boyd sought to determine if a change to a low-fat, high-carbohydrate diet can reduce human mammary epithelial cell proliferation in benign breast disease and lower breast cancer risk. A quantitative image analysis system was used to evaluate needle biopsies of breast epithelial cells. | Canada | Canada | Norman F Boyd, MD, DSc, FRCPC | Breast | low-fat, high-carbohydrate diet, benign breast disease | |||
| Cell Proliferation and Esophageal Carcinogenesis in Zinc-deficient Rats (2004) | This study investigated the effect of zinc defcient diets on the processes of cell growth and death, using the rat esophagus as a model system. | Pennsylvania | Pennsylvania | Louise Y Fong, PhD | Esophagus | zinc deficiency | |||
| Cell Proliferation and Esophageal Carcinogenesis in Zinc Deficient Rats (1997) | Dr. Fong characterized the cell cycle factors involved in the increased cell proliferation of the esophageal cells of rats treated with a carcinogen while on a zinc deficient diet. | Pennsylvania | Pennsylvania | Louise Y Fong, PhD | Esophagus | zinc deficiency | |||
| Cell Proliferation and Esophageal Carcinogenesis in Zinc Deficient Rats (1999) | Dr. Fong investigated the role of cell growth and death and various regulatory genes and proteins in esophageal carcinogenesis, using rats fed a zinc deficient diet as a model. | Pennsylvania | Pennsylvania | Louise Y Fong, PhD | Esophagus | zinc deficiency | |||
| Cell Proliferation and Esophageal Carcinogenesis in Zinc Deficient Rats (2002) | Dr. Fong studied the effect of zinc deficient diets on the processes of cell growth and death, using the rat esophagus as a model system. | Pennsylvania | Pennsylvania | Louise Y Fong, PhD | Esophagus | zinc deficiency | |||
| Cell Proliferation and Esophageal Carcinogenesis in Zinc Deficient Rats (1995) | During the previous funding period, Dr. Fong obtained data to demonstrate that esophageal tumor incidence was 100% in the zinc deficient versus 23% and 7% in the zinc sufficient and ad libitum pair fed rats. She found that prolonged cell proliferation induced by zinc deficiency can lead to esophageal tumorigenesis. Dr. Fong continued her biochemical analysis of tissues collected to further clarify the relationship of zinc to carcinogenesis. | Pennsylvania | Pennsylvania | Louise Y Fong, PhD | Esophagus | zinc deficiency | |||
| Causal Relationship Between Fusel Alcohols and Esophageal Cancer (1992) | Dr. Newberne evaluated whether fusel alcohols, contaminants found in inexpensive wines and apple-based spirits, might enhance or promote cancer of the esophagus that is induced by methylbenzylnitrosamine in rats. | Massachusetts | Massachusetts | Paul M Newberne, DVM, PhD | Esophagus | fusel alcohol, methylbenzylnitrosamine | Apples | ||
| Carotenoid Effects on Transcription and Growth in Tumors (1994) | Dr. Benbrook investigated the mechanism by which dietary carotenoids, after being converted into retinoic acid in the body, inhibit the growth and development of tumors. Specifically, her studies aimed to discover how carotenoids and vitamin A change the balance of proteins that make up a cell. Using a cervical cancer cell system, she sought to determine how these nutrients inhibit cervical tumor growth. | Oklahoma | Oklahoma | Doris M Benbrook, PhD | Cervix | retinoic acid | Squash | ||
| Cancer Preventive Effects of Beta-Carotene: Possible Mechanism of Action (1983) | Dr. Alam tested whether the addition of beta-carotene to the diet can prevent the growth of salivary gland tumors and whether this beta-carotene affects the composition or the functioning of the membranes in the normal gland and in tumors. | Louisiana | Louisiana | Syed Q Alam, PhD | Head and Neck | beta-carotene | Grapefruit | ||
| Cancer Prevention with Dietary Potassium Hydrogen Glucarate (1992) | Dr. Walaszek is comparing the ability of potassium and calcium salts of D-glucarate in preventing the chemical induction of mammary gland cancer in rats and will determine the effect of the glucarate on beta-glucuronidase and proliferative activity in the mammary tumors. | Texas | Texas | Zbigniew Walaszek, PhD | Breast | potassium, calcium, D-glucarate | |||
| Cancer Chemoprotective Activities by Dietary Phytochemicals (2007) | 0 | Maryland | Maryland | Paul Talalay, PhD | Other | ||||
| Cancer Chemoprotective Activities by Dietary Phytochemicals (2007) | 0 | Maryland | Maryland | Paul Talalay, PhD | Other | ||||
| Cancer Chemoprevention by Green Tea Polyphenols (1990) | Dr. Mukhtar sought to determine whether extracts from green tea might prevent chemicals from causing tumors of the skin, lung, and forestomach of mice. While he fed the mice the tea extracts for potential protection, he exposed the mice to polycyclic aromatic hydrocarbons (PAHs). These are chemicals in the environment that are known to cause cancer. | Ohio | Ohio | Hasan Mukhtar, PhD | Lung, Skin, Stomach | green tea, polycyclic aromatic hydrocarbons | Legumes (Dry Beans, Peas & Lentils) | ||
| Cancer Chemoprevention by Green Tea Components (1992) | Dr. Mukhtar studied the inhibitory effects of green tea extracts (fed in the drinking water) on chemically-induced skin, lung, and forestomach cancers in mice. | Ohio | Ohio | Hasan Mukhtar, PhD | Skin | green tea extracts | |||
| Cancer Chemoprevention by Curcumin: Mechanistic Studies (1995) | Dr. Limtrakul sought to determine whether dietary curcumin, a food seasoning, would inhibit skin carcinogenesis in animal models. To investigate the mechanism of action by which curcumin affects genetic changes in carcinogen-induced responsive genes, she studied the expression of v-ras and v-fos oncogenes and protein kinase C gene families in the mouse epidermis after treatment with different diets. | Thailand | Thailand | Porn-ngam Limtrakul, PhD | Skin | curcumin, v-ras, v-fos, oncogenes, protein kinase C | |||
| Cancer Anorexia: Peripheral Manifestation of Abnormal Hypothalamic Neurotransmitter Status Secondary to Cancer (2001) | Dr. Meguid used a rat model of cancer anorexia to determine the role of neurotransmitters, their interactoins, and how branched chain amino acid supplementation is effective in anorexia. | New York | New York | Michael M Meguid, MD, PhD, FACS | Other | cachexia, neurotransmitters, branched chain amino acid | |||
| Can Putative Preneoplastic Foci be Used to Evaluate Inhibitors of Colon Carcinogenesis (1989) | Dr. Pretlow sought to determine whether early changes in colon tissue, such as enzyme-altered foci and aberrant crypts, can be used to predict increased risk for colon cancer and whether selenium or phytate in fiber-rich foods can prevent the transition to colon cancer. | Ohio | Ohio | Theresa P Pretlow, PhD | Colon/Rectum | enzyme-altered foci, abberant crypts, selenium, phytate | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Calorie Restriction, Lipid Peroxidation, and Mammary Tumor Prevention (2009) | Obesity is a risk factor for postmenopausal breast cancer. This study examined the role reduced caloric intake may play in reducing breast cancer risk. Studies have shown that periods of intermittent caloric restriction may provide protection from tumor development. The objective of this research was to determine the relationship between lipid peroxidation and intermittent caloric restriction as compared to ad libitum feeding or chronic caloric restriction. | Minnesota | Minnesota | Christine Seppanen, PhD | Breast | caolric restriction, lipid peroxidation | |||
| Caloric Restriction, Aberrant Crypt Foci and Development of Colon Cancer (1995) | Dr. Bird investigated whether high or low fat diets and caloric restriction alter the response, in an animal model, to determine whether aberrant crypt foci (ACF) can predict carcinogenicity. Using the ACF system, Dr. Bird sought to determine if colon cancer development can be prevented in high risk individuals by dietary means. | Canada | Canada | Ranjana P Bird, PhD | Colon/Rectum | high-fat diet, low-fat diet, aberrant crypt foci, caloric restriction | |||
| Caloric Restriction and Gene Expression in Agouti Mice (1994) | Dr. Visek investigated how dietary fat and calories alter the expression of genes to enhance the development of breast cancer. By identifying individual diet-regulated genes, particularly those which respond to caloric restriction, Dr. Visek studied their expression during tumor formation under various dietary conditions. | Illinois | Illinois | Willard J Visek, MD, PhD | Breast | calories, diet-regulated genes | |||
| Calcium and Vitamin D Interactions in Prostate Carcinogenesis (2005) | This study examined the role of interactions between vitamin D and calcium in prostate carcinogenesis. A novel and intriguing hypothesis was tested to explain the relationship of elevated prostate cancer risk associated with higher calcium intakes, specifcally that the dietary calcium blocks the hydroxylation of 25-OH D to 1,25(OH)2D in the kidney, in a mouse transgenic model. | Ohio | Ohio | Steven K Clinton, MD, PhD | Prostate | calcium | |||
| Butyrate-mediated Signal Transduction in Colonocytes: Role of cAMP-dependent Protein Kinase (1995) | Dr. Aukema investigatedthe diverse actions of butyrate, a major by-product of dietary fiber breakdown by bacteria in the colon, on cell proliferation. Using a unique colonic cell culture system, Dr. Aukema sought to determine the effect of butyrate under conditions seen with tumor cell cultures and under normal conditions to elucidate the potential anti-cancer properties of dietary fiber. | Texas | Texas | Harold M Aukema, PhD | Colon/Rectum | butyrate | Legumes (Dry Beans, Peas & Lentils), Squash, Cherries | ||
| Breast Cancer Prevention by CLA Modulation of Mammary Stromal Differentiation (1999) | Dr. Ip studied different isomers of conjugated linoleic acid for their effects on various cell growth processes, with emphasis on angiogenesis and capillary invasion of tumors. | New York | New York | Margot M Ip, PhD | Breast | conjugated linoleic acid | |||
| Breast Cancer Cell Cycle Protein Regulation by a Metabolite of Vitamin A (1996) | The role of estrogen and of the estrogen receptor on regulation of the Bcl-2 gene, implicated as necessary for survival of the MCF-7 line of breast cancer cells, was investigated by Dr. Pratt. Further, the function of progestins and various growth factors in regulating Bcl-2 and other members of this gene family were examined. | Canada | Canada | M.A. Christine Pratt, PhD | Breast | estrogen, Bcl-2 gene, progestins, growth factor | |||
| Breast Cancer and eNOS Suppression by Quercetin (2005) | The intent of this postdoctoral application was to determine how quercetin inhibits endothelial nitric oxide synthase (eNOS) activity, to characterize the effect of quercetin on endothelial cell proliferation and to establish the capacity of quercetin to inhibit tumor angiogenesis. | Georgia | Georgia | Steven J Jackson, MS, PhD | Breast | quercetin, endothelial nitric oxide synthase (eNOS) | Blueberries, Apples | ||
| Branched Chain Amino Acid-Enriched Total Parental Nutrition in Cancer Cachexia (1983) | Dr. Bistrian sought to determine if feeding a special mixture of amino acids can stimulate cachectic cancer patients to synthesize proteins normally after consuming a conventional mixture of amino acids. | Massachusetts | Massachusetts | Bruce R Bistrian, MD, PhD | Other | amino acids | |||
| Biologic Effects of Flaxseed in Patients with Breast Cancer (1996) | In this intervention study, Dr. Thompson investigated the effect of dietary flaxseed (baked in a muffin) in postmenopausal women with breast cancer, and evaluated levels of plasma sex hormones, urinary lignan excretion and tumor growth as markers of any influence flaxseed may have to inhibit breast cancer. | Canada | Canada | Lilian U Thompson, PhD | Breast | flaxseed | Flaxseed, Legumes (Dry Beans, Peas & Lentils) | ||
| Biologic Effect of Beta-cryotixanthin on Smoke-induced Lung Lessions in Ferrets (2007) | The purpose of this application was to determine the chemopreventive effects of beta-cryptoxanthin on tobacco smoke-induced lung lesions in a ferret animal model and to determine the effects of various molecular markers as well as DNA damage in the lungs of ferrets. | Massachusetts | Massachusetts | Chun Liu, MD | Lung | beta-cryptoxanthin, tobacco smoke, lung lesions, DNA damage | |||
| Bioflavonoids and Prostatic Cancer Metastasis in Transgenic Mice (1998) | Dr. Markaverich sought to determine the effect of two dietary bioflavonoids on the establishment, progression and metastatic potential of prostate cancer in a mouse model which mimics prostate cancer in humans. | Texas | Texas | Barry Markaverich, PhD | Prostate | bioflavonoids | |||
| Bioflavonoid Inhibition of Carcinogenesis (1986) | Dr. Markaverich studied how certain substances found in fruits and vegetables can inhibit the development of cancer by interfering with DNA synthesis and the reproduction of cells. | Texas | Texas | Barry M Markaverich, PhD | Breast | bioflavonoids | Squash, Cherries | ||
| Biochemical Toxicology of Novel Heterocyclic Aromatic Amines in Cooked Meats (2005) | This study investigated the formation of possible novel heterocyclic amines in cooked meats and whether preliminary tests show a cancer risk. | New York | New York | Robert Turesky, PhD | Other | heterocyclic amines, meat intake | |||
| Biochemical and Molecular Basis for the Cancer Chemopreventive Activity of Dietary Selenium Supplementation (1998) | Dr. Nelson studied the chemopreventive effects of selenomethionine on the molecular processes involved in colon carcinogenesis in rats, especially with regards to intracellular polyamine levels and their effects on cell characteristics such as proliferation and apoptosis. | Arizona | Arizona | Mark A Nelson, PhD | Colon/Rectum | Selenium | |||
| Biochemical and Molecular Basis for the Cancer Chemopreventive Activity of Dietary Selenium Supplementation (2001) | Dr. Nelson examined cellular components for their possible role in cancer chemopreventive action of dietary selenium compounds. | Arizona | Arizona | Mark A Nelson, PhD | Colon/Rectum | Selenium | |||
| Bioavailability of Dietary Glutathione as an Anticarcinogen (1987) | Dr. Jones sought to determine which foods contain glutathione, a natural compound important in the metabolic inactivation of carcinogens, and how glutathione is digested and absorbed from the diet. | Georgia | Georgia | Dean P Jones, PhD | Other | glutathione | |||
| Beta-Carotene Modulation of Lymphokine Activated Killer Cell Activity (1991) | Dr. Akporiaye investigated how beta-carotene might turn on our natural immune response, by stimulating LAK or lymphokine activated killer cells, to inhibit the growth of tumors. | Arizona | Arizona | Emmanuel T Akporiaye, PhD | Blood/Bone Marrow/Lymph | beta-carotene | Grapefruit | ||
| Benefit of Walnut Consumption Against Cancer (2005) | Dr. Hardman�s studies were designed to determine if consumption of clinically relevant amounts of walnuts in diet could slow the growth of invasive human breast cancer cells implanted in laboratory mice. | West Virginia | West Virginia | W. Elaine Hardman, PhD | Breast | Walnuts | |||
| Benefit of Walnut Consumption Against Breast and Prostate Cancer (2007) | In this study, Dr. Hardman sought to determine the efficacy of dietary supplementation of walnuts in delaying the development and progression of breast and prostate cancer. Dr. Hardman used a special transgenic mouse model to better understand the alterations of molecular pathways related to carcinogenesis, metastasis and treatment. | West Virginia | West Virginia | W. Elaine Hardman, PhD | Breast | Walnuts | |||
| Azoxymethane-induced Colon Cancer in Rats Fed Varying Levels of Bean(Phaseolous vulgaris) Dietary Fiber (1991) | Dr. Hughes sought to determine whether fiber from pinto beans in the diet may prevent the development of colon cancer. | Arizona | Arizona | Joseph S Hughes, PhD | Colon/Rectum | fiber, pinto beans | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Attenuation of Cancer Cachexia by Reduction of TNF and IL-1 Productions (1993) | TNF? and IL-1? play an active role in the cancer process by suppressing appetite, inducing sleepiness, fever, pain, and breaking down fat and muscle tissue in cancer patients. Curcumin, a component of curry and an antioxidant, reduces the production of TNF? and IL-1? in a leukemia cell line. Dr. Chan studied a variety of spices and herbs to see if they would inhibit TNF? and IL-1? and studied the mechanisms by which this occurs in a mouse model. | New Jersey | New Jersey | Marion M Chan, PhD | Blood/Bone Marrow/Lymph | TNF? and IL-1?, curcumin, leukemia | |||
| Assessment of Risk of Preneoplastic Lesions in Respiratory Epithelia of Smokers (1990) | Dr. Hine sought to determine whether deficiencies in folic acid and vitamin B12 might increase the susceptibility to cancer causing agents. She also explored whether low levels of the vitamins are associated with increased damage to DNA, the genetic material, a condition that precedes tumor development. The studies were done in smokers to see if the vitamin deficiencies predispose them to mouth and lung cancer. | Alabama | Alabama | R. Jean Hine, PhD | Lung, Oral | Vitamin B12, lung, head and neck | |||
| Assessing the Specificity of Walnut Feeding Effects on TRAMP Tumor Growth (2010) | This animal study is investigating the possible role of whole walnuts and/or its fats in the development of prostate cancer. Experiments will determine how different walnut-focused diets effect tumor growth, genes, and cell-signaling proteins, as well as examine the concept of food synergy. | California | California | Paul Davis, PhD | Prostate | walnuts | |||
| Assays on Blood & Urine Specimens Obtained in a Human Subject Survey on Diet & Cancer Relationships in The Peoples Republic of China (1983) | A survey of possible causes of cancer and other diseases was undertaken in 64 mostly rural counties of the People�s Republic of China, with particular focus on dietary habits. Approximately 330 items of information were documented for 6500 adults, derived from 1) a 3-day dietary survey, 2) analyses of blood, urine, and food samples, and 3) collation of responses to questionnaires about personal lifestyles. The objective of the study was to examine the contribution of various environmental factors to disease risk in the context of the complexities of the human environment. | New York | New York | T. Colin Campbell, PhD | Breast, Colon/Rectum, Esophagus, Liver, Lung, Nasopharynx, Stomach | China, dietary habits, environmental risk factors | Legumes (Dry Beans, Peas & Lentils) | ||
| Ascorbyl Esters as Antiglioma Agents: Mechanistic Study (1994) | Dr. Kulkarni found that ascorbyl stearate, vitamin C, is a potent inhibitor of glutathione S-transferase and lipoxygenase, important enzymes for growth and proliferation of glioma (tumor) cells in culture. Screening ascorbyl derivatives as inhibitors of these enzymes in glioma cells in vitro, he sought to identify the most effective compounds for in vivo studies. Dr. Kulkarni�s long-term goal was to identify effective non-toxic therapeutic agents that can minimize drug resistance in tumor cells or act as antiglioma agents. | Florida | Florida | Arun P Kulkarni, PhD | Nervous System | glutathione S-transferase, lipoxygenase, glioma | Cranberries | ||
| Antitumor Effects of Dietary Isothiocyanates on Prostate Cancer (2001) | Dr. Tan investigated whether some isothiocyanates from vegetables can prevent prostate cancer in a mouse model. | Texas | Texas | Tse-Hua Tan, PhD | Prostate | isothiocyanates, vegetables | Broccoli & Cruciferous Vegetables, Squash | ||
| Antiproliferative Effects of Organosulfur Compounds in Garlic on Human Lung Tumor Cells (1995) | Dr. Milner aimed to elucidate the mechanism of action of an oil-soluble garlic constituent on human lung cancer cells. His studies sought to expand the understanding of the importance of minor dietary sulfur compounds found in garlic as modifiers of tumor growth. | Pennsylvania | Pennsylvania | John A Milner, PhD | Lung | garlic | |||
| Antioxidative Status of Children on Treatment for ALL (1998) | In this project, Dr. Kelly examined whether children with acute lymphoblastic leukemia have low serum antioxidant levels, as well as increased markers of oxidative stress, even if the dietary intake is sufficient; in addition the influence of chemotherapy on the markers of stress were studied. | New York | New York | Kara Kelly, MD | Blood/Bone Marrow/Lymph | acute lymphoblastic leukemia, children, oxidative stress | |||
| Antimetastatic and Anticarciongenic Effect of High-Selenium Soybeans (1998) | Dr. Yan tested the hypothesis that high-selenium soybeans have a greater inhibitory effect than low-selenium soybeans on cancer metastasis in mice and on the development of primary tumors in a rat mammary tumor model. | Nebraska | Nebraska | Lin Yan, PhD | Breast | selenium, soy beans | |||
| Antimetabolite Therapy of Tumor-Bearing Rats Receiving Total Parenteral (1986) | Dr. Chance studied combination cancer therapy using a drug called acivicin and insulin. He found that this therapy appears to prevent tumor growth and reduce the amount of weight loss in rats receiving parenteral nutrition. | Ohio | Ohio | William T Chance, PhD | Other | acivicin, insulin, tumor growth | |||
| Anticarcinogenicity of Dietary Flavonol Quercetin (1986) | Dr. Verma sought to determine if a substance called quercetin, commonly found in vegetables and fruits, can interfere with the development of skin cancer. | Wisconsin | Wisconsin | Ajit K Verma, PhD | Skin | quercetin | Blueberries, Apples, Squash, Cherries | ||
| Anticarcinogenesis Activity of Selenium (1984) | Dr. Marshall studied if the risk of developing cancer is increased by a diet deficient in selenium or decreased by supplementing the diet with selenium. | Texas | Texas | Milton V Marshall, PhD | Other | selenium | |||
| Anticancer Effects of Oils from an Echinoderm (2000) | Dr. Adrian investigated whether oils extracted from the sea cucumber, an echinoderm, can suppress the growth of human pancreatic cancer cells implanted into athymic mice. | Nebraska | Nebraska | Thomas E Adrian, PhD | Pancreas | sea cucumber | |||
| Anticancer Effects of Mixed Disulfide Conjugates of Allium Thiosulfinates and Cysteine/glutathione (2010) | This laboratory study is testing if the allium sulfur compounds cysteine and glutathione are the dietary factors derived from allium vegetables that play a role in cancer risk reduction. Cell experiments will determine the effect the compounds have on elevating cellular defenses to oxidative stress and inflammation. | Wisconsin | Wisconsin | Kirk Parkin, PhD | Breast, Colon/Rectum, Liver, Prostate | Alliums, vegetables, sulfur, inflammation, oxidative stress, antioxidants, thiosulfinates, glutathione, cysteine | Squash | ||
| Anticancer Actions of Beta-Carotene Oxidation Products (2001) | Dr. Canfield separated and identified the numerous compounds formed during oxidation of beta-carotine and studied their inhibitory action on several cancer cell lines. | Arizona | Arizona | Louise M Canfield, PhD | Lung | beta-carotene | Grapefruit | ||
| Anti-Photocarcinogenic Effect of Dietary Lycopene (2004) | This study frst tested whether the carotenoid lycopene can prevent the development of UVB induced skin cancer in a mouse model. It then evaluated the subsequent therapeutic effcacy of lycopene on established skin tumors in this system. | New York | New York | Huachen Wei, MD, PhD | Skin | lycopene, UVB | Grapefruit | ||
| Anti-Angiogenesis Effects of IP6 (2002) | Dr. Vucenik examined the action of inositol hexaphosphate or phytic acid from cereal products as an inhibitor of the growth of new blood vessels in tumor cells, presumably through reduction of growth enhancing factors such as vascular endothelial growth factor and fibroblast growth factor. | Maryland | Maryland | Ivana Vucenik, PhD | Other | phytic acid, growth factor | Legumes (Dry Beans, Peas & Lentils) | ||
| Anthropometrics and Exercise Throughout Life and Prostate Cancer (2005) | This study investigated the effects of height, weight and physical activity at various ages, and age of sexual maturation, on the risk for prostate cancer, based on the assumption that obesity, inactivity and earlier sexual maturation increase prostate cancer risk. | Washington | Washington | J. Emily J White, PhD | Prostate | height, weight, physical activity, age, sexual maturation, obestiy | |||
| Androgen Receptor Expression Regulation by Omega-3 fatty Acids in Prostate Cancer (2006) | This study examined whether omega-3 fatty acids prevent or slow progression of prostate cancer by modulation expression of androgen receptor, a protein critical for prostate cancer cell growth. | Texas | Texas | Linda A deGraffenried, PhD | Prostate | omega-3, androgen receptor, protein | |||
| an walnuts slow tumor growth and delay cancer-associated cachexia (2012) | Dr. Byerley is testing whether diets rich in walnuts will slow tumor growth and thus slow cancer-associated cachexia (wasting). | Louisiana | Louisiana | Lauri O Byerley, PhD, RD | Other | ||||
| AMPK: a Mediator of Caloric Restriction's Ability to Suppress Cancer (2006) | This study identifed the signalling pathways affected by caloric restriction that infuence tumor suppression and longevity. The hypothesis was that caloric restriction activates AMP-activated protein kinase, which phosphorylates and increases the activity of the FOXO family of Forkhead transcription factors, resulting in the inhibition of cell growth and/or apoptosis. | California | California | Anne Brunet, PhD | Other | AMPK, caloric restriction | |||
| Amino Acid Regulated Gene Expression in Tumorgenesis (2002) | Dr. Thompson examined the role of dietary amino acids, especially arginine, in regulating genes involved in human liver cancer development and progression and sought to identify other genes in this category. | Rhode Island | Rhode Island | Nancy L Thompson, PhD | Liver | arginine | |||
| Amino Acid Modification of Total Parenteral Nutrition in Cancer Therapy (1987) | Dr. Grossie explored the possibility that total parenteral nutrition feeding can be used to simultaneously nourish a cachectic cancer patient and starve his tumor by excluding certain substances from the liquid needed for the synthesis of polyamines, which are essential for the growth of a tumor. | Texas | Texas | Bruce Grossie, PhD | Other | cachexia, parenteral nutrition, polyamines | |||
| Amelioration of Adriamycin Cardiotoxicity by Dietary Antioxidants (1984) | Dr. Misra sought to determine whether dietary antioxidants, including vitamin E, can protect the heart muscle from tissue damage caused by the potent anti-cancer drug adriamycin. | Virginia | Virginia | Hara P Misra, PhD | Other | vitamin E, adriamycin | |||
| Altered Imprinting Against Mammary Cancer (1992) | Dr. Lamartiniere investigated if genistein, an extract from soybeans, provided early after birth, might afford long-term protection against breast cancer. | Alabama | Alabama | Coral A Lamartiniere, PhD | Breast | Genistein, soy | |||
| Alcohol and Breast Cancer in a Rat Model (1986) | Dr. Rogers studied female rats exposed to a potent carcinogen and whether or not the consumption of a moderate amount of alcohol increases the development of breast cancer. | Massachusetts | Massachusetts | Adrianne E Rogers, MD | Breast | carcinogens | |||
| alcium, Vitamin D and Colon Carcinogenesi (1987) | Dr. Glauert sought to determine whether increased levels of calcium and vitamin D in the diet, either alone or in combination, can prevent the development of colon cancer. | Kentucky | Kentucky | Howard P Glauert, PhD | Colon/Rectum | calcium, vitamin D | |||
| Age of Diet Modification as Related to Mammary Cancer (1984) | Dr. Silverman studied whether changing to a low-fat diet before or during puberty can cause a greater reduction in the development of breast cancer rather than switching to a low-fat diet later in life. | Ohio | Ohio | Jerald Silverman, DVM | Breast | low-fat diet, puberty | |||
| Aerobic Work and Breast Cancer Prevention (1986) | Dr. Thompson studied how the intensity, duration, and the timing of exercise, together with the level of fat in the diet, affect the development of breast cancer. | Colorado | Colorado | Henry J Thompson, PhD | Breast | fat, diet | |||
| Adolescent Diet and Lifestyle Factors and Colorectal Adenoma (2009) | Dr. Wu is analyzed the link between adolescent diets and colorectal cancer risk later in life among a large group of adult women. | Massachusetts | Massachusetts | Kana Wu, MD, MPH, PhD | Colon/Rectum | adolescent diet, physical inactivity, body fatness, alcohol, meat intake, height | |||
| Adolescent Diet and Benign Breast Disease (2009) | Dr. Frazier studied the link between adolescent lifestyle and breast cancer risk later in life by tracking the diets and activity levels of more than 9,000 girls aged 9-17. | Massachusetts | Massachusetts | Lindsay Frazier, MD, ScM | Breast | fiber, vitamin D, red meat, milk, adolescents | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Adiponectin in Colon Cancer-An Interventional Study (2008) | Dr. Mantzoros studied the effect of adiponectin or walnut diet on an animal model of colon cancer to determine the effects on growth, development and metastasis. This project was supported by a matching grant from AICR and The California Walnut Commission. | Massachusetts | Massachusetts | Christos Mantzoros, MD, DSc | Colon/Rectum | ||||
| Adherence to the Behavioral Tenets of the 1997 WCRF/AICR Cancer Prevention Recommedations in Four Nations as Assessed by Prospective Evaluation (2006) | This postdoctoral proposal evaluated dietary compliance with WCRF/AICR guidelines in populations from Guatemala, Mexico, The Netherlands and Scotland. | Guatemala | Guatemala | Marieke Vossenaar, PhD | Other | WCRF/AICR guidelines, Guatemala, Mexico, The Netherlands, Scotland | |||
| Activation of a Tumor Suppressor Gene by Nutrient Derivatives (1996) | Dr. Steinman investigated whether the protective action of butyrate, found in dietary fiber, against colon cancer involves activation of a tumor suppressor gene named p21(WAF1) by following the presence of this gene in colon biopsy samples from patients on high or low fiber diets. | Pennsylvania | Pennsylvania | Richard Steinman, MD, PhD | Colon/Rectum | butyrate, p21(WAF1) tumor supprossor gene, high-fiber diet, low-fiber diet | Apples, Blueberries, Broccoli & Cruciferous Vegetables, Cherries, Cranberries, Flaxseed, Legumes (Dry Beans, Peas & Lentils), Soy, Squash, Grapefruit | ||
| Acetlytransferase and Diet as Determinants of Cancer (1998) | Dr. Lawson explored the dietary habits and levels of certain detoxifying enzymes in pancreatic cancer patients and comparing these parameters with those in control to determine the relative influence of each factor in the disease. | Nebraska | Nebraska | Terence A Lawson, PhD | Pancreas | enzymes, dietary habits | |||
| Abnormal Receptor of a Vitamin A Derivative in Promyelocytic Leukemia (1998) | Dr. Redner continued to pursue the hypothesis that a nucleolar nucleophosmin-retinoid acid receptor gene blocks differentiation in acute promyelocytic leukemia through competition for retinoic acid receptors. | Pennsylvania | Pennsylvania | Robert L Redner, MD | Blood/Bone Marrow/Lymph | retinoic acid receptors, acute promyelocytic leukemia | |||
| Abnormal Receptor for a Vitamin A Derivative in Promyelocytic Leukemia (1996) | Based on preliminary results that showed that the specific fusion protein (NPM-RAR) inhibits differentiation of myeloid cells, Dr. Redner continued his investigations into the mechanism whereby NPM-RAR might alter vitamin A signaling and may compete with retinoic acid receptors for binding to a family of proteins which are essential to retinoic acid receptor function. | Pennsylvania | Pennsylvania | Robert L Redner, MD | Blood/Bone Marrow/Lymph | NPM-RAR, vitamin A, retinoic acid, actue promyelocytic leukemia | |||
| Abnormal Receptor for a Vitamin A Derivative in Promyelocytic Leukemia (2001) | Dr. Redner investigated, through study of fusion protein formed from the retinoic acid receptor gene and the amino terminus of the nucleophosmin gene, how retinoic acid reverses the differentiation defect in acute promyelocytic leukemia. | Pennsylvania | Pennsylvania | Robert L Redner, MD | Blood/Bone Marrow/Lymph | retinoic acid receptors, acute promyelocytic leukemia | |||
| Abnormal Receptor for a Vitamin A Derivative in Promyelocytic Leukemia (1994) | Based on the observation that Acute Promyelocytic Leukemia (APL) can be reversed by treatment with retinoic acid, a natural derivative of vitamin A, Dr. Redner investigated the molecular mechanism underlying the success of this therapy in APL. He sought to determine whether a specific abnormal fusion protein (NPM-RAR) interferes with the function of the normal retinoic acid receptor protein. | Pennsylvania | Pennsylvania | Robert Redner, MD | Blood/Bone Marrow/Lymph | acute promyelocytic leukemia, retinoic acid, vitamin A, abnormal fusion protein | |||
| Abnormal Gene Regulation By Calcium and Vitamin D In Squamous Cell Carcinoma (1992) | Dr. Bikle evaluated how calcium and vitamin D (1,25-dihydroxyvitamin D) regulate the expression of genes important for differentiation of squamous cell carcinoma cell lines. He attempted to ascertain if abnormal gene regulation might be due to missing mediators of calcium and vitamin D. | California | California | Daniel D Bikle, MD, PhD | Skin | Vitamin D, calcium, squamous cell carcinoma | |||
| Ability of n-3 Fatty Acids to Influence Colon Tumor Formation by Modulating Estrogen Action (2007) | This study examined the relationship between a fish oil diet and estradiol using an estrogen receptor (ER)-beta knockout animal model and investigated the mechanisms of cross-talk between PPAR-gamma and ER-beta using human colon cancer cells in culture. Results of the study were expected to increase understanding of the mechanisms of omega-3 fatty acids in reducing risk of premenopausal women to colon cancer. | Texas | Texas | Clinton D Allred, PhD | Colon/Rectum | estrogen receptor, PPAR-gamma, ER-beta, omega-3 | |||
| A Validation Study for a Chinese Food Frequency Questionaire (1998) | Dr. Huang developed and validated a food frequency questionnaire for China, to have better knowledge of nutrient data and associations between dietary factors, lifestyle and chronic disease, especially cancer. | New York | New York | Zhiping Huang, PhD | Other | China, dietary factors, lifestyle, chronic disease | |||
| A Study of Alpha and Gamma Tocopherol and Modulation of PPARs: Chemopreventitives in Colon Cancer (2005) | This study was designed to determine if gamma-tocopherol, one of the tocotrienols of vitamin E, induces growth arrest and apoptosis in colon cancer cell lines through a peroxisome proliferator activated receptor (PPAR)-gamma mechanism. This research was based on epidemiological studies suggesting that vitamin E negatively correlates with the incidence of colon cancer, and that the anti-proliferative effects of vitamin E are associated with PPAR-gamma. | Tennessee | Tennessee | Sharon E Campbell, PhD | Colon/Rectum | gamma-tocopherol, apoptosis, PPAR-gamma | |||
| A Randomized Double-Blinded Efficacy Trial of Alpha-Tocopherol (Vitamin E) in Patients with Persistent or Severe Breast Pain (1983) | Dr. Byrne studied the role of vitamin E in persistent breast pain in women who suffer from various forms of fibrocystic breast disease, a condition which, in some cases, causes an increased risk for breast cancer. | District of Columbia | District of Columbia | Patrick J Byrne, MD | Breast | fibrocystic breast disease | |||
| A Prospective Study of Diet and Breast Cancer in Mexico: A Feasibility Study (2005) | The diets of a group of Mexican women were studied to examine associations with breast cancer incidence. | Mexico | Mexico | Isabelle Romieu, MD, MPH, ScD | Breast | diet, Mexico | Cranberries | ||
| A Potential Role for Ascorbic Acid as a Chemosensitizing Agent in Multiple Myeloma (2000) | Dr. Grad investigated the ability of vitamin C to deplete glutathionine and act as a chemosensitizing agent in multiple myeloma, using both in vitro and in vivo tests to explore the sensitivity of multiple myeloma to antineoplastic agents. | Florida | Florida | Jennifer McCafferty-Cepero, PhD | Blood/Bone Marrow/Lymph | gluthionine, myeloma | Cranberries | ||
| A Pilot Study of Silymarin During Maintenance Therapy in Children with Acute Lymphoblastic Leukemia (ALL) and Abnormal Liver Function Tests (2001) | Dr. Kelly did a controlled trial with silymarin, the active ingredient of milk thistle, to determine whether it decreases liver toxicity in children receiving chemotherapy for acute lymphoblastic leukemia. | New York | New York | Kara Kelly, MD | Blood/Bone Marrow/Lymph | silymarin, milk thistle, acute lymphoblastic leukemia | |||
| A Novel Strategy Using Dietary Sphingolipids for the Prevention and Treatment of Ovarian Cancer (2004) | This study investigated whether feeding sphingomyelin, a naturally occurring lipid, to mice implanted with ovarian cancer cells infuences the growth of the cells. | Virginia | Virginia | Eva M Schmelz, PhD | Ovary | sphingomyelin, lipids | |||
| A Novel Retinoid-Responsive Growth Suppressor Gene in Breast Cancer (1998) | Dr. Eckert examined the role of TIG3, a recently identified tumor suppressor gene, in inhibition of breast cancer growth by retinoids and the factors that mediate expression of this gene. | Ohio | Ohio | Richard L Eckert, PhD | Breast | TIG3, retinoids | |||
| A Mouse Model to Understand Connections Between Dietary Folate Deficiency and Leukemogenesis (2005) | This study investigated several animal models to determine whether there is a connection between folate defciency and development of leukemia. | Colorado | Colorado | James DeGregori, PhD | Blood/Bone Marrow/Lymph | leukemia, folate deficiency | Legumes (Dry Beans, Peas & Lentils) | ||
| A Culturally Specific Dietary Plan to Manage Weight Gain Among African American Breast Cancer Survivors (2006) | This was a two-year study designed to assess the feasibility of adopting and maintaining a low fat dietary plan in low-income African-American women who are breast cancer survivors. The study was multi-institutional and recruited subjects from four hospitals. The investigators assessed numerous surveys and behavioural scales in addition to biomarkers and dietary intake throughout the study. | Maryland | Maryland | Renee Royak-Schaler, PhD | Breast | low-fat diet, African Americans, cancer survivorship, biomarkers | |||
| A Comparative Study of Adenoma in Brazil, Japan and Hawaii (2006) | This study examined diet and colorectal adenoma incidence in groups of Japanese living in Brazil, Hawaii and Tokyo. | Hawaii | Hawaii | Loic Le Marchand, MD, PhD | Colon/Rectum | adenoma, diet, genetic susceptibility, Japanese migrants, Brazil | |||
| A Clinical Trial of Vitamin D Treatment of Prostate Cancer (1997) | Dr. Feldman performed a clinical trial of 1,25-dihydroxy vitamin D (calcitriol) in treatment of prostatic cancer. | California | California | David Feldman, MD | Prostate | calcitriol, clinical trial | |||
| A Case-Control Study of Risk Factors for Gastric Cancer in Three Geographic Areas of Mexico (1996) | Dr. Lopez-Carillo completed her hospital case control study of a possible relationship between high consumption of hot chili peppers and gastric cancer by analyzing the serum specimens obtained during the previous grant period for H. pylori and analyzing the collected data. | Mexico | Mexico | Lizbeth Lopez-Carrillo, DrPH | Stomach | chili peppers, capsaicin, Helicobacter pylori, gastric infection, Mexico | |||
| A Case-Control Study of Risk Factors for Gastric Cancer in Three Geographic Areas of Mexico (1993) | People in Mexico who eat hot chili peppers have five times higher rates of gastric cancer than non-chili eating people. Capsaicin, the ingredient that makes peppers taste hot, is thought to be the culprit. Moreover, the gastric infection, by Helicobacter pylori, is also thought to play a role in gastric cancer. Dr. Lopez-Carrillo studied this issue using a food questionnaire and blood samples from volunteers in various regions of Mexico. Resolution of this question could result in possibly recommending eliminating hot chili peppers from the Mexican diet and potentially decreasing gastric cancer incidence by nearly 70%. | Mexico | Mexico | Lizbeth Lopez-Carrillo, DrPH | Stomach | chili peppers, capsaicin, Helicobacter pylori, gastric infection, Mexico | |||
| A Case-Control Study of Diet and Acetyltransferase in Non-Hodgkins Lymphoma (1999) | Dr. Chiu investigated meat preparation and level of consumption in relation to the status of certain enzymes and incidence of non-Hodgkin lymphoma in people from eastern Nebraska. | Nebraska | Nebraska | Brian C Chiu, PhD | Blood/Bone Marrow/Lymph | meat preparation, non-Hodgkin lymphoma | |||
| Diet and Exercise Targeting Weight Loss in Public Hospital Breast Cancer Patients (2002) | Dr. Chlebowski�s sought to determine whether a low-fat diet combined with an exercise program can reduce weight and increase insulin sensitivity in post-menopausal breast cancer patients, thus reducing the likelihood of cancer recurrence. | California | California | Rowan T Chlebowski, MD, PhD | Breast | physical activity, low-fat diet, insulin |




