Effect of Caloric Restriction on DNA Binding and DNA Adduct Removal In Vivo (1992)

Title:

Effect of Caloric Restriction on DNA Binding and DNA Adduct Removal In Vivo

Key words:

caloric restriction, polycyclic aromatic hydrocarbons, adducts

Research Institution:

Memphis State University

Location:

Tennessee

Researcher:

King-Thom Chung

Project Description:

Dr. Chung investigated whether the reduction in genotoxicity of polycyclic aromatic hydrocarbons by caloric restriction might be due to a decrease in DNA adduct formation or an increase in adduct removal from the liver of carcinogen-treated mice. This was a collaborative study supported by AICR and the Food and Drug Administration�s National Center for Toxicological Research.