Promotion of Apoptosis by Vitamin D3 and the Vitamin D3 Analog EB 1089 in Irradiated Breast Tumor Cells (1999)

Title:

Promotion of Apoptosis by Vitamin D3 and the Vitamin D3 Analog EB 1089 in Irradiated Breast Tumor Cells

Key words:

vitamin D3, apoptosis, radiation treatment

Research Institution:

Virginia Commonwealth University

Location:

Virginia

Researcher:

David A Gewirtz

Project Description:

Dr. Gewirtz investigated how vitamin D, or analogs which are less hypercalcemic, can induce apoptosis in breast cancer cells, what cell signaling or regulatory factors are involved, and whether vitamin D compounds can sensitize radioresistant breast cancer cells to radiation treatment.