Differential Gene Regulation in Normal and Transformed Keratinocytes by 1,25 (OH) 2D3 and Retinoic Acid (1998)

Title:

Differential Gene Regulation in Normal and Transformed Keratinocytes by 1,25 (OH) 2D3 and Retinoic Acid

Key words:

retinoic acid, vitamin D3, squamous cell carcinoma, keratinocytes

Research Institution:

University of California, San Francisco

Location:

California

Researcher:

Daniel D Bikle

Project Description:

Dr. Bikle investigated the mechanism underlying the differential responses of normal human keratinocytes and squamous carcinoma cells to treatment with vitamin D3 and retinoic acid, based on the concept that transcriptional intermediary factors are involved in the different responses.