Abnormal Receptor for a Vitamin A Derivative in Promyelocytic Leukemia (1996)

Title:

Abnormal Receptor for a Vitamin A Derivative in Promyelocytic Leukemia

Key words:

NPM-RAR, vitamin A, retinoic acid, actue promyelocytic leukemia

Research Institution:

University of Pittsburgh

Location:

Pennsylvania

Researcher:

Robert L Redner

Project Description:

Based on preliminary results that showed that the specific fusion protein (NPM-RAR) inhibits differentiation of myeloid cells, Dr. Redner continued his investigations into the mechanism whereby NPM-RAR might alter vitamin A signaling and may compete with retinoic acid receptors for binding to a family of proteins which are essential to retinoic acid receptor function.