Identification of Citric Acid Induced Apoptosis Genes (1996)

Title:

Identification of Citric Acid Induced Apoptosis Genes

Key words:

citrus fruits, citrate

Research Institution:

University of Colorado Health Sciences Center

Location:

Colorado

Researcher:

Bertrand C Liang

Project Description:

Based on preliminary data, Dr. Liang observed that citrate, a major constituent of citrus fruits, induces apoptosis in glioma cells. He studied the mechanism of citrate dependent apoptosis in glioma cells by identifying and cloning genes whose transcription is induced or repressed in response to citrate.