Activation of a Tumor Suppressor Gene by Nutrient Derivatives (1996)

Title:

Activation of a Tumor Suppressor Gene by Nutrient Derivatives

Key words:

butyrate, p21(WAF1) tumor supprossor gene, high-fiber diet, low-fiber diet

Research Institution:

University of Pittsburgh

Location:

Pennsylvania

Researcher:

Richard Steinman

Project Description:

Dr. Steinman investigated whether the protective action of butyrate, found in dietary fiber, against colon cancer involves activation of a tumor suppressor gene named p21(WAF1) by following the presence of this gene in colon biopsy samples from patients on high or low fiber diets.