Role of Retinoid Receptors in Mediating the Response to 1,25 (OH)2D3 of Normal and Transformed Keratinocytes (1996)

Title:

Role of Retinoid Receptors in Mediating the Response to 1,25 (OH)2D3 of Normal and Transformed Keratinocytes

Key words:

retinoic acid, vitamin D, keratinocytes

Research Institution:

University of California, San Francisco

Location:

California

Researcher:

Daniel D Bikle

Project Description:

Dr. Bikle tested whether retinoic acid (RA), selective RA receptor agonists and retinoid X receptor agonists alter proliferation and differentiation, as regulated by 1,25-dihydroxyvitamin D in normal and transformed keratinocytes from epidermis, and the interactions of these components in regulating gene expression.