Breast Cancer Cell Cycle Protein Regulation by a Metabolite of Vitamin A (1996)

Title:

Breast Cancer Cell Cycle Protein Regulation by a Metabolite of Vitamin A

Key words:

estrogen, Bcl-2 gene, progestins, growth factor

Research Institution:

University of Ottawa

Location:

Canada

Researcher:

M.A. Christine Pratt

Project Description:

The role of estrogen and of the estrogen receptor on regulation of the Bcl-2 gene, implicated as necessary for survival of the MCF-7 line of breast cancer cells, was investigated by Dr. Pratt. Further, the function of progestins and various growth factors in regulating Bcl-2 and other members of this gene family were examined.