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Cell Proliferation and Esophageal Carcinogenesis in Zinc Deficient Rats (1995)

Title:

Cell Proliferation and Esophageal Carcinogenesis in Zinc Deficient Rats

Key words:

zinc deficiency

Research Institution:

Thomas Jefferson University

Location:

Pennsylvania

Researcher:

Louise Y Fong

Project Description:

During the previous funding period, Dr. Fong obtained data to demonstrate that esophageal tumor incidence was 100% in the zinc deficient versus 23% and 7% in the zinc sufficient and ad libitum pair fed rats. She found that prolonged cell proliferation induced by zinc deficiency can lead to esophageal tumorigenesis. Dr. Fong continued her biochemical analysis of tissues collected to further clarify the relationship of zinc to carcinogenesis.

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