Interactions of Retinoic Acid and Transforming Growth Factor Beta in Chemoprevention of Human Papillomavirus-induced Cancer (1995)

Title:

Interactions of Retinoic Acid and Transforming Growth Factor Beta in Chemoprevention of Human Papillomavirus-induced Cancer

Key words:

retinoids, HPV, growth factor beta

Research Institution:

University of South Carolina

Location:

South Carolina

Researcher:

Kim E Creek

Project Description:

Dr. Creek examined the mechanism underlying the effects of retinoids in chemoprevention of human papillomavirus(HPV)-induced cancer. He tested the hypothesis that the retinoid induced growth inhibition of HPV is mediated by the Growth Factor Beta. These studies should help to clarify the mechanism by which the DNA of cancer-causing HPV types insert themselves into the genome of the host cell, an important first step in the development of cervical cancer.