Caloric Restriction, Aberrant Crypt Foci and Development of Colon Cancer (1995)

Title:

Caloric Restriction, Aberrant Crypt Foci and Development of Colon Cancer

Key words:

high-fat diet, low-fat diet, aberrant crypt foci, caloric restriction

Research Institution:

University of Manitoba

Location:

Canada

Researcher:

Ranjana P Bird

Project Description:

Dr. Bird investigated whether high or low fat diets and caloric restriction alter the response, in an animal model, to determine whether aberrant crypt foci (ACF) can predict carcinogenicity. Using the ACF system, Dr. Bird sought to determine if colon cancer development can be prevented in high risk individuals by dietary means.