Dietary Lipids and Proliferative Signaling Through p21 ras Proteins (1994)

Title:

Dietary Lipids and Proliferative Signaling Through p21 ras Proteins

Key words:

p21 ras (c-ras) proteins, omega-3 and omega-6 polyunsaturated fatty acids

Research Institution:

Cleveland Clinic Foundation

Location:

Ohio

Researcher:

Mladen Golubic

Project Description:

Dr. Golubic has demonstrated that some nutritionally relevant fatty acids might activate the cellular p21 ras (c-ras) proteins and promote cancer development. In this study he investigated the possibility that the tumor-enhancing effects of omega-6 polyunsaturated fatty acids and the tumor inhibitory effects of omega-3 polyunsaturated fatty acids may be a consequence of the differential regulation of two important proteins (GAP and neurofibromin) which regulate c-ras.