Abnormal Receptor for a Vitamin A Derivative in Promyelocytic Leukemia (1994)

Title:

Abnormal Receptor for a Vitamin A Derivative in Promyelocytic Leukemia

Key words:

acute promyelocytic leukemia, retinoic acid, vitamin A, abnormal fusion protein

Research Institution:

University of Pittsburgh

Location:

Pennsylvania

Researcher:

Robert Redner

Project Description:

Based on the observation that Acute Promyelocytic Leukemia (APL) can be reversed by treatment with retinoic acid, a natural derivative of vitamin A, Dr. Redner investigated the molecular mechanism underlying the success of this therapy in APL. He sought to determine whether a specific abnormal fusion protein (NPM-RAR) interferes with the function of the normal retinoic acid receptor protein.