Project Description:

The hypothesis that was investigated was that aberrations in lipid metabolism may constitute a substantial portion of the energy drain associated with cancer cachexia. Dr. Chance studied the effect of supplementation of dietary carnitine and nicotinic acid on tumor bearing animals and the reduction of cachexia by stimulating mitochondrial oxidation of lipids. A combination of these two nutrients with clenbuterol, a drug, could potentially further reduce muscle wasting and cachexia.

Cancer Site(s)

• Other

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